Resorption of, and bone formation from, new ?-tricalcium phosphate-monocalcium phosphate cements: Anin vivo study

Abstract

Hard cylinders (4.7 x 10 mm) of two kinds of beta-tricalcium phosphate-monocalcium phosphate monohydrate-calcium sulfate hemihydrate (beta-TCP-MCPM-CSH) cements with and without beta-TCP granules (500-1000 microns) were implanted into holes drilled in rabbit femoral condyles for up to 16 weeks. Empty cavities were used as control. Cement resorption and new bone formation in the cylinders were evaluated with contact microradiography and quantified through an automatic image analysis system. At 4 weeks, both kinds of cement cylinders were surrounded by new bone. At 8 weeks, except for beta-TCP granules, both cement cylinders were almost completely resorbed and replaced by bone tissue. At 16 weeks the bone in the cavities of both cements recovered a trabecular pattern, but only the bone trabeculae in the initial cavity of the cement with beta-TCP granules became thick and mature. However, the cavities of the empty control were still empty and large. These results show that the beta-TCP-MCPM-CSH cements stimulate bone formation and are rapidly replaced by bone tissue. When added with nonresorbable beta-TCP granules, this cement maintains bone formation for a longer time.

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

“…However, the following values were found: 25.7 ± 0.1 (pH = 7.40), 29.9 ± 0.1 (pH = 6.00), 32.7 ± 0.1 (pH = 5.28) (Ohura et al 1996). The comparative extent of dissolution in acidic buffer is: ACP ) a-TCP ) b-TCP [ CDHA ) HA [ FA (Daculsi et al 1997) (Becker 1989;Rakovan and Pasteris 2015;Cook et al 2005;Dumoulin et al 2011).…”

Effect of preparation conditions on the nanostructure of hydroxyapatite and brushite phases

“…Within bone matrix, calcium is important at the whole tissue level, both as a structural component of the mineralized matrix and as a signal transduction molecule for eliciting cellular responses. Owing to its closed structural resemblance to bones and teeth, HAP has attracted much attention as a substitute material for damaged teeth or bones over the last years (Suchanek and Yoshimura 1997;Hench 1991;Ohura et al 1996).…”

The effects of calcium phosphate cement particles on osteoblast functions

“…CPC were well tolerated by the bone cells and could enhance the production of di!erent bone proteins. In vivo experiments on rabbits demonstrated that brushite was resorbed and replaced by newly formed bone within 3 months [2]. During CPC resorption, particle debris were noted around the periphery of the cement [13].…”