Explosible nanocapsules excited by pulsed microwaves for efficient thermoacoustic-chemo combination therapy

Wang, Zhixiong; Zhang, Yaming; Cao, Bing; Ji, Zhong; Luo, Wanling; Zhai, Shaodong; Zhang, Dandan; Wang, Weiping; Xing, Da; Hu, Xianglong

doi:10.1039/c8nr08498j

Cited by 27 publications

(13 citation statements)

References 47 publications

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“…It was reported that after pulsed microwave irradiation, the nanocapsules absorbed energy to generate a large thermoacoustic shockwave that simultaneously decomposed molecules into carbon dioxide and ammonia, causing cavitation and, consequently, cellular damage. The thermoacoustic shockwave and the gas burst also mechanically disrupted intracellular organelles, which resulted in a high ratio of necrotic cells, and DOX was released from the cytosol into the nucleus to initiate cell death [308].…”

Section: Iontophoresismentioning

confidence: 99%

Nanotechnology approaches in the current therapy of skin cancer

Borgheti-Cardoso

Viegas

Silvestrini

et al. 2020

Advanced Drug Delivery Reviews

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Skin cancer is a high burden disease with a high impact on global health. Conventional therapies have several drawbacks; thus, the development of effective therapies is required. In this context, nanotechnology approaches are an attractive strategy for cancer therapy because they enable the efficient delivery of drugs and other bioactive molecules to target tissues with low toxic effects. In this review, nanotechnological tools for skin cancer will be summarized and discussed. First, pathology and conventional therapies will be presented, followed by the challenges of skin cancer therapy. Then, the main features of developing efficient nanosystems will be discussed, and next, the most commonly used nanoparticles (NPs) described in the literature for skin cancer therapy will be presented. Subsequently, the use of NPs to deliver chemotherapeutics, immune and vaccine molecules and nucleic acids will be reviewed and discussed as will the combination of physical methods and NPs. Finally, multifunctional delivery systems to codeliver anticancer therapeutic agents containing or not surface functionalization will be summarized.

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Section: Iontophoresismentioning

confidence: 99%

Nanotechnology approaches in the current therapy of skin cancer

Borgheti-Cardoso

Viegas

Silvestrini

et al. 2020

Advanced Drug Delivery Reviews

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“…This confined heat results in thermoelastic expansion and then produces shockwaves via thermal acoustic cavitation. [ 30–33,48,49 ]…”

Section: Introductionmentioning

confidence: 99%

Pulsed Microwave‐Induced Thermoacoustic Shockwave for Precise Glioblastoma Therapy with the Skin and Skull Intact

Zhang

Xing

et al. 2022

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chemotherapy. [2][3][4] Glioblastoma usually invades the brain tissue in a radiative way and has no definite boundary; thus, complete neurosurgical resection is rarely achieved. [2,[4][5][6] Postoperative adjuvant conventional radiotherapy and chemotherapy are limited by intratumoral hypoxia, inadequate ability of drugs to cross the bloodbrain barrier (BBB), drug resistance, and serious side effects. [7][8][9] The median survival remains <15 months, [7][8][9][10][11] and new therapeutic strategies are desperately needed.Phototherapies with localized treatment and reduced side effects are alternative promising modalities for glioblastoma treatment. Phototherapy involves laser absorption by a photosensitizer to generate photochemical reaction as in photodynamic therapy (PDT) [11][12][13][14][15] or to generate localized hyperthermia as in photothermal therapy (PTT). [16][17][18][19] Unfortunately, oxygendependent PDT does not have good therapeutic efficacy on hypoxic tumors. [11,18] PTT can cause thermal diffusion and can damage surrounding normal cells, [19] thus yielding impaired brain function. High-efficiency and precise glioblastoma treatment methods are still urgently needed.We recently demonstrated that pulsed laser induced ultrasonic shockwaves (photoacoustic therapy, PA therapy) can selectively destroy glioblastoma tumors with no observable side effects on normal tissue. [16,[20][21][22] In PA therapy, nano particles in targeted tumor cells can absorb energy of pulsed laser and transferred into ultrasonic shockwaves via photoacoustic cavitation. [23,24] The shockwave intensity decays rapidly from the target tissue (approximately tens of micrometers), [25] and thus PA shockwave can cause minimal damage to normal cells around tumor and realize local mechanical damage to tumor cells. PA therapy overcomes the shortcomings of PTT: There is reduced thermal damage to surrounding tissue. PA therapy is also not limited by hypoxia in the tumor microenvironment like PDT. PA therapy presents unique advantages in the precise and efficient treatment of glioblastoma. However, PA therapy is usually limited by light penetration depth due to the strong optical scattering of biological tissues, thus making it difficult to achieve effective treatment of glioblastoma with intact skin and skull. [17,26,27] Microwave scattering in soft tissue is three orders of magnitude weaker than optical scattering because microwaves have Glioblastoma has a dismal prognosis and is a critical and urgent health issue that requires aggressive research and determined clinical efforts. Due to its diffuse and infiltrative growth in the brain parenchyma, complete neurosurgical resection is rarely possible. Here, pulsed microwave-induced thermoacoustic (MTA) therapy is proposed as a potential alternative modality to precisely and effectively eradicate in vivo orthotopic glioblastoma. A nanoparticle composed of polar amino acids and adenosine-based agonists is constructed with high microwave absorbance and selective penetration of the blood-brain barr...

