Respiratory arrest after epidural sufentanil

Blackburn, Christine Crudo

doi:10.1111/j.1365-2044.1987.tb03098.x

Cited by 26 publications

(7 citation statements)

References 1 publication

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“…Peak plasma levels of sufentanil are reached within minutes after an epidural injection (26), possibly causing respiratory depression. This serious side‐effect has been observed after high single doses (27, 28). In our study similar Apgar scores, NAC scores and umbilical blood‐gas values were observed in the three groups.…”

Section: Discussionmentioning

confidence: 99%

Epidural ropivacaine 1% with and without sufentanil addition for Caesarean section

Bachmann-Mennenga

Veit

Biscoping

et al. 2005

Acta Anaesthesiol Scand

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Section: Discussionmentioning

confidence: 99%

Epidural ropivacaine 1% with and without sufentanil addition for Caesarean section

Bachmann-Mennenga

Veit

Biscoping

et al. 2005

Acta Anaesthesiol Scand

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“…After intrathecal opioids, respiratory depression develops 6-11 h after administration and may last for as long as 23 h [60]. After extradural opioids, respiratory depression can occur within 1 h, and in just a few minutes with the more fat soluble drugs [23,192], although most instances have been delayed for 4-6 h. A delay of 16.5 h has been reported [202]. Morphine is almost invariably the drug involved.…”

Section: Respiratory Depressionmentioning

confidence: 99%

“…It is pertinent to note with regard to this case that the nurse had actually left the patient's room, but fortunately the husband drew attention to the problem. Extradural sufentanil has been followed within a few minutes by respiratory depression [23,192].…”

Section: Incidencementioning

confidence: 99%

The Rational Use of Intrathecal and Extradural Opioids

Morgan

1989

British Journal of Anaesthesia

199

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“…Although early respiratory depression, i.e. within 5-10 min after epidural administration of 50 pg sufentanil, has been reported (23)(24)(25), this effect could not be studied in our patients, since they were ventilated for about 12 h postoperatively. However, we were interested to assess signs of late respiratory depression, i.e.…”

Section: Discussionmentioning

confidence: 85%

Does epidural sufentanil provide effective analgesia per‐and postoperatively for abdominal aortic surgery?

Broekema¹,

Kuizenga²,

Hennis³

1996

Acta Anaesthesiol Scand

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To assess the efficacy of epidural sufentanil in providing per- and postoperative analgesia, 40 patients undergoing elective abdominal aortic surgery received either 50 mu g sufentanil in 10 ml normal saline solution (n = 20, ES group) or 10 ml normal saline (n = 20, control group) via a thoracic epidural catheter. The study solution was given (double-blind and at random) after the patients had been anaesthetized with i.v. midazolam, sufentanil and vecuronium. Anaesthesia was maintained with 60% nitrous oxide in oxygen and halothane at a 1% inspiratory concentration. When patients showed signs of inadequate analgesia, supplementary doses of 25 mu g sufentanil were given i.v. The number of patients requiring additional i.v. sufentanil differed significantly between the two groups: 5 out of 20 patients in the ES group vs 13 out of 20 patients in the control group required additional sufentanil (P<0.05). The mean dose administered i.v. did not differ significantly between the two groups: 105 +/- 109.5 mu g vs 138.5 +/- 126.9 mu g (mean +/- SD) in 5 and 13 patients, respectively. No cardiovascular changes were observed after the epidural bolus dose. Postoperative analgesia, consisting of a continuous epidural infusion of 50 mu g sufentanil in 50 ml bupivacaine 0.125% at a rate of 6-10 ml/h after a bolus dose of 10 ml of this solution, was adequate in the majority of patients, as determined by VAS-scores assessed during the epidural treatment (4.3 +/- 1.5 days).

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Respiratory arrest after epidural sufentanil

Cited by 26 publications

References 1 publication

Epidural ropivacaine 1% with and without sufentanil addition for Caesarean section

Epidural ropivacaine 1% with and without sufentanil addition for Caesarean section

The Rational Use of Intrathecal and Extradural Opioids

Does epidural sufentanil provide effective analgesia per‐and postoperatively for abdominal aortic surgery?

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