Respiratory Viral Infections and Coinfections in Children With Cancer, Fever and Neutropenia

Torres, Juan Pablo; Maza, Verónica De la; Kors, Lisette; Villarroel, Milena; Piemonte, Paula; Izquierdo, Giannina; Salgado, Carmen; Tordecilla, Juan; Contardo, Verónica; Farfán, Mauricio J.; Mejías, Asunción; Ramilo, Octavio; Santolaya, Marı́a Elena

doi:10.1097/inf.0000000000001209

Cited by 46 publications

(58 citation statements)

References 28 publications

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“…(a) Multiplexing and the utility of identifying mixed infections. Multiplexing of molecular assays can facilitate identification of mixed viral infections (268)(269)(270). Coinfections are defined as the detection of more than one virus in a patient specimen.…”

Section: Molecular Panel Testing For Respiratory Viruses (I) Defininmentioning

confidence: 99%

“…Thus, the impact of mixed infection on patient outcomes is still under debate. Some studies show no difference in patient outcomes when coinfections are compared to single virusinfections, even in highly immunocompromised patient populations (268). Additionally, studies in immunocompetent children with lower respiratory tract infection found that RSV coinfection with any other respiratory virus was not associated with more severe disease than RSV infection alone (274).…”

Section: Molecular Panel Testing For Respiratory Viruses (I) Defininmentioning

confidence: 99%

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Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections

et al. 2018

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SUMMARYRespiratory viral infections are associated with a wide range of acute syndromes and infectious disease processes in children and adults worldwide. Many viruses are implicated in these infections, and these viruses are spread largely via respiratory means between humans but also occasionally from animals to humans. This article is an American Society for Microbiology (ASM)-sponsored Practical Guidance for Clinical Microbiology (PGCM) document identifying best practices for diagnosis and characterization of viruses that cause acute respiratory infections and replaces the most recent prior version of the ASM-sponsored Cumitech 21 document,Laboratory Diagnosis of Viral Respiratory Disease, published in 1986. The scope of the original document was quite broad, with an emphasis on clinical diagnosis of a wide variety of infectious agents and laboratory focus on antigen detection and viral culture. The new PGCM document is designed to be used by laboratorians in a wide variety of diagnostic and public health microbiology/virology laboratory settings worldwide. The article provides guidance to a rapidly changing field of diagnostics and outlines the epidemiology and clinical impact of acute respiratory viral infections, including preferred methods of specimen collection and current methods for diagnosis and characterization of viral pathogens causing acute respiratory tract infections. Compared to the case in 1986, molecular techniques are now the preferred diagnostic approaches for the detection of acute respiratory viruses, and they allow for automation, high-throughput workflows, and near-patient testing. These changes require quality assurance programs to prevent laboratory contamination as well as strong preanalytical screening approaches to utilize laboratory resources appropriately. Appropriate guidance from laboratorians to stakeholders will allow for appropriate specimen collection, as well as correct test ordering that will quickly identify highly transmissible emerging pathogens.

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Section: Molecular Panel Testing For Respiratory Viruses (I) Defininmentioning

confidence: 99%

Section: Molecular Panel Testing For Respiratory Viruses (I) Defininmentioning

confidence: 99%

Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections

et al. 2018

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“…Entre los virus que más frecuentemente afectan niños con neutropenia febril se encuentran virus respiratorio sincicial, influenza, adenovirus, parainfluenza, y metapneumovirus humano 4 . Un estudio reciente efectuado por Torres y cols., sobre 1.044 episodios de neutropenia febril en 525 niños, encontró al menos un virus respiratorio en 46% de los pacientes mediante detección de ácidos nucleicos con reacción de polimerasa en cadena 22 . De manera similar, Söderman y cols., evaluaron 87 episodios de neutropenia febril encontrando un virus respiratorio en 45% de los pacientes; ambas experiencias encontraron incidencias similares a las de otros estudios 23 .…”

Section: Búsqueda De Foco Infecciosounclassified

“…En el estudio anteriormente mencionado por Torres y cols., a pesar de que 65% del total de niños se clasificó como de alto riesgo para infección bacteriana grave, en todos los que se detectó un virus respiratorio hubo una evolución favorable en términos de: días de hospitalización, requerimiento de ventilación mecánica, días de fiebre, días de neutropenia y necesidad de cuidado intensivo, de manera similar con aquellos en quienes no se detectó virus respiratorio 22 . Esto puede sugerir que la evaluación sistemática de virus respiratorios al ingreso podría ser una herramienta valiosa en el abordaje de estos pacientes; sin embargo, se requieren más estudios para definir si es necesario internar a pacientes con neutropenia febril en quienes se detecta un virus respiratorio.…”

Section: Detección De Virus Respiratoriosunclassified

Neutropenia febril en niños con cáncer: manejo en el servicio de emergencias

Rivera-Salgado

Valverde-Muñoz

Ávila-Agüero

2018

Rev. chil. infectol.

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“…Neutropenia-related fever has been also described in pediatric non-HIV-infected patients. 3,4 The precise identification of the pathogen is often difficult. First, a rising number of infections are polymicrobial, resulting in difficulties in choosing specific treatment which produce good outcomes and few side effects.…”

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confidence: 99%

Low-dose computed tomography in assessment of pulmonary abnormalities in children with febrile neutropenia suffering from malignant diseases

et al. 2017

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Respiratory Viral Infections and Coinfections in Children With Cancer, Fever and Neutropenia

Cited by 46 publications

References 28 publications

Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections

Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections

Neutropenia febril en niños con cáncer: manejo en el servicio de emergencias

Low-dose computed tomography in assessment of pulmonary abnormalities in children with febrile neutropenia suffering from malignant diseases

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