Resorbable implants in pediatric fracture treatment

Grün, Nicole G.; Holweg, Patrick; Donohue, Nicholas; Klestil, Thomas; Weinberg, Annelie

doi:10.1515/iss-2018-0006

Cited by 17 publications

(31 citation statements)

References 37 publications

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“… 39 Too slow a resorption rate may result in increased inflammatory response and fibrosis. 1 Thus, a great number of different Mg alloys have been proposed and tested and studies are still ongoing.…”

Section: Discussionmentioning

confidence: 99%

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Use of resorbable magnesium screws in children: Systematic review of the literature and short-term follow-up from our series

Baldini

Coppa

Falcioni

et al. 2021

Journal of Children's Orthopaedics

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Purpose Biodegradable implants are of major interest in orthopaedics, especially in the skeletally immature population. Magnesium (Mg) implants are promising for selected surgical procedure in adults, but evidence is lacking. Thus, the aim of this study is to analyze the safety and efficacy of resorbable Mg screw in different orthopaedic procedures in skeletally immature patients. In addition, we present a systematic review of the current literature on the clinical use of Mg implants. Methods From 2018 until the writing of this manuscript, consecutive orthopaedic surgical procedures involving the use of Mg screws performed at our centre in patients < 15 years of age were retrospectively reviewed. In addition, a systematic review of the literature was performed in the main databases. We included clinical studies conducted on humans, using Mg-alloy implants for orthopaedic procedures. Results A total of 14 patients were included in this retrospective analysis. Mean age at surgery was 10.8 years (sd 2.4), mean follow-up was 13.8 months (sd 7.5). Healing was achieved in all the procedures, with no implant-related adverse reaction. No patients required any second surgical procedure. The systematic review evidenced 20 clinical studies, 19 of which conducted on an adult and one including paediatric patients. Conclusion Evidence on resorbable Mg implants is low but promising in adults and nearly absent in children. Our series included apophyseal avulsion, epiphyseal fractures, osteochondritis dissecans, displaced osteochondral fragment and tendon-to-bone fixation. Mg screws guaranteed stable fixation, without implant failure, with good clinical and radiological results and no adverse events. Level of evidence IV – Single cohort retrospective analysis with systematic review

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Section: Discussionmentioning

confidence: 99%

“…For this reason, a progressive interest has been shown on biodegradable materials, which do not require further surgery for their removal. 1 …”

Section: Introductionmentioning

confidence: 99%

Use of resorbable magnesium screws in children: Systematic review of the literature and short-term follow-up from our series

Baldini

Coppa

Falcioni

et al. 2021

Journal of Children's Orthopaedics

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“…Biodegradable implants and their beneficial properties are now studied in the field of pediatric traumatology. The materials utilized become reabsorbed within the body in a matter of weeks to years, preventing kids from having unneeded procedures later on in life [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…to consider is the time it takes for the implant to resorb. Some biomaterials have been shown to degrade over the course of weeks to years [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Resorbable Orthopedic Implants in Pediatric Patients: A Narrative Review

Truong¹

2021

GJOR

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The purpose of this article is to review a variety of resorbable orthopedic implants in the pediatric population. Biodegradable implants are now being widely utilized for fracture stabilization in orthopedic surgery. These materials eventually dissolve in the body, not having to perform removal operation, as is done for synthetic-based implants. The current argument in the pediatric surgical community is whether nonresorbable implants can be replaced by resorbable ones. Numbers of biodegradable polymers have been approved and safely used for fracture fixation in children. There are many potential benefits of using resorbable implants: no secondary operation for implant removal, shorter hospital stays, lessened psychological stress, and decreased risk of tissue damage have been discussed.

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3D‐Printed Regenerative Magnesium Phosphate Implant Ensures Stability and Restoration of Hip Dysplasia

Golafshan

Willemsen

Kadumudi

et al. 2021

Adv Healthcare Materials

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Osteoarthritis of the hip is a painful and debilitating condition commonly occurring in humans and dogs. One of the main causes that leads to hip osteoarthritis is hip dysplasia. Although the current surgical methods to correct dysplasia work satisfactorily in many circumstances, these are associated with serious complications, tissue resorption, and degeneration. In this study, a one‐step fabrication of a regenerative hip implant with a patient‐specific design and load‐bearing properties is reported. The regenerative hip implant is fabricated based on patient imaging files and by an extrusion assisted 3D printing process using a flexible, bone‐inducing biomaterial. The novel implant can be fixed with metallic screws to host bone and can be loaded up to physiological loads without signs of critical permanent deformation or failure. Moreover, after exposing the hip implant to accelerated in vitro degradation, it is confirmed that it is still able to support physiological loads even after losing ≈40% of its initial mass. In addition, the osteopromotive properties of the novel hip implant is demonstrated as shown by an increased expression of osteonectin and osteocalcin by cultured human mesenchymal stem cells after 21 days. Overall, the proposed hip implant provides an innovative regenerative and mechanically stable solution for hip dysplasia treatment.

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Resorbable implants in pediatric fracture treatment

Cited by 17 publications

References 37 publications

Use of resorbable magnesium screws in children: Systematic review of the literature and short-term follow-up from our series

Use of resorbable magnesium screws in children: Systematic review of the literature and short-term follow-up from our series

Resorbable Orthopedic Implants in Pediatric Patients: A Narrative Review

3D‐Printed Regenerative Magnesium Phosphate Implant Ensures Stability and Restoration of Hip Dysplasia

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