Response of Patients With Duodenal Ulcer to Augmented Histamine Test as Related to Blood Groups and to Secretor Status

Ventzke, Lutz E.; Grossman, Morton I.; Ward, S

doi:10.1016/s0016-5085(62)80028-6

Cited by 21 publications

(4 citation statements)

References 9 publications

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“…The finding of no significant difference in maximal histamine-stimulated acid output in duodenal ulcer subjects between the ABO blood group and salivary ABH secretor phenotypes (Brown et al, 1956;Ventzke and Grossman, 1962) is not felt to be incompatible with the present results. The large secretory-cell mass of duodenal ulcer is almost certainly the result of multiple factors, and blood-group effect is likely to be inconspicuous, it merely allowing more group 0 than group A subjects to enter the duodenal-ulcer range.…”

Section: Discussioncontrasting

confidence: 50%

Hereditary Aspects of Duodenal Ulceration: Serum-pepsinogen Level in Relation to ABO Blood Groups and Salivary ABH Secretor Status

Hanley¹

1964

BMJ

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The association of duodenal ulcer with blood group 0 (Aird et al., 1954;Roberts, 1957) and with salivary ABH nonsecretion (Clarke et al., 1956;Doll et al., 1961) is firmly established. Thus the family studies of Doll and Kellock (1951), which showed evidence of a hereditary factor in duodenal ulcer, have been substantiated by identification of two of the responsible genetic loci-namely, those for the genes determining ABO blood group and salivary ABH secretor status. Though the underlying mechanisms whereby these genes influence liability to duodenal ulcer remain somewhat obscure, yet the present paper throws some light on one facet of the problem.Sievers (1959), using the " diagnex " blue test as a screening procedure for "achlorhydria " in several hundred patients, found evidence of free acid in 86.1% of group 0 patients but in only 73.0% of group A patients. Similarly, using the serum-pepsinogen level as an index of gastric secretion, Sievers found a significantly higher mean level in group 0 than in group A patients. These findings suggest the possibility that the possession of group 0 phenotype leads to the development of a greater gastric-acid-pepsin secretory-cell mass than that in the other ABO blood-group phenotypes. Further support for this possibility exists in the work of Purohit and Shukla (1960), who related the mean acid output in response to an alcohol test meal to the ABO blood groups, and in the clinical evidence, wherein there is not only decreasing gastric acidity but also a gradual switch from preponderance, relative to the control population, of group 0 to that of group A, in the following series of conditions-duodenal ulcer, gastric ulcer, gastric cancer, and pernicious anaemia (K0ster et al., 1955).While the present study was in progress Niederman et al. (1962), in a survey of 1,000 university intake students, stated that they found no significant differences between the mean serum-pepsinogen levels of the various ABO blood group and salivary ABH secretor phenotypic classes. Nevertheless, the mean level was higher in group 0 salivary ABH non-secretors than in group A salivary ABH secretors (P<0.2). For the following reasons it is felt that the negative results of Niederman et al. (1962) (1958) found correlation between the means of repeated basal estimates of acid and pepsin secretion and the serum-pepsinogen level. It thus seems likely that the latter affords an index of the gastric peptic-cell mass (Hirschowitz, 1955). Because under most conditions the output of acid and that of pepsin are roughly parallel (Spiro et al., 1956), it may be presumed with a fair degree of confidence that the serum-pepsinogen level reflects the size of the gastric secretory-cell mass (in this article the term " gastric secretory-cell mass " refers to the parietal and peptic cells but excludes the mucus-secreting cell mass). Material and MethodsLarge numbers of healthy individuals aged 18 to 35 inclusive from the population were screened in order that the serumpepsinogen level of the 100 subjects could b...

