Liver and Cadmium Toxicity

doi:10.4172/2157-7609.s5-001

Cited by 55 publications

(32 citation statements)

References 72 publications

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“…Ion exchange between Cd and essential metals in active sites of the metalloenzymes ultimately leads to their inhibition. In fact, that particular often proposed molecular mechanism of Cd hepatotoxicity was confirmed with our results7. The exposure to Cd resulted in significant increase of Cu, Fe, Zn ( p < 0.0001) and Se ( p < 0.01) in liver (Figure 3(B,C,D,F), Table 4).…”

Section: Discussionsupporting

confidence: 90%

“…The highest accumulation of Cd occurred in liver of rats co-exposed to Cd and DSF, probably as a result of DSF enterohepatic circulation and formation of Cd-DDTC, indicating that canalicular transport of Cd in hepatocytes may be linked to biliary GSH excretion7. This occurrence actually indicates an increased risk for liver health status in alcoholic-smokers undergoing DSF therapy.…”

Section: Discussionmentioning

confidence: 92%

“…Cd itself is not redox active18–20. The other pathway includes disturbance of non-enzymatic (GSH and the total sulfhydryl groups) and enzymatic antioxidants (SOD, CAT, GPx) in the liver7 , 21 , 22. Thus, prooxidative effect of Cd was confirmed with the occurrence of antioxidative enzymes inhibition, increase of LPO and detrimental effect on GSH-cycling.…”

Section: Discussionmentioning

confidence: 97%

“…Distressed cell antioxidative capacity and energy level lead to cell signaling impairment and eventually cell death by apoptosis. Also, Cd binding to cysteines –SH group of glutathione (GSH) shifts cell redox balance towards the oxidative state6 , 7.…”

Section: Introductionmentioning

confidence: 99%

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Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium

Begić

Djurić

Ninković

et al. 2017

Journal of Enzyme Inhibition and Medicinal Chemistry

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Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1 mg CdCl2/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O2 ·−) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium

Begić

Djurić

Ninković

et al. 2017

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…[1][2][3][4][5][6] It has been proposed that Cadmium mediates its cytotoxicity via several mechanisms including induction of apoptosis, ischemia, inflammation and oxidative stress. 4,5 Compelling evidence also suggests that cadmium may cause toxicity by displacing important divalent metals ions such as zinc, selenium, calcium, and copper from their binding site.…”

Section: Introductionmentioning

confidence: 99%

Spices Mixture Containing Garlic, Ginger and Nutmeg Has Protective Effects on the Kidneys and Liver of Cadmium Exposed Rats

2016

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Effects of Environmental Cadmium Exposure on the Liver in Korean Adults: Cross-Sectional and Longitudinal Studies

Seo

Eom

Lim

et al. 2023

Arch Environ Contam Toxicol

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Cadmium (Cd) is a ubiquitous environmental pollutant with an exceptionally long biological half-life. The liver is a major organ for Cd metabolism, but the toxicity of Cd is unclear. This study sought to determine whether blood Cd (BCd) level (representing recent exposure [months] to Cd) was associated with liver function in Korean adults, both cross-sectionally and longitudinally. The baseline cross-sectional study involved 2,086 adults (male: 908, female: 1,178) in 2010−2011, and 503 of them (male: 207, female: 296) were followed up in 2014−2015. BCd was measured by graphite-furnace atomic absorption spectrometry, and liver function indices (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and γglutamyltransferase [GGT]) were determined. Liver damage was de ned as an abnormal elevation of more than one liver function index. The geometric mean of BCd (1.07 µg/L) was higher in females than in males (1.16 vs. 0.96 µg/L). Liver function indices increased signi cantly in a dose-dependent manner according to the BCd levels, except for ALT in males, and were higher in males than in females. BCd level was also associated with the risk of liver damage in both sexes. No signi cant changes in BCd were observed between baseline and follow-up. The liver function indices in 2014−2015 were comparable to those in 2010−2011 in males, while ALT and GGT were signi cantly increased in 2014−2015 compared to 2010−2011 in females with relatively high BCd. These ndings suggest that even a low level of environmental Cd exposure, short-and long-term, may affect liver function, and females appear more susceptible than males.

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Liver and Cadmium Toxicity

Cited by 55 publications

References 72 publications

Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium

Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium

Spices Mixture Containing Garlic, Ginger and Nutmeg Has Protective Effects on the Kidneys and Liver of Cadmium Exposed Rats

Effects of Environmental Cadmium Exposure on the Liver in Korean Adults: Cross-Sectional and Longitudinal Studies

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