Response of Paget's disease to porcine and salmon calcitonins

DeRose, Joseph J.; Singer, Frederick R.; Avramides, A.; Flores, Adelina; Dziadiw, Roman; Baker, Richard K.; Wallach, Stanley

doi:10.1016/0002-9343(74)90815-8

Cited by 155 publications

(39 citation statements)

References 9 publications

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“…There are various theoretical grounds for using exogenous CT in patients with uremic osteodystrophy on dialysis: CT is effective in other high turnover osteopathies (Paget's disease) [3,9]: furthermore, in renal bone disease it may play a protective role [4,5], The results we have so far documented in uremic patients on dialysis with clinical and morphological signs of osteodystrophy, are worthy of note. In nearly all cases, clinical signs of bone disease may reduce or disappear during CT treatment, while associated biochemical changes are not so significant.…”

Section: Discussionmentioning

confidence: 98%

Effect of Calcitonin on Bone Lesions in Chronic Dialysis Patients

Feletti¹,

Bonomini²

1979

Nephron

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The effects of synthetic salmon CT, administered subcutaneously and intermittently (1 MRC U/kg/day for 15 days/month over 6 months) were investigated in 15 uremic patients on regular dialysis treatment (RDT), all presenting various degrees of osteodystrophy. Clinically, osteoarticular pain disappeared in 8 out of 10 cases; 1 patient with rib fractures had a rapid calcification of the bone fracture repair tissue. No significant changes were found in serum calcium and PTH levels. Phosphotemia showed a significant decrease within the first 20 days. The varying individual hypophosphatemic response proved to be related to the initial level of phosphatemia. The alkaline phosphatase, when increased, showed a decrease to the normal range. A significant decrease in osteoclastic hyperactivity (active resorption surface, osteoclast index) and a slight increase in osteoblastic pool (active osteoid surface) were documented. No change was noted when osteomalacia predominated. Side effects included: anorexia, nausea, vomiting, face flushing. Our data suggest that salmon CT may be usefully employed in chronic uremic patients on RDT, when secondary hyperparathyroidism predominates.

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Section: Discussionmentioning

confidence: 98%

Effect of Calcitonin on Bone Lesions in Chronic Dialysis Patients

Feletti¹,

Bonomini²

1979

Nephron

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“…In our cases we had a good improve ment in clinical and biochemical features by 150-200 MRC units (SCT) daily. As Rose et al (13) remarked, 50 MCR units three times a week may be the minimum for long-term treat ment. How long therapy with calcitonin should be continued is not known at this time.…”

Section: Discussionmentioning

confidence: 99%

Paget’s Disease with Spinal Cord Compression

et al. 1977

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Two cases with spinal cord compression due to Paget’s disease (osteodystrophia deformans) are reported, which were treated with calcitonin (Salmon Calcitonin) during 12 and 24 months after decompressive laminectomy. Both presented a favourable clinical course with improvement of sensory and bladder disturbances, paraparesis and pain. Diagnostic criteria as X-ray investigation, scintigraphy of bones, biochemical parameters and the long-term treatment with calcitonin, are discussed.

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“…Porcine and salmon calcitonins are commer cially available, and they have an established role in the treatment of Paget's disease of bone {De Rose et al, 1974), but they are potential antigens. If a patient has a history of allergy, an intradermal test using a 1:100 dilution should be carried out before the full dose is admin istered.…”

Section: Calcitoninmentioning

confidence: 99%