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“…More than 300 natural amino acids have been found, but only 20 amino acids take part in the human protein synthesis ( Canfield and Bradshaw, 2019 ; Kelly and Pearce, 2020 ). Most of the 20 amino acids are good raw materials for fabricating micelles, for example, lysine ( Itaka et al, 2003 ; Cheng et al, 2021 ; Kanto et al, 2021 ), arginine ( Yao et al, 2016 ; Jiao et al, 2019 ), histidine ( Guan et al, 2019 ; Wang Z. et al, 2019 ), glutamic acid ( Krivitsky et al, 2018 ; Ma et al, 2020 ; Brunato et al, 2021 ), aspartic acid ( Yeh et al, 2013 ; Teng et al, 2017 ), cysteine ( Xu W. et al, 2015 ). Among them, there are three basic amino acids namely, lysine, histidine, and arginine, whose side chains contain amino, imidazolyl, and guanidine groups, respectively.…”

Section: Introductionmentioning

confidence: 99%

Micelles Based on Lysine, Histidine, or Arginine: Designing Structures for Enhanced Drug Delivery

Liu

Chen

et al. 2021

Front. Bioeng. Biotechnol.

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Natural amino acids and their derivatives are excellent building blocks of polymers for various biomedical applications owing to the non-toxicity, biocompatibility, and ease of multifunctionalization. In the present review, we summarized the common approaches to designing and constructing functional polymeric micelles based on basic amino acids including lysine, histidine, and arginine and highlighted their applications as drug carriers for cancer therapy. Different polypeptide architectures including linear polypeptides and dendrimers were developed for efficient drug loading and delivery. Besides, polylysine- and polyhistidine-based micelles could enable pH-responsive drug release, and polyarginine can realize enhanced membrane penetration and gas therapy by generating metabolites of nitric oxide (NO). It is worth mentioning that according to the structural or functional characteristics of basic amino acids and their derivatives, key points for designing functional micelles with excellent drug delivery efficiency are importantly elaborated in order to pave the way for exploring micelles based on basic amino acids.

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Explosible nanocapsules excited by pulsed microwaves for efficient thermoacoustic-chemo combination therapy

Abstract: Microwave irradiation is a powerful non-invasive approach for treating deep-seated diseases in a clinical setting.

Cited by 27 publications

References 47 publications

Nanotechnology approaches in the current therapy of skin cancer

Nanotechnology approaches in the current therapy of skin cancer

Pulsed Microwave‐Induced Thermoacoustic Shockwave for Precise Glioblastoma Therapy with the Skin and Skull Intact

Micelles Based on Lysine, Histidine, or Arginine: Designing Structures for Enhanced Drug Delivery

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