Respiratory Muscle Function and Hypoxic Ventilatory Control in Patients With Type I Diabetes

Mancini, Marco; Filippelli, Mario; Seghieri, Giuseppe; Iandelli, Iacopo; Innocenti, F.; Duranti, Roberto; Scano, Giorgio

doi:10.1378/chest.115.6.1553

Cited by 27 publications

(21 citation statements)

References 35 publications

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“…This finding suggests that the autonomic dysfunction might be part of a more general modification of autonomic reflexes, possibly involving an altered control of ventilation. Previous studies in diabetes showed abnormalities not only in the cardiac vagal regulation, but also in the control of blood pressure [36,37], microcirculation [38] and respiration [39,40]. Respiratory and cardiovascular control are tightly intertwined [41].…”

Section: Discussionmentioning

confidence: 99%

Short-term oxygen administration restores blunted baroreflex sensitivity in patients with type 1 diabetes

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Short-term oxygen administration restores blunted baroreflex sensitivity in patients with type 1 diabetes

et al. 2011

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“…In a cross-sectional analysis, the Atherosclerosis Risk in Communities (ARIC) study has reported that the values of FEV1 and FVC were significantly lower in type 2 diabetes than in healthy controls [66]. Using more sensitive functional tests to evaluate the respiratory mechanics such as the measurement of dynamic compliance, some authors have demonstrated a reduction of this parameter in type 1 diabetes patients, thus indirectly detecting the presence of a peripheral airway obstruction in these patients [67,68].…”

Section: Lung Volumesmentioning

confidence: 99%

The Diabetic Lung - A New Target Organ?

Pitocco

Fuso²,

Conte³

et al. 2012

Rev Diabet Stud

140

112

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■ AbstractSeveral abnormalities of the respiratory function have been reported in patients with type 1 and type 2 diabetes. These abnormalities concern lung volume, pulmonary diffusing capacity, control of ventilation, bronchomotor tone, and neuroadrenergic bronchial innervation. Many hypotheses have emerged, and characteristic histological changes have been described in the "diabetic lung", which could explain this abnormal respiratory function. Given the specific abnormalities in diabetic patients, the lung could thus be considered as a target organ in diabetes. Although the practical implications of these functional changes are mild, the presence of an associated acute or chronic pulmonary and/or cardiac disease could determine severe respiratory derangements in diabetic patients. Another clinical consequence of the pulmonary involvement in diabetes is the accelerated decline in respiratory function. The rate of decline in respiratory function in diabetics has been found to be two-to-three times faster than in normal non-smoking subjects, as reported in longitudinal studies. This finding, together with the presence of anatomical and biological changes similar to those described in the aging lung, indicates that the "diabetic lung" could even be considered a model of accelerated aging. This review describes and analyses the current insight into the relationship of diabetes and lung disease, and suggests intensifying research into the lung as a possible target organ in diabetes.

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“…A high incidence of sudden deaths has been observed in diabetic patients with diabetic autonomic neuropathy, especially during sleep. The mechanism of impairment of respiratory muscle function may be related to neuropathy, myopathy, or both [24]. Many studies have been performed in the past to assess respiratory disturbances during sleep in these patients [25].…”

Section: Diseases Of Roots and Peripheral Nervesmentioning

confidence: 99%

Neuromuscular disorders and sleep

Öztura

Guilleminault

2005

Curr Neurol Neurosci Rep

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Neuromuscular disorders are caused by the primary involvement of the motor unit. In these patients, sleep-disordered breathing (SDB) due to respiratory muscle weakness is often encountered during sleep. Because there is a tendency to overlook this disorder, all patients with neuromuscular disorders should be questioned about SDB. Overnight polysomnography is the best investigation for SDB and nocturnal desaturations. In the management of these patients, noninvasive intermittent positive pressure ventilation results in improvement of SDB and breathing.

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Respiratory Muscle Function and Hypoxic Ventilatory Control in Patients With Type I Diabetes

Cited by 27 publications

References 35 publications

Short-term oxygen administration restores blunted baroreflex sensitivity in patients with type 1 diabetes

Short-term oxygen administration restores blunted baroreflex sensitivity in patients with type 1 diabetes

The Diabetic Lung - A New Target Organ?

Neuromuscular disorders and sleep

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