Respiratory complications of obesity

Jubber, Akeel

doi:10.1111/j.1368-5031.2004.00166.x

Cited by 103 publications

(84 citation statements)

References 95 publications

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“…Some authors [32][33][34][35] have reported that the reduction in respiratory muscle strength in obese subjects in their studies was probably caused by reductions in thoracic compliance. The adipose tissue deposited in the thorax and abdomen of obese individuals promotes mechanical compression of the thoracic cavity, which leads to decreased compliance.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of reduced respiratory muscle strength in institutionalized elderly people

et al. 2009

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CONTEXT AND OBJECTIVES: Respiratory muscle strength is relevant to the clinical situation of elderly patients, particularly those presenting with respiratory or cardiac diseases. The objectives of this study were to evaluate the respiratory muscle strength of institutionalized elderly women, compare this with predicted values for the Brazilian population and calculate the correlation with age and anthropometric characteristics. os subgrupos e também com os preditos para a população brasileira. Análise de correlação foi aplicada para a idade, peso, altura e índice de massa corpórea com os valores das pressões respiratórias máximas. O nível de significância adotado foi P < 0,05. RESULTADOS:Não houve diferenças significativas das pressões respiratórias máximas entre os três subgrupos. Em relação aos valores preditos, as pressões respiratórias máximas obtidas foram significativamente menores nos três subgrupos. Correlações negativas entre as pressões respiratórias máximas e a idade e positivas em relação ao peso, altura e índice de massa corpórea foram encontradas. CONCLUSÕES:A força muscular respiratória é marcantemente reduzida em idosas asiladas de 60 a 89 anos, havendo correlação das pressões respiratórias máximas com a idade e com as características antropométricas.NÚMERO DE REGISTRO DE ENSAIO CLÍNICO: ACTRN12608000136303.

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Section: Discussionmentioning

confidence: 99%

Prevalence of reduced respiratory muscle strength in institutionalized elderly people

et al. 2009

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“…There are several possible contributory mechanisms, which have recently been reviewed [27]. The association may be indirectly related due to reflux or a higher intrathoracic pressure on the airways, or through a parallel effect due to lifestyle factors, such as diet, lack of physical activity or socio-economic factors [15].…”

Section: Discussionmentioning

confidence: 99%

Obesity increases the risk of incident asthma among adults

Rönmark

Andersson²,

Nyström³

et al. 2005

European Respiratory Journal

202

164

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The annual incidence of asthma in adults in northern Sweden has been estimated at 2.3 per thousand population. Risk factors for incident asthma among adults were studied in a case-referent study based on incident cases of asthma during 1995-1999.The healthcare providers reported suspected cases of incident asthma. After clinical examination, 309 (65% female) of 473 reported subjects were included. Inclusion criteria were a history of incident asthma (onset ,12 months) and verified bronchial variability. Referents were randomly selected and stratified by age, sex and area of residence.The significant risk factors were hay fever, a family history of asthma, ex-smoking status and elevated body mass index (25.0-29.9 and o30). The risk factor pattern was similar for females and males, and increased body mass index was a significant risk factor for both males and females, as well as for allergic and nonallergic subjects.In conclusion, in addition to hay fever, a family history of asthma, allergic sensitisation and exsmoking status, increased body mass index was a significant risk factor for incident asthma independent of sex and allergic status.

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“…Patients with increased BMI and adiposity also present a higher incidence of surgical site infections, which have been associated with increased risk of other wound complications, increased length of stay, and increased risk of death (4)(5)(6)(7)(8). Obesity also negatively affects pulmonary function and BMI has been correlated to increased susceptibility to communityrelated respiratory tract infections (9)(10)(11)(12).…”

mentioning

confidence: 99%

Diet-Induced Obesity Impairs the T Cell Memory Response to Influenza Virus Infection

Karlsson

Sheridan

Beck

2010

The Journal of Immunology

211

190

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The global obesity epidemic combined with yearly influenza outbreaks and potential for a pandemic makes it crucial to determine how protection from influenza differs in an obese host. In contrast to a vaccine antibody response which recognizes surface proteins, memory T cells generated during a primary infection target internal viral proteins and are protective against heterologous strains. As our prior work demonstrated that obese mice have an impaired primary response to influenza virus infection, we hypothesized that obese mice would also have an impaired memory response to a secondary influenza infection. To test this hypothesis, obese and lean mice were infected with influenza X‐31. At 31 days post infection, mice were challenged with a lethal dose of a different strain, influenza A/PR/8. While lean mice were protected from lethal infection, obese mice had 25% mortality, increased lung pathology and virus titers, reduced antiviral cytokine expression, and decreased and delayed adaptive immune cytokine expression following secondary challenge. These results indicate that memory response to influenza in obese mice is significantly altered and ineffective and obesity may hinder the generation or function of these protective cells. These results suggest obese populations are at risk for impaired immune memory response, which has significant public health implications for current vaccination protocols. Grant Funding Source DK56350

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Respiratory complications of obesity

Cited by 103 publications

References 95 publications

Prevalence of reduced respiratory muscle strength in institutionalized elderly people

Prevalence of reduced respiratory muscle strength in institutionalized elderly people

Obesity increases the risk of incident asthma among adults

Diet-Induced Obesity Impairs the T Cell Memory Response to Influenza Virus Infection

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