Resorcin[4]arenes: Generalities and Their Role in the Modification and Detection of Amino Acids

Abstract

: The characteristics and properties that enable resorcin[4]arenes to self-assemble to form derivatives with amino acids with a high potential for application in various fields are reviewed. In particular, resorcin[4]arene synthesis, their characteristics, the variety in the size of the cavity, their functional groups, and their applications associated with molecular interactions are described. Also, the types of amino acids that can be recognized by resorcin[4]arenes, their interactions, the techniques that allow the determination of the association constants, and the evaluation of the stoichiometry of the complex formed are reviewed.

Supramolecular 3 in 1: A Lubrication and Co-Delivery System for Synergistic Advanced Osteoarthritis Therapy

“…The resorcin [4]arene skeleton was selected for its facile synthesis and potential for functionalized modification. 72 Compared to traditional resorcin [4]arene, CV-2 and carboxylmodified cavitand (CV-1) 73 possess a deep cavity, which benefits from their high recognition capacity to various drugs. Alkyl chains with zwitterionic groups (N + (CH 3 ) 2 and CO 2 − ) and carboxyl groups (CO 2 − ) were modified at the lower rim of CV-2 and CV-1, respectively (Figure 2A).…”

“…Supramolecular chemistry offers a powerful approach to constructing combination therapy with sophisticated molecular design serving as a foundation. The resorcin[4]­arene skeleton was selected for its facile synthesis and potential for functionalized modification . Compared to traditional resorcin[4]­arene, CV-2 and carboxyl-modified cavitand (CV-1) possess a deep cavity, which benefits from their high recognition capacity to various drugs.…”

Copper(I)-Catalyzed Alkyne–Azide Cycloaddition (CuAAC) “Click” Reaction: A Powerful Tool for Functionalizing Polyhydroxylated Platforms

“…Calixarenes can be functionalized in the aromatic ring from the starting materials by varying the nature of the substituent group on the phenol or in the hydroxyl group, − while the reactivity of the resorcin[4]­arenes is mainly located at three points: on the hydroxyl groups, at position 2 of the hydroxyl group, and by modification through the introduction of functionalized aldehyde. ,− Functionalizing substances such as diazonium salts, − methyl sulfonates, , ammonium groups, , acylation, , formylation, , and aminomethylation, among others, , can be introduced into the hydroxylated platform by means of easily accessible reactions selectively, with good yields (Figure ). …”

New Contributions to the Study of the Interaction between Hydrocortisone and Hydroxypropyl-Cyclodextrins in Aqueous Solution

“…Continuing with our research on polyhydroxylated platforms [17][18][19][20], in this article the complexing capacity of three macrocycles systems: 2-hydroxypropyl-α-cyclodextrin, 2hydroxypropyl-β-cyclodextrin and 2-hydroxypropyl-γ-cyclodextrin, with hydrocortisone (Figure 1) were evaluated. The formed complexes were analyzed by using FT-IR and 1 H-NMR spectroscopy.…”