Drug Delivery Systems for Tuberculosis Prevention and Treatment 2016
DOI: 10.1002/9781118943182.ch14
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Respirable Bacteriophage Aerosols for the Prevention and Treatment of Tuberculosis

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Cited by 9 publications
(12 citation statements)
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“…The development of regulatory-approved, commercial phage formulations for inhalation will likely require the use of cocktails containing various phages that target different receptors to ensure that M. tuberculosis does not become phage resistant (17). The development of anti-TB cocktails is an active area of research (17). Phage D29 and others that may be included in a therapeutic cocktail would be applicable for the prevention of drug-sensitive or drug-resistant strains of M. tuberculosis.…”
Section: Discussionmentioning
confidence: 99%
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“…The development of regulatory-approved, commercial phage formulations for inhalation will likely require the use of cocktails containing various phages that target different receptors to ensure that M. tuberculosis does not become phage resistant (17). The development of anti-TB cocktails is an active area of research (17). Phage D29 and others that may be included in a therapeutic cocktail would be applicable for the prevention of drug-sensitive or drug-resistant strains of M. tuberculosis.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, antibiotic resistance does not influence bacterial susceptibility to phage lysis (16), making phages an attractive tool against drug-resistant organisms. Phages predicted to use obligatory lytic life cycles can be distinguished from temperate phages through genetic analysis (17). The lytic cycle encompasses the injection of phage DNA into the cell, phage replication, and lysis of the bacterial cell wall to release the progeny.…”
mentioning
confidence: 99%
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“…Phages present an alternative resource in combating bacteria-related diseases (Kutateladze and Adamia, 2010). Phages are viruses that infect bacteria and can have a narrow host range of target bacteria (Hatful and Vehring, 2016; Dewangan et al, 2017). This narrow host range results in little to no off target effects, unlike what is seen with conventional antibiotics which often damage microbiota (Loc-Carrillo and Abedon, 2011; Dewangan et al, 2017).…”
Section: Introductionmentioning
confidence: 99%
“…There are many phages with varying structures, one of which consists of a polyhedral capsid containing genetic material and a tail used to bind to the bacteria and inject the genetic material (Hatful and Vehring, 2016; Dewangan et al, 2017). Although not all phages can be used as therapeutic agents, lytic phages tend to be the most useful, due to their exponential growth and effectiveness in eradicating the host bacteria (Kutateladze and Adamia, 2010).…”
Section: Introductionmentioning
confidence: 99%