Response rate of bone mineral density to teriparatide in postmenopausal women with osteoporosis

Gallagher, J. Christopher; Rosen, Clifford J.; Chen, P.; Misurski, Derek; Marcus, Robert

doi:10.1016/j.bone.2006.06.007

Cited by 48 publications

(33 citation statements)

References 31 publications

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“…Paired t-tests were performed to determine the changes in measured variables over the 12-month study period. The least significant change (LSC) for measured BMD variables was also calculated (20) resulting in an LSC of 3% at the measured sites. Pearson correlation coefficients were computed to explore the relationship between changes in bone mineral values during a 12-month study period with baseline body composition and blood biochemical variables.…”

Section: Discussionmentioning

confidence: 99%

Adipocytokine and ghrelin levels in relation to bone mineral density in physically active older women: longitudinal associations

Jürimäe¹,

Kums

Jürimäe³

2009

European Journal of Endocrinology

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Purpose: We investigated the relationship between the decrease in bone mineral mass (BMC) and bone mineral density (BMD) values with baseline adipocytokine and ghrelin concentrations in physically active postmenopausal women. Methods: Leptin, adiponectin, ghrelin, BMC, BMD and different body composition values were measured in 35 women (age: 69.7G6.0 years) before and after a 12-month prospective study period. Results: Significant (P!0.05) decreases in fat-free mass (FFM) (by 2.56%) and BMC (by 1.63%) and increases in adiponectin (by 14.8%) were seen in older females as a result of the study period. The independent variables that were associated with decreases in total BMC were baseline fat mass (FM) and adiponectin explaining 30.6% (R 2 !100) of the total variance. In another model, baseline FFM and leptin were the independent variables that explained 20.6% (P!0.05) of the total variance in the decreases in total BMD value. The variables that were associated with decreases in femoral neck BMD were FM and leptin (R 2 Z0.102; P!0.05), while the independent variables were baseline trunk fat:leg fat ratio and adiponectin in the model with decreases in lumbar spine BMD as the dependent variable, and accounted for 13.1% (P!0.05) of the decreases in BMD variance. Conclusions: Initial adiponectin concentration together with specific body composition characteristics predicted loss in BMC and lumbar spine BMD values, while initial leptin concentration together with specific body composition parameters determined the loss in total and femoral neck BMD values in physically active older women.

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Section: Discussionmentioning

confidence: 99%

Adipocytokine and ghrelin levels in relation to bone mineral density in physically active older women: longitudinal associations

Jürimäe¹,

Kums

Jürimäe³

2009

European Journal of Endocrinology

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“…Увеличение МПК за 3 года перорального приема БФ достигает 8% в позвоночнике и 3,5% в бедре, при этом отмечается снижение риска пере-ломов различной локализации до 50%. Однако у части па-циентов это лечение не дает положительного эффекта, и только у 70-75% больных в клинических исследованиях было отмечено повышение МПК при назначении БФ [1][2][3]. Существование резистентных к БФ пациентов пред-ставляет потенциальную проблему для клиницистов [4].…”

Section: Discussionunclassified

Farnesyl Diphosphate Synthase (Fdrs) and Geranylgeranyl Diphosphate Synthase (Ggsp1) Gene Polymorphisms and Efficiency of Therapy With Bisphosphonates in Russian Women With Postmenopausal Osteoporosis: A Pilot Study

Крылов¹,

Никитинская²,

Samarkina³

et al. 2016

rsp

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“…Bone turnover assessment although some evidence suggests that this limit should be at least 20% (39,40). Thus, the need of specific reference intervals in different ages and establishment of LSC could be obstacles in the use of BTM in clinical practice.…”

Section: Recommendations In Btm Analysis and Interpretationmentioning

confidence: 99%

Bone turnover assessment: a good surrogate marker?

Dreyer

Vieira

2010

Arq Bras Endocrinol Metab

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SummaryTo asses fracture risk, bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is the most commonly used tool. The search for clinical risk factors is also advised and can provide a 10-year fracture probability (FRAX model). Another important determinant of bone strength is bone remodeling. High bone remodeling rates have been associated with a higher fracture risk and bone turnover markers (BTM) may offer dynamic information about skeletal status independent of BMD. The efficacy of antiresorptive agents in fracture prevention goes beyond what can be predicted by BMD especially in the beginning of the treatment. Inhibition of bone remodeling itself is certainly an important mechanism by which antiresorptive agents can rapidly reduce fracture risk. Thus, it seems quite logical to use BTM in patients with bone disease. It can also become a valuable surrogate marker in fracture prediction. However, BTM's pre-analytical and analytical variability should always be considered. Arq Bras Endocrinol Metab. 2010;54(2):99-105 Keywords Bone turnover; biochemical markers; osteoporosis; fracture SumárioO método mais utilizado para avaliação do risco de fraturas é a densitometria óssea pela téc-nica de DXA (absorciometria por raios-X duo-energética). A pesquisa de condições clínicas de risco também é recomendada e fornece uma estimativa da probabilidade de fratura em 10 anos (modelo FRAX). Outro fator importante é o grau de remodelação óssea. Um aumento da taxa de remodelação tem sido associado a um maior risco de fraturas e aumento dos marcadores ósseos. A medida desses marcadores fornece informação adicional independente da densitometria. A eficiência das medicações antirreabsortivas na prevenção de fraturas não é explicada apenas pelo aumento da densidade óssea. A menor remodelação óssea é um mecanismo que pode explicar a redução da taxa de fraturas principalmente no início do tratamento. A utilização desses marcadores nas doenças ósseas e na predição de fraturas torna-se lógica. No entanto, para interpretá-los corretamente sua variação pré-analítica e analítica deve ser considerada. Arq Bras Endocrinol Metab. 2010;54(2):99-105 Descritores Remodelação óssea; marcadores ósseos; osteoporose; fratura

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Response rate of bone mineral density to teriparatide in postmenopausal women with osteoporosis

Cited by 48 publications

References 31 publications

Adipocytokine and ghrelin levels in relation to bone mineral density in physically active older women: longitudinal associations

Adipocytokine and ghrelin levels in relation to bone mineral density in physically active older women: longitudinal associations

Farnesyl Diphosphate Synthase (Fdrs) and Geranylgeranyl Diphosphate Synthase (Ggsp1) Gene Polymorphisms and Efficiency of Therapy With Bisphosphonates in Russian Women With Postmenopausal Osteoporosis: A Pilot Study

Bone turnover assessment: a good surrogate marker?

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