Resorcinolic lipids improve the properties of sphingomyelin–cholesterol liposomes

Zant-Przeworska, E.; Stasiuk, Maria; Gubernator, Jerzy; Kozubek, Arkadiusz

doi:10.1016/j.chemphyslip.2010.05.202

Cited by 9 publications

(9 citation statements)

References 42 publications

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“…Liposomes are one of the effective drug carriers due to their ability to reduce drug toxicity and deliver the drugs to specific cells (Torchilin, 2005). The physicochemical behaviors of ARs and their variability in structures were reported for their suitability as effective drug delivery systems (Zant-Przeworska, Stasiuk, Gubernator, & Kozubek, 2010). The studies of Liu et al (2012) suggested that the AR fractions such as 5-heptadecylresorcinol (IC50 = 22.5l g/mL), 5-(16-heneicosenyl) resorcinol (trans) (IC50 = 13.7l g/mL), 5-(14-nonadecenyl)resorcinol (trans) (IC50 = 42.2l g/mL), and 5-(2-oxotricosanyl) resorcinol (IC50 = 10.91 g/mL) showed high cytotoxicity against human prostate adenocarcinoma (PC3) cells at the IC50 concentration of 22.5, 13.7, 42.2 and 10.9 µg/mL (Landberg, Kamal-Eldin, Andersson, Vessby, & Åman, 2008).…”

Section: Bioactivity Of Arsmentioning

confidence: 99%

Bioactive phytochemicals in wheat: Extraction, analysis, processing, and functional properties

Luthria

John

2015

Journal of Functional Foods

105

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Available online A B S T R A C TWhole wheat provides a rich source of bioactive phytochemicals namely, phenolic acids, carotenoids, tocopherols, alkylresorcinols, benzoxazinoids, phytosterols, and lignans. This review provides information on the distribution, extractability, analysis, and functional properties of bioactive phytochemicals present in wheat. Understanding the impact of processing on wheat phytochemicals allows us to develop improved processes with higher retention of bioactive compounds in processed wheat foods. Details of extraction, analytical methodologies and processing effects on bioactive phytochemicals in wheat are presented in tabulated form.Published by Elsevier Ltd.

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Section: Bioactivity Of Arsmentioning

confidence: 99%

Bioactive phytochemicals in wheat: Extraction, analysis, processing, and functional properties

Luthria

John

2015

Journal of Functional Foods

105

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“…Below CMC value, lipid molecules exist as monomers dispersed in water, whereas above CMC value lipid molecules tend to self-associate, forming micelles, bilayers, or other aggregates. The CMC, which is greater for charged molecules than for uncharged molecules [1], decreases significantly in conjunction with decreases in the length of the fatty acid chains [5]. Lipids with relatively weak headgroups (i.e., with weak opposing forces) form bilayer-like aggregates, such as vesicles, and disc-like micelles [6].…”

Section: Amphiphilic Molecules Self-assembly and Critical Micelle Conmentioning

confidence: 99%

Dynamics of Model Membranes by NMR

Timoszyk¹

2017

Spectroscopic Analyses - Developments and Applications

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Amphiphilic molecules can create various aggregates in water. Concern about exploring such structures has been unabated for several decades due to the wide range of possible applications of lipid aggregates, from food technology to the pharmaceutical industry. The form of self-assembled structures depends on many factors, such as the type of amphiphilic molecule, the concentration, the level of hydration, the temperature, and the pH. Liposomes and micelles are the most widely known types of closed structures. Liposomes are more often used in the fields of medicine and pharmacy because they consist of nontoxic compounds and their composition and size can be controlled. Nuclear magnetic resonance (NMR) is one of the methods, which is most commonly used to study liposome properties. It can be used to observe changes in the structure, dynamics, and phase transition of lipid membranes. The membrane properties are changed under the influence of external factors, such as temperature, pH, and the presence of ions or drugs. The chapter aims to introduce and discuss the possibilities of the most useful NMR methods, 31 P and 1 H, to study the liposome properties. It also aims to show how various changes in the structure or dynamics of lipid molecules are visible in the NMR spectra.

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“…4,[16][17][18] In addition to PEG, long-circulating liposomes could also be obtained by incorporating ganglioside GM1, phosphatidylinositol, polysaccharides, or polyvinyl alcohol into the surface. [19][20][21] Currently, polysaccharides are assumed to have potential for developing a long-circulating system. 22 Increased attention has been paid to chitosan because of its attractive biodegradability, biocompatibility, nontoxicity, and low cost.…”

Section: Introductionmentioning

confidence: 99%

The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate

Zhang

Chen

Li³

et al. 2016

IJN

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Purpose This study was designed to improve the in vivo pharmacokinetics of long-circulating vincristine sulfate (VS)-loaded liposomes; three different long-circulating materials, chitosan, poly(ethylene glycol)-1,2-distearoyl sn-glycero-3-phosphatidylethanolamine (PEG-DSPE), and poly(ethylene glycol)-poly-lactide- co -glycolide (PEG-PLGA), were evaluated at the same coating molar ratio with the commercial product Marqibo ® (vincristine sulfate liposome injection [VSLI]). Materials and methods VS-loaded liposomes were prepared by a pH gradient method and were then coated with chitosan, PEG-DSPE, or PEG-PLGA. Physicochemical properties, including the morphology, particle size, zeta potential, encapsulation efficiency (EE%), pH, drug loading, and in vitro release, were determined. Preservation stability and pharmacokinetic studies were performed to compare the membrane-coated liposomes with either commercially available liposomes or the VS solution. Results The sphere-like morphology of the vesicles was confirmed by transmission electron microscope. Increased particle size, especially for the chitosan formulation, was observed after the coating process. However, the EE% was ~99.0% with drug loading at 2.0 mg/mL, which did not change after the coating process. The coating of long-circulation materials, except for chitosan, resulted in negatively charged and stable vesicles at physiological pH. The near-zero zeta potential exhibited by the PEG-DSPE formulation leads to a longer circulation lifetime and improved absorption for VS, when compared with the PEG-PLGA formulation. Compared with the commercial product, PEG was responsible for a higher plasma VS concentration and a longer half-life. Conclusion PEG-DSPE coating may be related to better absorption, based on the stability and a pharmacokinetic improvement in the blood circulation time.

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Resorcinolic lipids improve the properties of sphingomyelin–cholesterol liposomes

Cited by 9 publications

References 42 publications

Bioactive phytochemicals in wheat: Extraction, analysis, processing, and functional properties

Bioactive phytochemicals in wheat: Extraction, analysis, processing, and functional properties

Dynamics of Model Membranes by NMR

The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate

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