Response of caeruloplasmin to Escherichia coli endotoxins and adrenal hormones in the domestic fowl

Curtis, M.J.; Butler, E.J.

doi:10.1016/s0034-5288(18)32750-4

Cited by 18 publications

(8 citation statements)

References 20 publications

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“…In this study, the ceruloplasmin concentration was significantly higher in LPS-inoculated chickens in comparison with that of non-inoculated birds. The increase in the ceruloplasmin concentration in the serum of chickens after LPS injection was consistent with the findings of Butler et al, 21 Curtis and Butler, 55 and Baert et al 36 Moreover, dexamethasone, as a corticosteroid, showed greater effects on ceruloplasmin concentrations than did meloxicam. Baert et al 36 showed that different doses of sodium salicylate, as an NSAID, did not have significant effects on E. coli LPS endotoxemia in broiler chickens.…”

Section: Indicated Thatsupporting

confidence: 88%

Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by Escherichia coli Lipopolysaccharide in Broiler Chickens

Tavakoli¹,

Abdi-Hachesoo²,

Nazifi³

et al. 2020

JIR

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Purpose: Dexamethasone has been widely used to treat acute inflammatory diseases and endotoxic shocks in animal models. Meloxicam is one of the most commonly used antiinflammatory agents in avian species. However, little is known about the effects of dexamethasone and meloxicam on lipopolysaccharide (LPS)-induced acute inflammatory response in birds. In the present study, LPS-challenged broiler chickens were used to investigate the comparative protective effects of meloxicam and dexamethasone on LPSinduced acute inflammatory responses. Methods: Lipopolysaccharide (LPS)-induced acute lung injury (ALI) histopathological scores, selected serum acute phase reactants, inflammatory mediators, and gangliosides were evaluated in broiler chickens inoculated with E. coli LPS and simultaneously treated with two doses of meloxicam (0.5 and 2 mg/kg BW) and dexamethasone (2 and 4 mg/kg BW). Results: LPS-induced ALI scores were not significantly different between the meloxicamtreated, dexamethasone-treated, and untreated positive control groups at 4 hours after LPS inoculation. Interleukin-6 concentrations were also statistically the same among the positive control, dexamethasone-treated, and meloxicam-treated groups at 3 and 12 hours after LPS inoculation. However, these anti-inflammatory drugs reduced adenosine deaminase, ceruloplasmin, lipid-bound sialic acid, protein-bound sialic acid, and total sialic acid in LPS-inoculated broiler chickens at 12, 24, and 48 hours after LPS inoculation in a drug-and dose-dependent manner. Ovotransferrin concentrations were not significantly different between positive control and treatment groups at 12 hours after LPS inoculation. However, twenty-four hours after LPS inoculation, all the treated groups, except the one treated with 0.5 mg/kg meloxicam, showed significantly lower concentrations of ovotransferrin as compared with the positive control group. Conclusion: Our results showed that dexamethasone was more effective than meloxicam in inhibiting the LPS-induced response in broiler chickens by diminishing the serum levels of adenosine deaminase, ceruloplasmin, and gangliosides.

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Section: Indicated Thatsupporting

confidence: 88%

Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by Escherichia coli Lipopolysaccharide in Broiler Chickens

Tavakoli¹,

Abdi-Hachesoo²,

Nazifi³

et al. 2020

JIR

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“…Main effects for ceruloplasmin in LPS chicks was significant at P < 0.01. Hill, 1965), Escherichia coli (Curtis and Butler;1980), and coccidia (Turk, 1986). Our data clearly demonstrate that adequate levels of dietary Cu are necessary for the expression of increased plasma Cu and ceruloplasmin activity during an acute phase response.…”

Section: Discussionmentioning

confidence: 52%

Dietary Copper Level Affects Copper Metabolism During Lipopolysaccharide-Induced Immunological Stress in Chicks

