Thevetia peruviana, a member of the Apocynaceae family, is also known as digoxin, fortunate nut, yellow oleander, and other names. After consumption, T. peruviana plants have the potential to be fatal. In South Asian countries, especially in Sri Lanka and India, T. peruviana is frequently used for international self-harm. Around the world’s tropical and subtropical regions, T. peruviana is a common cause of toxicological emergencies. The entire plant is hazardous due to the presence of several cardiac glycosides, including neriifolin, oleandrin, thevetin A, and thevetin B. Oleander consumption causes hyperkalemia, vomiting, diarrhea, abdominal pain, and all of the above. In the majority of cases, supportive care and the administration of activated charcoal are used in the clinical therapy of either N. oleander or T. peruviana poisoning. T. peruviana-related information is compiled in this article.