Resonance-frequency based electrical impedance spectroscopy and its detection sensitivity to breast lesions

Dhurjaty, Sreeram; Gur, David

doi:10.1117/12.2006380

Cited by 2 publications

(3 citation statements)

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“…Furthermore, inductors are quite temperature sensitive and will also cause changes to the measured resonance frequencies. As a result, the relatively lower reproducibility of applying this REIS technology and system to detect resonance frequency of breasts has been demonstrated and discussed in our previous study [14]. This issue is important and needs to be overcome before this new EIS related technology can be reliably applied to and acceptable in the future clinical practice of breast cancer prescreening.…”

Section: Limitation Of Reismentioning

confidence: 89%

“…Our REIS is significantly different from the conventional EIS. Despite encouraging results from our previous studies [7][8][9][10], we identified a number of technical limitations of current REIS systems [14]. Specifically, REIS suffers from a relatively poor reproducibility and repeatability (on the same patient with multiple tests) due to the perturbations in the placement of electrodes, contact pressure variation on the breast, as well as variations due to temperature and tolerances of the resonating inductor.…”

Section: Introductionmentioning

confidence: 91%

“…This can be performed by using calibrated inductors as described in a previous paper by Dhurjaty, et al [14]. Let this inductance be L1 and the corresponding frequency is f1, which is generated using 5KHZ increments as before [8].…”

Section: Figure 3: a New Paradigm For Dielectric Relaxation Spectroscmentioning

confidence: 99%

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A new paradigm of dielectric relaxation spectroscopy for non-invasive detection of breast abnormalities: a preliminary feasibility analysis

Dhurjaty¹,

Qiu

Tan

et al. 2016

SPIE Proceedings

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In order to improve efficacy of screening mammography, in recent years, we have been investigating the feasibility of applying a resonance-frequency based electrical impedance spectroscopy (REIS) technology to noninvasively detect breast abnormalities that may lead to the development of cancer in the near-term. Despite promising study-results, we found that REIS suffered from relatively poor reproducibility due to perturbations in electrode placement, contact pressure variation on the breast, as well as variation of the resonating inductor. To overcome this limitation, in this study, we propose and analyze a new paradigm of Dielectric Relaxation Spectroscopy (DRS) that measures polarization-lag of dielectric signals in breast-capacitance when excited by the pulses or sine waves. Unlike conventional DRS that operates using the signals at very high frequencies (GHz) to examine changes in polarization, our new method detects and characterizes the dielectric properties of tissue at low frequencies (≤10 MHz) due to the advent of inexpensive oscillators that are accurate to 1 pico-second (used in GPS receivers) as well as measurement of amplitudes of 1 ppm or better. From theoretical analysis, we have proved that the sensitivity of new DRS in detecting permittivity of water increased by ≥80 times as compared to conventional DRS, which operates at frequencies around 4GHz. By analyzing and comparing the relationship between the new DRS and REIS, we found that this DRS has potential advantages in enhancing repeatability from various readings, including temperature-insensitive detection, and yielding higher resolution or sensitivity (up to 100 Femtofarads).

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Section: Limitation Of Reismentioning

confidence: 89%