1996

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Two experiments were conducted to examine the effect of dietary Cu level on Cu metabolism during the acute phase response in broiler chicks with adequate (Experiment 1) or deficient (Experiment 2) Cu. Diets based on cornstarch and isolated soybean protein were used to formulate a basal diet, and basal diet plus either 5, 10, or 15 mg/kg additional Cu as either CuO or CuSO4. Each diet was fed to six pens of five chicks per pen (Experiment 1) or eight pens of five chicks (Experiment 2). Half of the chicks on each diet were injected with Salmonella typhymurium lipopolysaccharide (LPS) on alternate days. In Experiment 1, LPS significantly decreased daily gain, feed intake, and feed efficiency (P < 0.01) and increased the concentration of Cu in blood plasma (P < 0.01). In the uninjected birds, adding 5, 10, or 15 mg/kg Cu as CuO or 15 mg/kg Cu as CuSO4 increased the rate of gain over that of chicks fed the basal diet. In the birds challenged with LPS, 10 mg/kg Cu as CuO increased the rate of gain and efficiency compared to those of chicks fed the basal diet. Addition of CuSO4 to the diet of chicks challenged with LPS did not affect gain, intake, or feed efficiency compared to those of chicks fed the basal diet. Ceruloplasmin levels were higher in chicks challenged with LPS than in control chicks (P = 0.03), and this difference tended to be greater in chickens fed CuO than in chickens fed CuSO4 (P = 0.07). In chicks challenged with LPS, feeding CuO at all levels and feeding CuSO4 to give 10 or 15 mg/kg Cu increased ceruloplasmin levels above that of chicks fed the basal diet. Hepatic Mn superoxide dismutase (SOD) and Cu/Zn SOD were not influenced by dietary Cu level or source or LPS. Results of Experiment 2 were similar to those of Experiment 1 except that supplemental CuSO4 and CuO gave similar increases in gain and CuSO4 was more effective at increasing ceruloplasmin levels. Chicks given supplemental Cu had higher ceruloplasmin levels following challenge with LPS than Cu-deficient chicks fed the basal diet. Apparently, Cu requirements are higher for chicks experiencing an acute phase response than for healthy chicks.

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“…[18] As a result, an increase in corticosterone, the main glucocorticoids, is observed later than the appearance of IL-6. [19] Cortisol can enhance expression of IL-6 receptors in liver cells and thus promotes IL-6-mediated synthesis of APPs.…”

Section: Regulation Of Acute Phase Reactions and Synthesis Of Acute Pmentioning

confidence: 99%

“…[20] The role of glucocorticoids in birds seems to be both stimulatory and regulatory. [19] The administration of glucocorticoids to domestic fowl can also stimulate APP synthesis hormone,[18] which suggest that glucocorticoids may work independently of cytokines.…”

Section: Regulation Of Acute Phase Reactions and Synthesis Of Acute Pmentioning

confidence: 99%

Acute-phase proteins: As diagnostic tool

Jain¹,

Gautam²,

Naseem³

2011

J Pharm Bioall Sci

515

412

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The varied reactions of the host to infection, inflammation, or trauma are collectively known as the acute-phase response and encompass a wide range of pathophysiological responses such as pyrexia, leukocytosis, hormone alterations, and muscle protein depletion combining to minimize tissue damage while enhancing the repair process. The mechanism for stimulation of hepatic production of acute-phase proteins is by proinflammatory cytokines. The functions of positive acute-phase proteins (APP) are regarded as important in optimization and trapping of microorganism and their products, in activating the complement system, in binding cellular remnants like nuclear fractions, in neutralizing enzymes, scavenging free hemoglobin and radicals, and in modulating the host’s immune response. APP can be used as diagnostic tool in many diseases like bovine respiratory syncytial virus, prostate cancer, bronchopneumonia, multiple myeloma, mastitis, Streptococcus suis infection, starvation, or lymphatic neoplasia. Thus, acute-phase proteins may provide an alternative means of monitoring animal health.

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Response of caeruloplasmin to Escherichia coli endotoxins and adrenal hormones in the domestic fowl

Cited by 18 publications

References 20 publications

<p>Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by <em>Escherichia coli</em> Lipopolysaccharide in Broiler Chickens</p>

<p>Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by <em>Escherichia coli</em> Lipopolysaccharide in Broiler Chickens</p>

Dietary Copper Level Affects Copper Metabolism During Lipopolysaccharide-Induced Immunological Stress in Chicks

Acute-phase proteins: As diagnostic tool

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