Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity

Cytotoxic activity, X-ray crystal structures and spectroscopic characterization of cobalt(II), copper(II) and zinc(II) coordination compounds with 2-substituted benzimidazoles

“…In the zinc(II) coordination compounds 5,12,13,19,20,21,26,27,28 and 35, the tautomeric equilibrium of the ligand is absent, indicating that the imidazolic nitrogen is coordinated to the metal ion. Interestingly, the chemical shifts of the hydrogen atom signals were not significantly changed by the presence of the metal ion.…”

“…The 13 C NMR spectra presented equivalent signals for C8-C9, which are shifted to lower frequencies with respect to the free ligands. The signals for carbon C2 are shifted to higher frequencies in 2mbz, 2cmbz and 2cbz compounds (5,19,20,21,26,27,28), and to lower frequencies for the complexes with 2phbz and 2gbz (12, 13 and 35), upon coordination of the zinc(II) atom.…”

“…Furthermore, benzimidazoles have been employed as chemotherapeutic agents against parasitic diseases [15,16] and have shown antiviral [17][18][19][20][21][22] and antitumor activity [23,24]. Transition metal coordination compounds of benzimidazole derivatives have also promising therapeutic potential.…”

Crystal structure of 1-methyl-3-[((naphthalen-2-ylsulfonyl)oxy)imino]indolin-2-one, C19H14N2O4S

“…Some oxime derivatives have been also examined as useful pharmacophores in a range of therapeutic agents and considered as bioisosteres which provide a series of potent antiviral agents [9][10][11][12][13]. Recently, O-acyl and O-arylsulfonyl derivatives of isatin 3-oximes have been synthesized and their reactivity towards alcohols and amines has been reported [14][15][16].…”

Crystal and Molecular Structure of 2-(2-Fluoro-phenyl)-1H-benzoimidazole

“…Not only can they be used for producing medicines such as omeprazole and pimobendan, but also have they exhibited significant activities against some viruses including RSV 2 , herpes (HCV) 3 , HIV 4 and human cytomegalovirus (HCMV) 5 . Benzoimidazoles and their derivatives exhibit a number of important pharmacological properties, such as antihistaminic 6 , anti-ulcerative 7 , antiallergic 8 and antipyretic 9 .…”