Response of antioxidant enzymes and redox metabolites to cadmium-induced oxidative stress in CRL-1439 normal rat liver cells

Ikediobi, Christopher O.; Badisa, Veera L.D.; Ayuk-Takem, Lambert T.; Latinwo, Lekan M.; West, John T.

doi:10.3892/ijmm.14.1.87

Cited by 78 publications

(99 citation statements)

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“…This experimental evidence indicates the involvement of oxidative stress as well as immune system in Cadmium-mediated tissue damage. As has been previously shown, oxidative stress (enhanced ROS and LPO as well as altered anti-oxidant enzymes) is considered as one of the underlying mechanisms of toxicity [17] and antioxidants have been successful in abating some of these deleterious effects [18,19]. Our data also showed that Cadmium causes imbalance in immune regulation leading to skewing ratio towards Th1-type cytokines (high TNF-α and undetectable IL-4) compared to the controls.…”

Section: Discussionsupporting

confidence: 78%

Lithium protects against toxic effects of cadmium in the rat testes

Al-Azemi

Omu

Kehinde

et al. 2010

J Assist Reprod Genet

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Purpose To investigate the protective effect of Lithium against the toxic effect of Cadmium in the rat testes. Methods Twenty four adult male Sprague-Dawley rats were treated with four different regimens: Cadmium only, Cadmium and lithium, lithium only and controls. Rats were sacrificed after 6 weeks and testicular levels of proinflammatory cytokine (IL-4), anti-inflammatory cytokine (TNF-α), Pro-apoptotic protein (Bax) and anti-apoptotic protein (Bcl-2) were measured by ELISA while serum levels of FSH, LH, Prolactin and Testosterone were measured using the Vidas parametric system. Antioxidant status (MDA, SOD) was also assessed in serum. Histopathological changes of testes were examined using light and electron microscopy. Immunohistochemical staining for Bax, Bcl-2 and Caspase 3 were performed. Results Treatment with lithium was associated with significant reduction in the toxic effects of Cadmium as shown by reduced testicular levels of TNF-α, serum levels of Malondialdehyde and testicular level of Bax, and increased levels of IL-4, Zn-Cu SOD, Bcl-2 and Testosterone. Testicular histopathology showed that Cadmium produced an extensive germ cells apoptosis and the addition of lithium in Cadmium-treated rats significantly reduced cadmium-induced testicular damage. Conclusion(s) Lithium has a protective effect against cadmium-induced testicular apoptosis in the rat.

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Section: Discussionsupporting

confidence: 78%

Lithium protects against toxic effects of cadmium in the rat testes

Al-Azemi

Omu

Kehinde

et al. 2010

J Assist Reprod Genet

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“…Repeated inhalation of cadmium chloride (1 h per day for 3-5 weeks) also results in a progressive increase of GSH in the cell-free BAL fluid [8,[45][46][47][48][49][50]. Notably, the enzymatic activity of major antioxidants, including superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, is altered in response to cadmium exposure [51][52][53]. Thus, the ability of cadmium to elicit oxidative stress response is proven.…”

Section: Molecular and Cellular Targets Of Cadmiummentioning

confidence: 95%

Cadmium in tobacco smokers: a neglected link to lung disease?

et al. 2018

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Cadmium in tobacco smoke may contribute to the development of pulmonary emphysema. However, there is poor understanding of the mechanisms behind the pathogenic role of cadmium in this and other smoking-related lung diseases. The traditional focus on the total body burden of cadmium, estimated through analysis of urine, may not fully reflect the local burden of cadmium, since it is inhaled by smokers. Thus, assessing the local accumulation of cadmium in the lungs appears more relevant, given that there is tissue-specific retention of cadmium.In this review, we outline the principal sources of cadmium exposure and the clinical effects of occupational exposure. In addition, we review evidence on local cadmium and its association with alterations in innate immunity in tobacco smokers. Moreover, we scrutinise the data on cadmium as a cause of lung disease in translational models.We conclude that cadmium may contribute to smoking-related lung diseases, possibly via an altered redox balance and by making macrophages dysfunctional. However, there is a need for new studies on local cadmium levels and their relation to pathology in long-term tobacco smokers, as well as for more indepth studies on cellular and molecular mechanisms, to elucidate the importance of cadmium in smokingrelated lung diseases.

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“…High Cd concentrations (100-300 µM), reduce the activities of CAT, GR, SOD, GPx as well as the metabolites GSH and oxidized GSSG after 4 h exposure in rat liver cells [55].…”

Section: Sulfhydryl Group Inactivation and Oxidative Stressmentioning

confidence: 99%

Liver and Cadmium Toxicity

2013

J Drug Metab Toxicol

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Response of antioxidant enzymes and redox metabolites to cadmium-induced oxidative stress in CRL-1439 normal rat liver cells

Cited by 78 publications

References 0 publications

Lithium protects against toxic effects of cadmium in the rat testes

Lithium protects against toxic effects of cadmium in the rat testes

Cadmium in tobacco smokers: a neglected link to lung disease?

Liver and Cadmium Toxicity

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