Obesity increases the risk of incident asthma among adults

Rönmark, Eva; Andersson, Charlotte; Nyström, Lennarth; Forsberg, Bertil; Järvholm, Bengt; Lundbäck, Bo

doi:10.1183/09031936.05.00054304

Cited by 202 publications

(185 citation statements)

References 29 publications

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“…Suboptimal treatment outcomes in patients with risk factors for poor asthma control have been suggested to be associated with insuf ficient drug deposition in the small airways. 32,33 It is important because the small airways seem to be particularly affected both in smoking and obese asthmatics. Apart from the disturbances in ventilatory function of the lungs in this group of patients, the tendency of the small airways to clo sure has been also emphasized.…”

Section: Resultsmentioning

confidence: 99%

Asthma control in adult patients treated with a combination of inhaled corticosteroids and long-acting beta-2 agonists: a prospective observational study

Rogala¹,

Majak²,

Glück³

et al. 2017

Polish Archives of Internal Medicine

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Section: Resultsmentioning

confidence: 99%

Asthma control in adult patients treated with a combination of inhaled corticosteroids and long-acting beta-2 agonists: a prospective observational study

Rogala¹,

Majak²,

Glück³

et al. 2017

Polish Archives of Internal Medicine

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“…Two other population studies have also shown that obesity is a risk for the combination of symptoms plus AHR. 36,37 Up to 15% of the adult population have asymptomatic AHR, 38 representing a substantial population potentially at risk of developing symptoms in the presence of obesity.…”

Section: Perception Of Dyspneamentioning

confidence: 99%

Effect of obesity on breathlessness and airway responsiveness to methacholine in non-asthmatic subjects

et al. 2007

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Background: Obesity is associated with increased prevalence and incidence of asthma, but the mechanism is unknown. Obesity reduces lung volumes, which can increase airway responsiveness, and increases resistive and elastic work of breathing, which can increase dyspnea. Objective: To determine if the intensity of dyspnea due to airway narrowing or if airway responsiveness is increased in obese, non-asthmatic subjects. Subjects: Twenty-three obese (BMI (body mass index) X30 kg m À2 ) and 26 non-obese (BMI o30 kg m À2 ) non-asthmatic subjects, aged between 18 and 70 years. Methods: High-dose methacholine challenge was used to determine the sensitivity and the maximal response to methacholine. Respiratory system resistance (Rrs) and reactance were measured, using the forced oscillation technique, as indicators of resistive and elastic loads during challenge. Perception of dyspnea was measured by the Borg score during challenge. Static lung volumes were measured by body plethysmography. Results: Static lung volumes were reduced in the obese subjects. There were no significant differences in the sensitivity or maximal response to methacholine between obese and non-obese subjects. The magnitude of change in Rrs was similar in both groups, but obese subjects had more negative reactance after challenge (P ¼ 0.002) indicating a greater elastic load. The intensity of dyspnea was greater in obese subjects (P ¼ 0.03). Conclusions: Obesity reduces lung volumes, but does not alter the sensitivity or maximal response to methacholine. However, obese subjects have enhanced perception of dyspnea, associated with greater apparent stiffness of the respiratory system, and may therefore be at greater risk of symptoms.

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“…A clear explanation for the rising rates and associated risks of pediatric asthma and obesity remains elusive. Numerous studies have reported an association between asthma and obesity in adult and pediatric cohorts (16)(17)(18)(19). Sex differences, with stronger associations documented among women, have been observed, although not consistently (16,17).…”

Section: Introductionmentioning

confidence: 97%