Respiratory Health in Prematurely Born Preschool Children with and without Bronchopulmonary Dysplasia

Vrijlandt, Elianne J.L.E.; Boezen, H. Marike; Gerritsen, Jorrit; Stremmelaar, E.F.; Duiverman, Eric J.

doi:10.1016/j.jpeds.2006.12.007

Cited by 160 publications

(163 citation statements)

References 37 publications

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“…17 Interestingly, Rint values expressed as absolute and z-scores were significantly higher in preterm children in this study (1.16 and 1.00 kPa l À1 s) compared to healthy controls in a recent study (0.70 and 0.0 kPa l À1 s). 26 Thus, Rint is also able to discriminate between prematurely born children without CLD and healthy controls as shown previously. 26 In this study we did not obtain Rint measurements before and after bronchodilator due to the need for repeat measurements in a busy clinic.…”

Section: Discussionsupporting

confidence: 72%

“…26 Thus, Rint is also able to discriminate between prematurely born children without CLD and healthy controls as shown previously. 26 In this study we did not obtain Rint measurements before and after bronchodilator due to the need for repeat measurements in a busy clinic. However, the bronchodilator response did not differ between children with and without CLD in the study by Vrijlandt et al 26 This study may influence future studies investigating longitudinal lung function test in children with CLD and in those using inhaled corticosteroids.…”

Section: Discussionsupporting

confidence: 72%

“…4,25 However, a similar study using the MicroRint device did not show a difference in respiratory resistance between their CLD and preterm control groups. 26 The possible reasons for this observation are that unlike their study group, participants in our study belonged to a younger age group. Also, all the CLD children in our study belonged to the severe category 13 and not only received longer assisted ventilation and oxygen, but were also discharged home receiving supplemental oxygen.…”

Section: Discussionmentioning

confidence: 90%

“…The baseline differences found between the study groups were in accordance with a previous study. 26 Although Rint is related to both age and height 17 its correlation with birthweight and gestation is not known. It is plausible that the baseline difference in neonatal gestation and birth weight in CLD group may be responsible for the increased Rint in this study, though this baseline difference did not influence Rint in the study by Vrijlandt et al 26 Furthermore; anthropometric data including weight, height and corrected age were comparable between the groups at the time of this study.…”

Section: Discussionmentioning

confidence: 99%

“…26 Although Rint is related to both age and height 17 its correlation with birthweight and gestation is not known. It is plausible that the baseline difference in neonatal gestation and birth weight in CLD group may be responsible for the increased Rint in this study, though this baseline difference did not influence Rint in the study by Vrijlandt et al 26 Furthermore; anthropometric data including weight, height and corrected age were comparable between the groups at the time of this study. Interestingly, although duration of oxygen therapy influences spirometry at school age, 5 Rint did not show this relationship in preschool children in this study.…”

Section: Discussionmentioning

confidence: 99%

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Lung function measurement in prematurely born preschool children with and without chronic lung disease

et al. 2008

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Objective: Prematurely born infants often have recurrent wheeze and long-term respiratory morbidity at follow-up. Assessment of airways obstruction in preschool children is feasible using the interrupter resistance (Rint) but has rarely been examined in preterm children with and without chronic lung disease (CLD). The objective of this study was to determine lung function measured by the interrupter technique, its feasibility in the ambulatory setting and respiratory health in prematurely born preschool children with and without CLD.Study Design: Preterm children of 2 to 4 years with severe CLD (>30% oxygen at 36 weeks and discharged home receiving supplemental oxygen) (n ¼ 43, median gestational age 27 weeks and median birth weight 995 g) and without CLD (n ¼ 33, median gestational age 29 weeks and median birth weight 1366 g) attempting lung function test for the first time were enrolled. Respiratory symptoms score was calculated using a questionnaire. A single set of 10 consecutive Rint measurements was obtained using a portable device (MicroRint). Median of at least five occlusions with consistent shape of mouth pressure-time curves was taken to be a Rint measurement. To assess feasibility the children were categorized as 'satisfactory', 'failure' and 'rejected' depending on the outcome of the test. Outcome variables were respiratory symptoms score and Rint.Result: Satisfactory Rint measurement was obtained in 46 (61%) children, 9 (36%) 2-year olds, 17 (65%) 3-year olds and 20 (80%) 4-year olds. As compared with the preterm control children (n ¼ 18), CLD children (n ¼ 28) had significantly higher respiratory symptoms score (18.5 vs 6, P<0.01) and Rint expressed as absolute values (kPa l À1 ) and z-scores (1.33 vs 1.16 and 1.42 vs 1.0, P<0.01), respectively. Conclusion:Rint measurement is feasible in prematurely born children of preschool age in the ambulatory setup. Preschool children with severe CLD may be identified from preterm children without CLD by increased Rint that may be used as a screening tool and as an outcome measure for interventions.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Lung function measurement in prematurely born preschool children with and without chronic lung disease

