Neutropenia febril en niños con cáncer: manejo en el servicio de emergencias

Rivera-Salgado, Daniel; Valverde-Muñoz, Kathia; Ávila-Agüero, María Luisa

doi:10.4067/s0716-10182018000100062

Cited by 16 publications

(14 citation statements)

References 29 publications

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“…40) Meanwhile, neutrophils remove bacterial and fungal pathogens and prevent infection. 41) Fever in patients with FN may be the only indicator of severe bacterial infection. 42) The mechanisms associated with baseline platelet counts and the development of FN are unknown.…”

Section: Discussionmentioning

confidence: 99%

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Risk Factors for Febrile Neutropenia Induced by Docetaxel Chemotherapy in Patients with Non-small Cell Lung Cancer

Uchida

Yamaguchi

Hosomi

et al. 2020

Biological & Pharmaceutical Bulletin

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We retrospectively obtained data of patient background and pretreatment characteristics from medical records and identified the predictive factors of febrile neutropenia (FN) in patients with non-small cell lung cancer (NSCLC) treated with docetaxel alone or in combination with the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab. Patients were eligible for inclusion in the study if they were 20 years or older, diagnosed with NSCLC, and received docetaxel monotherapy alone or in combination with bevacizumab at the Department of Respiratory Medicine, Kobe City Medical Center General Hospital, between July 1, 2011, and March 31, 2018. Eighty-one patients with recurrent or advanced NSCLC were included. Multivariate stepwise logistic regression analysis with backward selection revealed that lower baseline Eastern Cooperative Oncology Group performance status (ECOG-PS) scores of 1 and 2 (odds ratio (OR), 5.098; 95% confidence interval (CI), 1.045-24.879, p 0.021) and baseline platelet count below 18.8 10 4 /µL (OR, 3.861; 95% CI, 1.211-12.311, p 0.022) were significant factors influencing the FN occurrence rate. Our results demonstrated that ECOG-PS 1-2 and lower baseline platelet count were significant risk factors of FN in patients with NSCLC receiving docetaxel-based chemotherapy. Moreover, the combination of anti-VEGF antibodies and docetaxel might be associated with increased FN frequency. Despite the limitations of this study including its retrospective design, single-center site, and small sample size, baseline ECOG-PS score and platelet count may be regarded as important indices to identify patients for prophylactic granulocytecolony stimulating factor (G-CSF) treatment before docetaxel-based chemotherapy.

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Section: Discussionmentioning

confidence: 99%

“…41) Fever in patients with FN may be the only indicator of severe bacterial infection. 42) The mechanisms associated with baseline platelet counts and the development of FN are unknown. FN occurrence group may have been more susceptible to infection.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Febrile Neutropenia Induced by Docetaxel Chemotherapy in Patients with Non-small Cell Lung Cancer

Uchida

Yamaguchi

Hosomi

et al. 2020

Biological & Pharmaceutical Bulletin

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“…The entity category includes patient information entity type, diagnosis and treatment expense entity type, inspection and examination entity type, special patient entity type, and doctor order entity type. The basic setting module includes basic setting window, basic setting business, performance statistics business, nursing link monitoring business, information push business, application setting business, nursing link entity, information entity, and performance statistics entity [ 20 , 21 ]. The Apriori algorithm is an information mining algorithm for association rules, mainly used in the medical field.…”

Section: Discussionmentioning

confidence: 99%

Medical Information Mining-Based Visual Artificial Intelligence Emergency Nursing Management System

Dong

Guo

Cao

2021

Journal of Healthcare Engineering

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This study aims to design a set of the visual artificial intelligence system based on medical information mining for hospital emergency care management. A visual artificial intelligence emergency first aid nursing management system is designed by analyzing the needs of the emergency first aid nursing management system. The results show that system personnel allocation, comparative management, record management, query management analysis, basic setup analysis, nursing management basis, and nonfunctional requirements all need to be optimized for the emergency first aid management system. In this study, the comparative management module, log management module, and the query management module are designed, and the emergency first aid management system of different APP terminal functions in different modules is described in detail. The nursing document query business is tested, and the corresponding time of query of nursing assessment sheet, nurse shift record, nurse record, and physical sign observation sheet is 375.50 ms, 351.48 ms, 336.36 ms, and 245.57 ms, respectively. It shows that the visual artificial intelligence emergency nursing management system based on medical information mining can provide convenience for clinical work to a large extent and has potential application value in hospital emergency nursing work.

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“…Studies have shown that grade III-IV LP can significantly increase the risk of secondary infection in patients, causing pneumonia, endocarditis and urinary system infection and even death. Therefore, patients who have developed grade III and IV LP often need to be treated in isolation with close body temperature monitoring and supplemented with antibiotics and antifungal drugs to prevent the onset of infection, which increases medication risks and places a socio-economic burden on patients [8]. Previous studies that have analysed risk factors for the development of LP after MTX treatment are scarce, and there is a lack of credible predictive models, requiring urgent in-depth exploration.…”

Section: Introductionmentioning

confidence: 99%

Nomogram predicting leukopenia in osteosarcoma after high-dose methotrexate chemotherapy

et al. 2022

Aging

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Purpose: To explore the trends of plasma drug concentration changes after high-dose methotrexate (MTX) treatment of osteosarcoma (OS), analyse the risk factors for leukopenia (LP) after MTX treatment, and establish a LP prediction nomogram. Methods: A total of 35 OS patients at Tianjin Medical University Cancer Institute and Hospital between 2017 and 2021 were collected (the construction cohort). Another 12 OS patients between 2019 and 2021 in P.A. Hertsen Moscow Oncology Research Center were involved (the external validation cohort). Peripheral venous blood MTX concentration (C MTX ) was monitored at 0h, 6h, 24h, 48h and 72h after MTX administration. The characteristics were collected: age, sex, body surface area, lesion site, pathological subtype, pathological fractures, American Joint Committee on Cancer (AJCC) clinical stage, MTX dose, tumour necrosis, Ki-67 index, erythrocyte count, haemoglobin count, white blood cell count, platelet count (PLT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, albumin concentration, creatinine, alkaline phosphatase, and lactate dehydrogenase. Logistic regression analysis was used to determine the risk factors for LP occurrence. Significant factors were used to construct the prediction nomogram. Results: A total of 128 MTX chemotherapy cycles from 35 OS patients were included. Female, Ki-67>20%, C MTX >112μmol/L at 6h, PLT, and AST were risk factors for post-chemotherapy LP occurrence. The LP prediction nomogram was created and validated. Conclusions: Female, C MTX at 6h, Ki-67 index, AST and PLT before MTX treatment were risk factors for LP in OS patients who received MTX treatment. The established nomogram can guide personalized LP prediction in OS patients receiving MTX chemotherapy.

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Neutropenia febril en niños con cáncer: manejo en el servicio de emergencias

Cited by 16 publications

References 29 publications

Risk Factors for Febrile Neutropenia Induced by Docetaxel Chemotherapy in Patients with Non-small Cell Lung Cancer

Risk Factors for Febrile Neutropenia Induced by Docetaxel Chemotherapy in Patients with Non-small Cell Lung Cancer

Medical Information Mining-Based Visual Artificial Intelligence Emergency Nursing Management System

Nomogram predicting leukopenia in osteosarcoma after high-dose methotrexate chemotherapy

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