Response of antibiotic resistance to the co-existence of chloramphenicol and copper during bio-electrochemical treatment of antibiotic-containing wastewater

Ma, Xiaofang; Guo, Na; Ren, Shaojie; Wang, Shuguang; Wang, Yunkun

doi:10.1016/j.envint.2019.02.002

Cited by 71 publications

(20 citation statements)

References 38 publications

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“…The levels of Ab resistance in TEoECR isolates were likely higher due to co-selection for AbR. This may occur due to various mechanisms (e.g., co-location of resistance genes) [25]. Henriques et.…”

Section: Discussionmentioning

confidence: 99%

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Co-Selection of Heavy Metal and Antibiotic Resistance in Soil Bacteria from Agricultural Soils in New Zealand

et al. 2022

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Accumulation of trace elements (including heavy metals) in soil from usage of superphosphate fertilisers induces resistance of soil bacteria to trace elements of environmental concern (TEoEC) and may co-select for resistance to antibiotics (Ab). This study aimed to investigate selection of co-resistance of soil bacteria to Cd, Zn and Hg, and Ab in soils with varied management histories. Genetic diversity of these bacteria and horizontal transfer of Cd resistance genes (cadA and czcA) were also investigated. Soils with either pastoral and arable management histories and either high levels of Cd and Zn, or indigenous bush with background levels of these TEoEC from the Waikato region, New Zealand were sampled. Plate culturing with a range of TEoEC and Ab concentrations, Pollution Induced Community Tolerance (PICT) assay, antibiotic sensitivity, terminal restriction fragment length polymorphism (TRFLP) and horizontal gene transfer (HGT) analyses were employed to investigate co-selection of TEoEC and Ab resistance. Higher levels of bacterial resistance to TEoEC and Ab correlated with higher levels of TEoEC in soil. Bacterial community structures were altered in soils with high TEoEC levels. Cd resistance genes were transferred from donor bacterial isolates, to recipients and the transconjugants also had resistance to Zn and/or Hg and a range of Ab.

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Section: Discussionmentioning

confidence: 99%

“…Hg levels in Waikato soils are very low (>0.2 mg/Kg) and primarily from natural sources like volcanism. The high levels of Cd and Zn in Waikato soils may lead to resistance to TEoEC and subsequent co-selection for Ab resistance in these soils' bacteria [24,25].…”

Section: Introductionmentioning

confidence: 99%

Co-Selection of Heavy Metal and Antibiotic Resistance in Soil Bacteria from Agricultural Soils in New Zealand

et al. 2022

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“…Moreover, heavy metals could signi cantly in uence ARGs by shaping the bacterial communities. It is vital for bacteria to develop the resistant systems under selection pressures of heavy metal contaminations [30][31][32]. The toxic heavy metals drove the shift in the abundance and composition of some bacteria, which could conversely impact antibiotic resistance.…”

Section: Heavy Metals Induced Co-selection For Argsmentioning

confidence: 99%

“…The toxicity of heavy metals also depends largely on its concentration. Toxic heavy metals can further urge microbial communities to develop the resistance [28,[30][31][32]. However, the environmental situation in subsurface soils is relatively anoxic, which might impact heavy metal toxicity and ARG attenuation [33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Heavy Metal-Induced Co-Selection for Antibiotic Resistance in Terrestrial Subsurface Soils

Wang¹,

Lan²,

Fei³

et al. 2020

Preprint

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Background: Terrestrial surface ecosystems are important sinks for antibiotic resistance genes (ARGs) due to the continuous discharge of contaminants from human-impacted ecosystems. However, factors determining the abundance and resistance types of ARGs in terrestrial subsurface soils remain largely unknown. In this study, we investigated the abundance and diversity of ARGs, and their correlations with metal resistance genes (MRGs), mobile genetic elements (MGEs), bacteria, and heavy metals in subsurface soils in a global scale using high throughput quantitative PCR and metagenomic sequencing approaches. Results: Abundant and diverse ARGs were detected with high spatial heterogeneity among the sampling sites. Vertically, there was no significant difference in the ARG profiles between the aquifer and non-aquifer soils. Heavy metals were the key factors shaping ARG patterns in soils with high heavy metal contents, while they induced no significant effect in low contents. Moreover, heavy metals could trigger the proliferation of antibiotic resistance by increasing MGE abundance or influencing bacterial communities. Metagenomic analysis also revealed the widespread co-occurrence of ARGs and MRGs, with heavy metals possibly aggravating the co-selection of ARGs and MRGs in soils with high heavy metal contents. Conclusions: This study highlighted the heavy metal-induced co-selection for ARGs and MRGs and revealed the occurrence of ARG pollution in terrestrial subsurface soils.

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“…Recently, extensive investigations have been performed on the resistance genes' changes under the combined stresses of heavy metals and antibiotics in biofilm wastewater treatment systems (Jang et al, 2018;Ma et al, 2019). Combined feeding of CuO nanoparticles and sulfamethoxazole led to the inhibition of the nitrification process and amplification of the sulfonamide resistance gene 3 (sul3).…”

Section: Introductionmentioning

confidence: 99%

Co-selective Pressure of Cadmium and Doxycycline on the Antibiotic and Heavy Metal Resistance Genes in Ditch Wetlands

Shu

et al. 2022

Front. Microbiol.

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Abuse of heavy metals and antibiotics results in the dissemination of metal resistance genes (MRGs) and antibiotic resistance genes (ARGs). Ditch wetlands are important sinks for heavy metals and antibiotics. The relationships between bacterial communities and MRG/ARG dissemination under dual stresses of heavy metals and antibiotics remain unclear. The responses of MRGs and ARGs to the co-selective pressure of cadmium (Cd) and doxycycline (DC) in ditch wetlands were investigated after 7-day and 84-day exposures. In ecological ditches, residual rates of Cd and DC varied from 0.4 to –5.73% and 0 to –0.61%, respectively. The greatest total relative abundance of ARGs was observed in the Cd 5 mg L–1 + DC 50 mg L–1 group. A significant level of DC (50 mg L–1) significantly reduced the total relative abundances of MRGs at a concentration of 5 mg L–1 Cd stress. Redundancy analysis indicated that Cd and DC had strong positive effects on most ARGs and MRGs after a 7-day exposure. Meanwhile, the class 1 integron gene (intI1) exhibited strong positive correlations with most ARGs and cadmium resistance genes (czcA) after an 84-day exposure. Network analysis showed that Acinetobacter and Pseudomonas were the potential dominant host genera for ARGs and MRGs, and tetracycline resistance genes (tetA), czcA, and intI1 shared the same potential host bacteria Trichococcus after an 84-day exposure.

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Response of antibiotic resistance to the co-existence of chloramphenicol and copper during bio-electrochemical treatment of antibiotic-containing wastewater

Cited by 71 publications

References 38 publications

Co-Selection of Heavy Metal and Antibiotic Resistance in Soil Bacteria from Agricultural Soils in New Zealand

Co-Selection of Heavy Metal and Antibiotic Resistance in Soil Bacteria from Agricultural Soils in New Zealand

Heavy Metal-Induced Co-Selection for Antibiotic Resistance in Terrestrial Subsurface Soils

Co-selective Pressure of Cadmium and Doxycycline on the Antibiotic and Heavy Metal Resistance Genes in Ditch Wetlands

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