Respiratory heat and moisture loss is associated with eosinophilic inflammation in asthma

Noble, Donald; McCafferty, J. B.; Greening, A P; Innes, J A

doi:10.1183/09031936.00071106

Cited by 15 publications

(14 citation statements)

References 28 publications

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“…EBT in our study did not correlate with spirometric indices, similarly to previous reports [9]. Children in our study reported mild exacerbations, reflected by the nearly normal spirometric indices.…”

Section: Discussionsupporting

confidence: 87%

“…Similar findings have been reported in children, where positive associations have been demonstrated between peak and plateau EBT values and NO [6]. More recently, bronchial blood flow has been significantly correlated with the rate of EBT increase and NO values in asthmatics [7], while thermal measurements have also been associated with eosinophilic inflammation in asthmatic adults and children [8,9]. …”

Section: Introductionsupporting

confidence: 71%

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Exhaled Breath Temperature Increases during Mild Exacerbations in Children with Virus-Induced Asthma

Xepapadaki

Xatziioannou²,

Chatzicharalambous³

et al. 2010

Int Arch Allergy Immunol

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Background: Exhaled breath temperature (EBT) has been suggested as a non-invasive surrogate marker of airway inflammation in asthma. The aim of the study was to evaluate differences in EBT between periods of controlled disease and during exacerbations in children with virus-induced asthma. Methods: Twenty-nine children (aged 6–14 years) with a history of intermittent, virus-induced asthma were included in this case-control study. Cases presented with a common cold and/or mild exacerbation of asthma, while controls were free of asthmatic or common cold symptoms during the previous 6 weeks. A baseline questionnaire was obtained. Atopy assessment, central temperature and a spirometric measurement were recorded. EBT was measured with a new device (Delmedica, Singapore). A nasal wash (for identification of common respiratory viruses) was obtained. Results: Twenty-four children (12 from each group) completed the study. Groups were homogeneous with respect to baseline characteristics. PCR revealed the presence of a virus in 3 out of 17 controls and 10 out of 12 cases (17.6 and 83.3%, respectively, p = 0.002). The most commonly identified virus was rhinovirus (3/3 controls and 7/10 cases, p = 0.02). EBT values were significantly higher for cases (34.91 ± 0.62°C) compared to controls (34.18 ± 1.1°C, p = 0.032). No important differences were observed in the increase rate of EBT (Δe°T) between groups. Conclusions: Changes in airway inflammation during virus-induced asthma exacerbations are reflected in EBT changes. These preliminary data suggest a possible role of EBT measurements in the assessment of airway inflammation in children with virus-induced asthma.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionsupporting

confidence: 71%

Exhaled Breath Temperature Increases during Mild Exacerbations in Children with Virus-Induced Asthma

Xepapadaki

Xatziioannou²,

Chatzicharalambous³

et al. 2010

Int Arch Allergy Immunol

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“…Also, elevated respiratory heat and moisture loss have been found to correlate with sputum eosinophil percentage in asthmatic subjects, giving further support to the role for thermal measurements in assessing the increased airway mucosal blood flow associated with airway inflammation [29]. Further studies are necessary to specify in more detail the influence of ambient temperature on EBT when using the tidal breathing technique.…”

Section: Discussionmentioning

confidence: 87%

Exhaled breath temperature in children: reproducibility and influencing factors

et al. 2014

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“…In fact, the authors of several earlier studies [15,16,17,18,19,20,21] have reported that there are relationships between leukocytic changes and heat stimulus. In particular, Resnik et al [21] concluded that heat stress is related to degranulation of the basophil leukocytes.…”

Section: Resultsmentioning

confidence: 99%

Inferring Genes and Biological Functions That Are Sensitive to the Severity of Toxicity Symptoms

Kim¹,

Shin²

2017

IJMS

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The effective development of new drugs relies on the identification of genes that are related to the symptoms of toxicity. Although many researchers have inferred toxicity markers, most have focused on discovering toxicity occurrence markers rather than toxicity severity markers. In this study, we aimed to identify gene markers that are relevant to both the occurrence and severity of toxicity symptoms. To identify gene markers for each of four targeted liver toxicity symptoms, we used microarray expression profiles and pathology data from 14,143 in vivo rat samples. The gene markers were found using sparse linear discriminant analysis (sLDA) in which symptom severity is used as a class label. To evaluate the inferred gene markers, we constructed regression models that predicted the severity of toxicity symptoms from gene expression profiles. Our cross-validated results revealed that our approach was more successful at finding gene markers sensitive to the aggravation of toxicity symptoms than conventional methods. Moreover, these markers were closely involved in some of the biological functions significantly related to toxicity severity in the four targeted symptoms.

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Respiratory heat and moisture loss is associated with eosinophilic inflammation in asthma

Cited by 15 publications

References 28 publications

Exhaled Breath Temperature Increases during Mild Exacerbations in Children with Virus-Induced Asthma

Exhaled Breath Temperature Increases during Mild Exacerbations in Children with Virus-Induced Asthma

Exhaled breath temperature in children: reproducibility and influencing factors

Inferring Genes and Biological Functions That Are Sensitive to the Severity of Toxicity Symptoms

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