Respiratory Bronchiolitis With Fibrosis–Interstitial Lung Disease: A New Form of Smoking-Induced Interstitial Lung Disease

Churg, Andrew; Hall, Rebecca; Bilawich, Ana-Maria

doi:10.5858/arpa.2014-0248-ed

Cited by 18 publications

(8 citation statements)

References 16 publications

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“…The most frequent aspects of SRIF on HRCT are micronodular infiltrates and GGO. In some cases, SRIF has a distinctive radiological aspect on HRCT and consists of sharply circumscribed upper zonal and mid‐zonal sub‐pleural foci of emphysema mixed with reticulation sometimes accompanied by areas of GGO . As opposed to RB/RB‐ILD, SRIF is often mistaken, either on biopsy or HRCT, for a diffuse fibrosing interstitial pneumonia.…”

Section: How Does Smoking Promote Lung Inflammation and Fibrosis?mentioning

confidence: 99%

Smoking‐related idiopathic interstitial pneumonia: A review

Margaritopoulos

Harari²,

Caminati³

et al. 2015

Respirology

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For many years, cigarette smoking has been considered as the leading cause of chronic obstructive pulmonary disease and lung cancer. Recently, however, it has also been associated with the development of diffuse interstitial lung diseases. In the latest classification of the major idiopathic interstitial pneumonias (IIP), the term smoking-related IIP has been introduced, including two entities, namely desquamative interstitial pneumonia (DIP) and respiratory bronchiolitisinterstitial lung disease (RB-ILD). Other entities in which smoking has a definite or suggested role include pulmonary Langerhan's cell histiocytosis, smokingrelated interstitial fibrosis, combined pulmonary fibrosis and emphysema syndrome and idiopathic pulmonary fibrosis. In this review, we will focus on the mechanisms of smoking-related lung damage and on the clinical aspects of these disorders with the exception of idiopathic pulmonary fibrosis, which will be reviewed elsewhere in this review series.

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Section: How Does Smoking Promote Lung Inflammation and Fibrosis?mentioning

confidence: 99%

Smoking‐related idiopathic interstitial pneumonia: A review

Margaritopoulos

Harari²,

Caminati³

et al. 2015

Respirology

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“…3B. 22,29 These findings at CT result from pigment-laden macrophages accumulating within the bronchioles and alveolar ducts resulting in ill-defined centrilobular nodules. Macrophages within the alveolar spaces result in the centrilobular ground-glass opacities often seen in RB.…”

Section: Respiratory Bronchiolitismentioning

confidence: 99%

“…Macrophages within the alveolar spaces result in the centrilobular ground-glass opacities often seen in RB. 29 Sometimes RB is associated with mild fibrosis of the respiratory bronchioles. 22,29 Although both RB and RB-ILD (Respiratory bronchiolitis-Interstitial Lung Disease) share many features, RB-ILD is classified as an idiopathic interstitial pneumonia and patients present with impairment of lung function and gas exchange; RB is asymptomatic.…”

Section: Respiratory Bronchiolitismentioning

confidence: 99%

“…29 Sometimes RB is associated with mild fibrosis of the respiratory bronchioles. 22,29 Although both RB and RB-ILD (Respiratory bronchiolitis-Interstitial Lung Disease) share many features, RB-ILD is classified as an idiopathic interstitial pneumonia and patients present with impairment of lung function and gas exchange; RB is asymptomatic. 11,22 When patients with RB or RB-ILD stop smoking, findings on CT may regress or stabilize.…”

Section: Respiratory Bronchiolitismentioning

confidence: 99%

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Imaging of Small Airways and Emphysema

Edwards

Kicska

Schmidt

et al. 2015

Clinics in Chest Medicine

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“…A previous study proposed that the combined effect of smoking and dust is an important factor causing a decline in pulmonary function of dust-exposed workers (15). Respirable coal dust concentration in the working area, and cumulative total dust exposure (CTE) is a significant risk factor for abnormal pulmonary function, and a previous study observed that CTE may lead to COPD, including chronic bronchitis and emphysema (2).…”

Section: Introductionmentioning

confidence: 99%

Correlations of smoking with cumulative total dust exposure and cumulative abnormal rate of pulmonary function in coal-mine workers

Qin

Cao

Shen

et al. 2016

Experimental and Therapeutic Medicine

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The present study aimed to investigate the correlation of smoking with cumulative total dust exposure (CTE) and cumulative abnormal rate of pulmonary function in coal-mine workers. A total of 376 coal-mine workers were recruited as the observational group, while 179 healthy workers in other industries were selected as the control group. All the workers underwent pulmonary function testing to determine their forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and FEV1/FVC, in order to compare the abnormal pulmonary function between the two groups. A markedly higher number of smokers was observed in the observational group (200/376, 53.19%) when compared with the control group (72/179, 40.22%). In smokers, the abnormal rate of pulmonary function in the observational group (102/200, 51.00%) was evidently higher compared with that in the control group (19/72, 26.39%), whereas no significant difference was detected between the two groups of non-smokers (P=0.077). In addition, FVC, FEV1 and FEV1/FVC of the observational group were found to be lower compared with those in the control group, in both the smoking and non-smoking subgroups. In the smoking subgroup, FVC and FEV1 in subjects working at the coal mine for different number of years showed significant differences (all P<0.05), whereas comparison of FEV1/FVC in workers with different working durations showed no significant difference (P=0.169). However, in the non-smoking subgroup, the comparison of FVC, FEV1 and FEV1/FVC in different working duration groups also showed no significant difference (all P>0.05). Furthermore, FVC, FEV1 and FEV1/FVC in smoking coal-mine workers were negatively correlated with the dust-exposure working duration (P<0.05). CTE was also positively correlated with cumulative abnormal rate of pulmonary function in the smoking and non-smoking subgroups, while FEV1 was negatively correlated with CTE in the smoking subgroup (P=0.009). In conclusion, smoking is an important risk factor for the damage of pulmonary function in coal-mine workers, and it is positively correlated with dust-exposure time and CTE in these individuals.

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Respiratory Bronchiolitis With Fibrosis–Interstitial Lung Disease: A New Form of Smoking-Induced Interstitial Lung Disease

Cited by 18 publications

References 16 publications

Smoking‐related idiopathic interstitial pneumonia: A review

Smoking‐related idiopathic interstitial pneumonia: A review

Imaging of Small Airways and Emphysema

Correlations of smoking with cumulative total dust exposure and cumulative abnormal rate of pulmonary function in coal-mine workers

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