Respiratory syncytial virus burden among adults during flu season: an underestimated pathology

Preventing respiratory syncytial virus infections in hospitalized children and adults: should we do better?

“…Indeed, nosocomial infections were proportionately more frequently diagnosed in adults than community-acquired ALRIs (p < 0.0001) and the total number of hospitalization days due to nosocomial RSV infection was higher in adults than in children (0.32% versus 0.11%, p < 0.0001). Similarly, Kestler M et al recently described that RSV acquisition was frequently nosocomial or healthcarerelated in adults during flu season [7]. Although we did not observe the high RSV-related mortality described in adults by Kestler (14.7%), we described longer length of hospital stay in case of nosocomial versus community-acquired infections in adults.…”

“…In infants, a severe course of nosocomial disease has been described, especially in subjects with comorbidities [5], even more severe than community-acquired RSV infections [6]. In adults, RSV acquisition seems to be frequently nosocomial or healthcare-related, with a higher mortality than with influenza virus infection [7]. However, to the best of our knowledge, no previous study compared the burden of community-acquired versus nosocomial RSV-associated acute lower respiratory tract infections (ALRIs) in both adult and pediatric patients concomitantly admitted at the same hospital.…”

Respiratory syncytial virus infection among adults during influenza season: A frequently overlooked diagnosis

“…2 Increasing evidence suggests that RSV is an important cause of disease in adults, which is similar to influenza in terms of hospital admissions and mortality in the chronically ill and elderly population. 5,14,15 In our study, despite having included the entire adult population, the median age is in the elderly, evidencing the actual epidemiology of RSV infection.…”

Systematic review on respiratory syncytial virus epidemiology in adults and the elderly in Latin America

“…Though overshadowed by its preeminent importance among pediatric populations for several decades since its recognition as a human pathogen (Walsh and Falsey 2012), RSV has become an increasingly documented cause of illness in adults. In fact, several studies exploring and reporting the burden and clinical impact of RSV among adult populations across various geographical regions, in both outpatient and inpatient settings, have been published in the last two decades (Falsey et al, 2005;Lee et al, 2013;Volling et al, 2014;Mullooly et al, 2007;Thompson et al, 2003), including in recent years (Colosia et al, 2017;Ambrosch et al, 2018;Belongia et al, 2018;Kestler et al, 2018;Ackerson et al, 2019). RSV infections have been shown to be more severe among immunocompromised adults, those with cardiopulmonary conditions, and the elderly (Volling et al, 2014;Colosia et al, 2017;Belongia et al, 2018;Chatzis et al, 2018).…”

“…RSV infections have been shown to be more severe among immunocompromised adults, those with cardiopulmonary conditions, and the elderly (Volling et al, 2014;Colosia et al, 2017;Belongia et al, 2018;Chatzis et al, 2018). Notably, various studies have suggested that the disease burden associated with RSV infections in the adult population is higher than that resulting from influenza virus infections, including in older adults (Kwon et al, 2017;Ambrosch et al, 2018;Kestler et al, 2018;Ackerson et al, 2019).…”