Respiratory Syncytial Virus in Epidemic Bronchiolitis of Infants

Antibiotic treatment of epidemic bronchiolitis--a double-blind trial.

“…It has been shown in the U.S.A. (Beem, Wright, Hamre, Egerer, and Oehme, 1960;Chanock, Kim, Vargosko, Deleva, Johnson, Cumming, and Parrot, 1961;McClelland, Hilleman, Hamparian, Ketler, Reilly, Cornfeld, and Stokes, 1961) and in Great Britain (Sandiford and Spencer, 1962 ;Holzel, Parker, Patterson, White, Thompson, and Tobin, 1963) that respiratory syncytial virus is the predominant cause of bronchiolitis in infancy. Previous studies in Northern Ireland in 1962 and 1963 have also shown this association (Connolly, Forsyth, Haire, Evans, and White, 1963).…”

Serological Study of Respiratory Syncytial Virus Infections in Infancy and Childhood

“…It was thought useful to investigate how early in an infant's life an antigenic response could be obtained to virus infection. Though a number of workers Sandiford and Spencer, 1962;Moss et al, 1963) have studied children with bronchiolitis and pneumonia, there was still very little information regarding the antibody response of infants under 3 months of age. Moreover, we wished to study the effect of the presence of maternal antibody on the antigenic responses.…”

Respiratory illness and viral infection in an Edinburgh nursery

“…It was apparent, however, that infection by respiratory syncytial virus and parainfluenza 3 virus resulted in a much more severe illness, particularly among the infants, than did influenza C virus or adenovirus infection. Respiratory syncytial virus is known to be causally related to epidemic bronchio-litis in infants (Sandiford & Spencer, 1962) but in the present outbreak no cases of bronchiolitis were recognized.…”