Neuromuscular disorders and sleep

Öztura, İbrahim; Guilleminault, Christian

doi:10.1007/s11910-005-0013-4

Cited by 15 publications

(8 citation statements)

References 52 publications

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“…Amyotrophic lateral sclerosis (ALS), postpolio syndrome, myotonic dystrophy, myasthenia gravis, Duchenne muscular dystrophy (DMD), and other myopathies are among the common NMD associated with sleep-related complications, and different types of sleep disturbances may predominate in specific neuromuscular diseases. SDB is reported in 17-76% of patients with ALS, and in 31% of patients with postpolio syndrome [7 ]. A study of children with DMD [8 ] recently showed that obstructive sleep apnea (OSA) was present in 31% and hypoventilation in 32% of patients.…”

Section: Prevalence Of Sleep Disorders In Neuromuscular Diseasesmentioning

confidence: 99%

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Sleep disorders in neuromuscular diseases

Dhand¹,

Dhand

2006

Current Opinion in Pulmonary Medicine

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Section: Prevalence Of Sleep Disorders In Neuromuscular Diseasesmentioning

confidence: 99%

“…Bilateral phrenic nerve involvement due to local causes or as part of diffuse polyneuropathy (e.g. Charcot-MarieTooth disease, Guillain-Barré syndrome) is well recognized as a cause of nocturnal hypoventilation, oxygen desaturation, frequent arousals, and secondary daytime somnolence [7 ].…”

Section: Spinal Muscular Atrophymentioning

confidence: 99%

Sleep disorders in neuromuscular diseases

Dhand¹,

Dhand

2006

Current Opinion in Pulmonary Medicine

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“…Solunum dürtüsünde azalma uyku sırasında belirginleşir. 23 Paradoksal abdominal hareketi olan hastalarda, diyafragmanın solunuma katılımında anlamlı azalma ve dolayısıyla hem REM hem de non-REM uykusunda daha büyük oksijen desatürasyonu ortaya çıkar. Restriktif hastalıkta kan gazlarında ilk anlamlı bozukluk, REM uykusu sırasındaki hiperkapni ve hipoksidir.…”

Section: Tablo 2 Solunum Kas Zayıflığı Ile Ilişkili Problemlerunclassified

Nöromusküler Hastalıklarda Solunum Fonksiyonlarının Değerlendirilmesi: Derleme

Yeldan

Aslan²

2014

HSP

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Nöromusküler hastalıklarda kas iskelet sistemi problemlerinin yanı sıra solunum kas zayıflığı ve buna bağlı olarak solunum disfonksiyonu gelişebilmektedir. Solunumsal komplikasyonlar, özellikle kronik ve hızlı ilerleyen nöromusküler hastalıklarda, morbidite ve mortalitenin en önemli nedenlerindendir. Bu hastalarda vital kapasite azalır, restriktif solunum paterni görülür. Solunum kas zayıflığı nedeniyle, nöromusküler hastalığı olan kişilerde yorgunluk, nefes darlığı, sekresyon birikimi, tekrarlayan alt solunum yolu infeksiyonları, solunum yetmezliği, pulmoner hipertansiyon ve akut veya kronik korpulmonale gelişebilir. Uyku ile ilişkili solunumsal problemler de başlangıçta uyku sırasında görülürken hastalığın ilerlemesiyle birlikte uyanıklık dönemine de yansır. Nöromusküler hastalıklarda sistematik klinik değerlendirme, erken dönemde hastanın fiziksel kapasitesindeki yetersizlik nedeniyle maskelenen solunumsal semptom ve bulguların saptanmasında esastır. Bu derleme nöromusküler hastalıklarda karşılaşılan solunum problemleri ile anamnez, fizik muayene, solunum kas gücü ölçümleri, arter kan gazları analizi, tepe öksürük akımı ölçümü, radyolojik değerlendirme, spirometrik ölçümler ve uyku başlıkları altında değerlendirmeyi kapsamlı olarak gözden geçirecektir. Anahtar Kelimeler: Nöromusküler hastalıklar, solunum, solunumsal değerlendirme AbstractRespiratory muscle weakness and consequently respiratory dysfunction may occur as well as musculoskeletal problems in patients with neuromuscular diseases. Respiratory complications are the most important cause of morbidity and mortality particularly in chronic and rapidly progressive neuromuscular diseases. Vital capacity is reduced and a restrictive ventilatory pattern is seen in these patients. Due to respiratory muscle weakness; fatigue, breathlessness, secretion retention, recurrent lower respiratory tract infections, respiratory failure, pulmonary hypertension, and acute or chronic corpulmonale may occur in patients with neuromuscular diseases. While respiratory problems may manifest initially during sleep, it also reflect to awake period with progression of diseases. Systematic clinical evaluation of neuromuscular diseases is essential for the detection of respiratory signs and symptoms which are masked because of physical capacity inability of patients in early stage. This review will evaluate comprehensively the assessment of respiratory problems which are encountered in neuromuscular diseases under the headings of history, physical examination, respiratory muscle strength measurements, arterial blood gas analysis, peak cough flow measurements, radiologic evaluation, spirometry and sleep.

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“…Knowledge of respiratory anatomy and physiology allows an understanding of how pharyngeal muscle weakness predisposes to airway collapse and obstructive hypopnea or apnea, whereas weakness of the diaphragm produces nonobstructive hypoventilation maximal during sleep. [1][2][3]9,10 Reductions in muscle tone and chemosensitivity, especially during REM sleep, mean that any superimposed weakness of upper airway muscles, or medications that further reduce tone, reduce airway patency. Depending on severity, this could result in an increase in upper airway resistance, hypopnea, or even apnea.…”

Section: Sleep Disorders In Neuromuscular Diseasesmentioning

confidence: 99%

Sleep and Neuromuscular Disease

Nicolle

2009

Semin Neurol

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Sleep disorders in patients with neuromuscular disease are common, but underrecognized by health care providers, and sometimes by patients themselves. Their symptoms may be confused with those of the underlying disease. Their recognition is an important part of the management of patients with neuromuscular disorders, improving quality of life, and sometimes increasing survival. Inadequate ventilation underlies many sleep disorders, and sleep-related disorders may presage daytime ventilatory disorders with disease progression. Involvement of the central or peripheral nervous system, or both, may disrupt sleep, with the relative contribution of each depending on the specific disorder. The pertinent anatomy, physiology, and clinical features of sleep disorders in neuromuscular diseases and a basic approach to their assessment is discussed. Specific neuromuscular disorders in which sleep is commonly affected are reviewed and the principles of management of sleep disorders summarized.

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Neuromuscular disorders and sleep

Cited by 15 publications

References 52 publications

Sleep disorders in neuromuscular diseases

Sleep disorders in neuromuscular diseases

Nöromusküler Hastalıklarda Solunum Fonksiyonlarının Değerlendirilmesi: Derleme

Sleep and Neuromuscular Disease

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