Respiratory Symptoms, Asthma, Atopy and Chlamydia pneumoniae IgG Antibodies in a General Population Sample of Young Adults

Ferrari, Marcello; Poli, Albino; Olivieri, Mario; Verlato, Giuseppe; Tardivo, Stefano; Nicolis, Morena; Campello, Cesare

doi:10.1007/s15010-002-2143-9

Cited by 16 publications

(11 citation statements)

References 18 publications

(21 reference statements)

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“…More recently Ferrari and coworkers found elevated antibody titers to C. pneumoniae more frequently in atopic subjects and postulated that atopic disease might be associated with a less efficient clearance of C. pneumoniae or with a more severe infection and consequently higher specific antibody titers (37). While no studies on the relationship between atopy and M. neumoniae serum antibody titers have been performed, we speculate that atopic subjects have higher anti- M. pneumoniae antibody titers than non-atopic subjects as in the case of C. pneumoniae .…”

Section: Discussionmentioning

confidence: 99%

Distributions of Antibody Titers to Mycoplasma pneumoniae in Korean Children in 2000-2003

Yoo

Kim

et al. 2005

J Korean Med Sci

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The aim of study was to describe Mycoplasma pneumoniae epidemics in a hospital-based population. Special attention was paid to the relationship between antibody titer to M. pneumoniae and sex, age, and atopy. During the eight 6-month periods between January 2000 and December 2003, serum samples were obtained from 1,319 Korean children who presented with respiratory symptoms, and were examined for antibodies to M. pneumoniae using the indirect particle agglutination test. Geometric mean antibody titers peaked in the second half of 2000 and then decreased gradually, a second peak occurred in the second half of 2003. Likewise, the frequency of high antibody titers (≥1:640) also peaked during these two periods. Antibody titers in children aged 0-3 yr were lower than in older children during both peak periods and for 2 yr after the first peak. Sex and atopy had no effect on antibody titers. During the years 2000-2003, geometric mean antibody titers and the frequencies of high antibody titers varied with time. These changes suggest a cyclic pattern of M. pneumoniae infection, with two epidemic peaks separated by 3 yr.

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Section: Discussionmentioning

confidence: 99%

Distributions of Antibody Titers to Mycoplasma pneumoniae in Korean Children in 2000-2003

Yoo

Kim

et al. 2005

J Korean Med Sci

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“…Analysis by atopic status revealed that C. pneumoniae infection was most strongly related to the risk of long-standing, nonatopic asthma (odds ratio, 6.0). However, a populationbased study in Italy found a significant association between C. pneumoniae seropositivity and atopy in young adults (odds ratio, 1.73; p ϭ 0.05) (60).…”

Section: Chronic Stable Asthmamentioning

confidence: 97%

“…There are limited data concerning the influence of atopic status on the effects of C. pneumoniae infection (42,60). One controlled study in Finland found that elevated IgG levels were significantly associated with asthma, particularly long-standing asthma (42).…”

Section: Chronic Stable Asthmamentioning

confidence: 99%

Chlamydophila pneumoniae and Mycoplasma pneumoniae

Johnston

Martin

2005

Am J Respir Crit Care Med

180

129

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The potential role of atypical bacterial infection in the pathogenesis of asthma is a subject of continuing debate. There is an increasing body of literature concerning the association between the atypical bacteria Chlamydophila pneumoniae and Mycoplasma pneumoniae and asthma pathogenesis; however, many studies investigating such a link have been uncontrolled and have provided conflicting evidence, in part due to the difficulty in accurately diagnosing infection with these atypical pathogens. This article reviews the evidence for an association between atypical bacterial respiratory pathogens and the pathogenesis of asthma, and discusses the biological mechanisms that could account for such a link. The possible role of antibacterial therapy in the management of asthma and the need for well-designed studies to investigate this is also discussed.

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“…Cpn primarily infects the human respiratory tract, and accounts for about 10% of the cases of community-acquired pneumonia and 5% of bronchitis, sinusitis, and pharyngitis cases [2–4]. The pathogen is widely distributed, and up to 50% of the population of the developed world is seropositive by the age of 20 [5,6]. Cpn has been implicated in chronic inflammatory diseases, including reactive arthritis [7], asthma [8–11], chronic obstructive pulmonary disease [12], and atherosclerosis [13,14].…”

Section: Introductionmentioning

confidence: 99%

Gene Expression Profiles of Chlamydophila pneumoniae during the Developmental Cycle and Iron Depletion–Mediated Persistence

et al. 2007

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The obligate intracellular, gram-negative bacterium Chlamydophila pneumoniae (Cpn) has impact as a human pathogen. Little is known about changes in the Cpn transcriptome during its biphasic developmental cycle (the acute infection) and persistence. The latter stage has been linked to chronic diseases. To analyze Cpn CWL029 gene expression, we designed a pathogen-specific oligo microarray and optimized the extraction method for pathogen RNA. Throughout the acute infection, ratio expression profiles for each gene were generated using 48 h post infection as a reference. Based on these profiles, significantly expressed genes were separated into 12 expression clusters using self-organizing map clustering and manual sorting into the “early”, “mid”, “late”, and “tardy” cluster classes. The latter two were differentiated because the “tardy” class showed steadily increasing expression at the end of the cycle. The transcriptome of the Cpn elementary body (EB) and published EB proteomics data were compared to the cluster profile of the acute infection. We found an intriguing association between “late” genes and genes coding for EB proteins, whereas “tardy” genes were mainly associated with genes coding for EB mRNA. It has been published that iron depletion leads to Cpn persistence. We compared the gene expression profiles during iron depletion–mediated persistence with the expression clusters of the acute infection. This led to the finding that establishment of iron depletion–mediated persistence is more likely a mid-cycle arrest in development rather than a completely distinct gene expression pattern. Here, we describe the Cpn transcriptome during the acute infection, differentiating “late” genes, which correlate to EB proteins, and “tardy” genes, which lead to EB mRNA. Expression profiles during iron mediated–persistence led us to propose the hypothesis that the transcriptomic “clock” is arrested during acute mid-cycle.

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Respiratory Symptoms, Asthma, Atopy and Chlamydia pneumoniae IgG Antibodies in a General Population Sample of Young Adults

Abstract: We conclude that C. pneumoniae infection is associated with cough and phlegm and may have a role in the pathogenesis of chronic respiratory diseases. Moreover, our results indicate a relationship between atopy and C. pneumoniae infection.

Cited by 16 publications

References 18 publications

Distributions of Antibody Titers to Mycoplasma pneumoniae in Korean Children in 2000-2003

Distributions of Antibody Titers to Mycoplasma pneumoniae in Korean Children in 2000-2003

Chlamydophila pneumoniae and Mycoplasma pneumoniae

Gene Expression Profiles of Chlamydophila pneumoniae during the Developmental Cycle and Iron Depletion–Mediated Persistence

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