et al. 2008

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Effect of Inhaled Nitric Oxide on Survival Without Bronchopulmonary Dysplasia in Preterm Infants

et al. 2017

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for the Newborns Treated With Nitric Oxide (NEWNO) Trial Group IMPORTANCE Bronchopulmonary dysplasia (BPD) occurs in approximately 40% of infants born at younger than 30 weeks' gestation and is associated with adverse pulmonary and neurodevelopmental outcomes.OBJECTIVE To test whether administration of inhaled nitric oxide to preterm infants requiring positive pressure respiratory support on postnatal days 5 to 14 improves the rate of survival without BPD. DESIGN, SETTING, AND PARTICIPANTSThis intent-to-treat study was a randomized clinical trial performed at 33 US and Canadian neonatal intensive care units. Participants included 451 neonates younger than 30 weeks' gestation with birth weight less than 1250 g receiving mechanical ventilation or positive pressure respiratory support on postnatal days 5 to 14. Enrollment spanned from December 23, 2009, to April 23, 2012, and neurodevelopmental outcome studies were completed by April 4, 2014.INTERVENTIONS Placebo (nitrogen) or inhaled nitric oxide initiated at 20 ppm was decreased to 10 ppm between 72 and 96 hours after starting treatment and then to 5 ppm on day 10 or 11. Infants remained on the 5-ppm dose until completion of therapy (24 days). MAIN OUTCOMES AND MEASURESThe primary outcome was the rate of survival without BPD at 36 weeks' postmenstrual age (PMA). Secondary outcomes included BPD severity, postnatal corticosteroid use, respiratory support, survival, and neurodevelopmental outcomes at 18 to 24 months' PMA. RESULTS In total, 222 infants (52.3% male [n = 116]) received placebo, and 229 infants (50.2% male [n = 115]) received inhaled nitric oxide. Their mean (SD) gestation was 25.6 (1.5) vs 25.6 (1.4) weeks, and their mean (SD) birth weight was 750 (164) vs 724 (160) g. Survival without BPD at 36 weeks' PMA was similar between the placebo and inhaled nitric oxide groups (31.5% [n = 70] vs 34.9% [n = 80]) (odds ratio, 1.17; 95% CI, 0.79-1.73). Rates for severe BPD (26.6% [55 of 207] vs 20.5% [43 of 210]) and postnatal corticosteroid use for BPD (41.0% [91 of 222] vs 41.5% [95 of 229]) and the mean (SD) days of positive pressure respiratory support (55 [40] vs 54 [42]), oxygen therapy (88 [41] vs 91 [59]), and hospitalization (105 [37] vs 108 [54]) were equivalent between the 2 groups. No differences in the incidence of common morbidities were observed. Respiratory outcomes on discharge to home, at 1 year, and at age 18 to 24 months' PMA and neurodevelopmental assessments at 18 to 24 months' PMA did not differ between groups.CONCLUSIONS AND RELEVANCE Inhaled nitric oxide, initiated at 20 ppm on postnatal days 5 to 14 to high-risk preterm infants and continued for 24 days, appears to be safe but did not improve survival without BPD at 36 weeks' PMA or respiratory and neurodevelopmental outcomes at 18 to 24 months' PMA.

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Final kissing balloon inflation by classic crush stenting did not improve the clinical outcomes for the treatment of unprotected left main bifurcation lesions: The importance of double‐kissing crush technique

Chen

Zhang

et al. 2008

Cathet Cardio Intervent

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Respiratory Health in Prematurely Born Preschool Children with and without Bronchopulmonary Dysplasia

Cited by 160 publications

References 37 publications

Lung function measurement in prematurely born preschool children with and without chronic lung disease

Lung function measurement in prematurely born preschool children with and without chronic lung disease

Effect of Inhaled Nitric Oxide on Survival Without Bronchopulmonary Dysplasia in Preterm Infants

Final kissing balloon inflation by classic crush stenting did not improve the clinical outcomes for the treatment of unprotected left main bifurcation lesions: The importance of double‐kissing crush technique

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