Respiratory Outbreak of <i>Mycobacterium abscessus</i> Subspecies <i>massiliense</i> in a Lung Transplant and Cystic Fibrosis Center

Aitken, Moira L.; Limaye, Ajit P.; Pottinger, Paul S.; Whimbey, Estella; Goss, Christopher H.; Tonelli, Mark R.; Cangelosi, Gerard A.; Dirac, M Ashworth; Olivier, Kenneth N.; Brown‐Elliott, Barbara A.; McNulty, Steven G.; Wallace, Richard J.

doi:10.1164/ajrccm.185.2.231

Cited by 278 publications

(213 citation statements)

References 13 publications

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“…125,128 We emphasize that none of these observational studies were associated with person-to-person transmission, but such data provide evidence of the potential for such transmission and, thus, the importance of implementing strategies to prevent droplet transmission. Furthermore, as previously described the potential for transmission of M. abscessus by droplets or droplet nuclei has been suggested, 66,129 but to our knowledge no studies to date have demonstrated the specific route(s) of NTM transmission among people with CF.…”

Section: Iiid2 Healthcare Sources: Water Surfaces Equipment Airmentioning

confidence: 81%

“…massiliense has been suggested. 66,129 Transmission in one center was halted by simultaneous implementation of multiple IP&C strategies, including separation of people with CF infected with this pathogen, increased microbiologic surveillance, enhanced environmental cleaning, mask use by individuals with CF, and the use of negative pressure rooms among adults with CF. 129 (See Section III.A.5 for a more detailed description of NTM transmission.…”

Section: Iid Potential Role Of Droplet Nucleimentioning

confidence: 99%

“…The relative frequency of shared strains of different CF pathogens is shown in Table 6. 27,28,30,66,102,[129][130][131][132][133][134][135][136][137][138][139][140][141][142][143][144][145] III.A.1. Burkholderia spp.…”

Section: Iiia Person-to-person Transmission Among People With Cfmentioning

confidence: 99%

“…massiliense from a chronically infected adult with CF to 4 others attending the same clinic in Seattle. 129 The index case and 2 others died within several months of becoming infected. Similarly, typing of 41 strains of M. abscessus complex from 17 individuals with CF in the United Kingdom using a novel variable-number tandem repeat scheme and an automated rep-PCR system found that most were persistently infected with a single clone, but some shared strains; no differences in clinical outcomes linked to specific strains was reported.…”

Section: Iiia5 Nontuberculous Mycobacteriamentioning

confidence: 99%

See 3 more Smart Citations

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

339

378

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The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was commissioned by the CF Foundation as an update of the 2003 Infection Control Guideline for CF. During the past decade, new knowledge and new challenges provided the following rationale to develop updated IP&C strategies for this unique population:1. The need to integrate relevant recommendations from evidence-based guidelines published since 2003 into IP&C practices for CF. These included guidelines from the Centers for Disease Control and Prevention (CDC)/Healthcare Infection Control Practices Advisory Committee (HICPAC), the World Health Organization (WHO), and key professional societies, including the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). During the past decade, new evidence has led to a renewed emphasis on source containment of potential pathogens and the role played by the contaminated healthcare environment in the transmission of infectious agents. Furthermore, an increased understanding of the importance of the application of implementation science, monitoring adherence, and feedback principles has been shown to increase the effectiveness of IP&C guideline recommendations.2. Experience with emerging pathogens in the non-CF population has expanded our understanding of droplet transmission of respiratory pathogens and can inform IP&C strategies for CF. These pathogens include severe acute respiratory syndrome coronavirus and the 2009 influenza A H1N1. Lessons learned about preventing transmission of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant gram-negative pathogens in non-CF patient populations also can inform IP&C strategies for CF.

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Section: Iiid2 Healthcare Sources: Water Surfaces Equipment Airmentioning

confidence: 81%

Section: Iid Potential Role Of Droplet Nucleimentioning

confidence: 99%

Section: Iiia Person-to-person Transmission Among People With Cfmentioning

confidence: 99%

Section: Iiia5 Nontuberculous Mycobacteriamentioning

confidence: 99%

See 2 more Smart Citations

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

339

378

View full text Add to dashboard Cite

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“…Recent evidence of patient-to-patient transmission including the role of airborne transmission has heightened this concern. 36,37 From 2010 to 2012, when robust data in the CFFPR were available, the prevalence of all species of NTM and of MAC increased.…”

Section: Discussionmentioning

confidence: 99%

Changing Epidemiology of the Respiratory Bacteriology of Patients With Cystic Fibrosis

Salsgiver

Fink

Knapp

et al. 2016

Chest

Self Cite

197

162

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Airborne and Emerging Infectious Diseases

Chiang

Palmore

2021

Patty's Industrial Hygiene

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Airborne transmission of infections pathogens can occur in a wide range of occupational settings. Tuberculosis is a particular concern for personnel in health care and allied fields. The risk from exposure to infectious aerosols or droplet nuclei depends in part on characteristics of the source, the pathogen, and the aerosol droplets, as well as host susceptibility. The movement of infectious droplets is determined by their size and the flow of air. Many pathogens that are not classically airborne can be transmitted via aerosols under certain circumstances. Special consideration should be given to workers with immune impairment, who may be at higher risk of infection. Emerging pathogens that are not airborne but have had recent and significant public health consequences are also discussed.

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Respiratory Outbreak of Mycobacterium abscessus Subspecies massiliense in a Lung Transplant and Cystic Fibrosis Center

Cited by 278 publications

References 13 publications

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Changing Epidemiology of the Respiratory Bacteriology of Patients With Cystic Fibrosis

Airborne and Emerging Infectious Diseases

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