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Section: Discussioncontrasting

confidence: 50%

Hereditary Aspects of Duodenal Ulceration: Serum-pepsinogen Level in Relation to ABO Blood Groups and Salivary ABH Secretor Status

Hanley¹

1964

BMJ

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“…Similarly Purohit and Shukla (1960) showed that more acid was secreted in response to an alcohol test meal by young Indian medical students of blood group 0 than by those of groups A, AB, or B. Studies of duodenal ulcer patients, however, have not shown any differences in acid secretion according either to ABO blood group or secretor status (Peebles Brown et al, 1956;Ventzke and Grossman, 1962).…”

Section: Discussionmentioning

confidence: 98%

ABO blood group and secretor status in relation to clinical characteristics of peptic ulcers

Langman¹,

Doll²

1965

Gut

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EDITORIAL SYNOPSIS A large series of peptic ulcer patients divided into groups according to those who bled, those who required operation, and those who had neither bleeding nor operation showed a dissociation between ABO blood group and secretor status. Patients who had undergone operation showed a higher proportion of non-secretors for both gastric and duodenal ulcers than others. Ulcer patients who bled showed an increased frequency of blood group 0 compared with the others, but there was no difference as between the operation and non-operation groups. A careful statistical analysis of results and review of previous work on this subject makes the findings in this paper important, particularly as a possible guide to prognosis.Possible relationships between genetic factors and ulcer prognosis have received attention since the discovery by Aird, Bentall, Mehigan, and Roberts (1954) that there is an association between blood group 0 and liability to peptic ulcer.

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“…As no specific pattern in the causes of deaths, either by division according to the source of t h e haemorrhage or ABO blood group was found, the expected causes of deaths and the observed are given in Table V for the material as a whole. tion, and ABO blood group have been conflicting (6,8,20,30,33,41,44,47). A lower plasma concentration of coagulation factor VIII is found in patients with group 0 compared to group A (43), but the clinical significance of this is uncertain.…”

Section: Resultsmentioning

confidence: 99%

Long-Term Survival of Patients with Gastrointestinal Haemorrhage with Special Reference to the ABO Blood Groups

Viskum

1972

Scandinavian Journal of Gastroenterology

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Among 986 patients admitted to hospital in the period 1938 to 1967 for gastrointestinal haemorrhage, 882 were blood grouped. A significant excess of blood group 0 was found among patients with haemorrhagic gastritis and duodenal ulcer. Of 802 blood-grouped patients who left the hospital alive, 800 were retraced 2 to 31 years later. The observed deaths exceeded the expected in all groups, being most pronounced in patients previously operated on, followed by patients with gastric ulcer. duodenal ulcer, and haemorrhagic gastritis. The reason for the higher number of deaths than expected was primarily a continuing high death rate due to haemorrhage, perforation. and selective operation for ulcer. Patients with blood group 0, B or AB had a higher excess death rate than patients with blood group A. The difference however was not statistically significant. Scand J Gastroenterol Downloaded from informahealthcare.com by Nyu Medical Center on 11/02/14 For personal use only. Scand J Gastroenterol Downloaded from informahealthcare.com by Nyu Medical Center on 11/02/14 For personal use only. 4. Berg, M. 1969. lnfluence of age and ABO blood group in the precipitation of bleeding peptic ulcers. Gtrt 10, 1029-1030. 90, 65-84. Scand J Gastroenterol Downloaded from informahealthcare.com by Nyu Medical Center on 11/02/14 For personal use only. Review of medically treated bleeding gastric or duodenal ulcers. Actn chir. scand. 120, 66-78. 42, 292-294. Scand J Gastroenterol Downloaded from informahealthcare.com by Nyu Medical Center on 11/02/14For personal use only.

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Response of Patients With Duodenal Ulcer to Augmented Histamine Test as Related to Blood Groups and to Secretor Status

Cited by 21 publications

References 9 publications

Hereditary Aspects of Duodenal Ulceration: Serum-pepsinogen Level in Relation to ABO Blood Groups and Salivary ABH Secretor Status

Hereditary Aspects of Duodenal Ulceration: Serum-pepsinogen Level in Relation to ABO Blood Groups and Salivary ABH Secretor Status

ABO blood group and secretor status in relation to clinical characteristics of peptic ulcers

Long-Term Survival of Patients with Gastrointestinal Haemorrhage with Special Reference to the ABO Blood Groups

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