Resolution of optical isomers by capillary zone electrophoresis: Study of enantiomeric and diastereoisomeric Co(III) complexes with ethylenediamine and amino acid ligands

Abstract

Abstract. Capillary electrophoresis (CZE), with hydrodynamic injection and UV detection, was applied to the separation of enantiomeric and diastereoisomeric Co (111) complexes.

Enantiomeric separation of chiral ruthenium(II) complexes using capillary electrophoresis

“…30,[54][55][56][57][58][59][60][61][62] There have been relatively few reports on the enantiomeric separation of transition metal poly(diimine) complexes. 30,[56][57][58][59][60][62][63][64] Chiral additives used for the CE separation of transition metal complexes are usually chiral anions, including carboxymethyl-b-cyclodextrin, 30,[56][57][58][59] tartrate and its derivatives, 30,56,57,59 isocitrate and amino acids derivatives 58 and bile salts. 57,58 In our study, nine cyclodextrin based chiral additives were evaluated by CE and micellar CE for the separation of nine tris(diimine)ruthenium(II) complexes and all stereoisomers of a dinuclear ruthenium(II) tris(diimine) complex (see Fig.…”

Inspection of the reversal of enantiomer migration order in ligand exchange micellar electrokinetic capillary chromatography

“…In our primary experiments (Lin et al, 1997b), we used metal ion-Laspartame complexes as chiral selector for the separation of enantiomers of dansyl amino acids and the under- compared, but only using Cu(II) as the center metal ion for the complex the separation could be carried out. Until now there has only been one report with Co(II) complexes (Fanili et al, 1989). The effect of the ligand of the Cu(II) complexes on the enantioseparation of D,Lphe was also examined.…”

“…Cohen et al (1987) resolved the same group of analytes using gel-filled capillary and N,N-dodecyl-L-alanine complexed Cu (II) ions. Based on the outer-sphere complexation mechanism, the racemic Co(en) 3 3 (en = ethylenediamine) complex cation has been separated into its enantiomers (Fanili et al, 1989). Furthermore, the separation of diastereomeric Co(III)(en) 2 -D,L-phenylalanine complexes has been performed using L-()-tartrate as a chiral selector.…”

Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma‐cyclodextrin as chiral solvating agent

“…2 Capillary electrophoresis (CE) allows the determination of the enantiomers directly from an aqueous solution. 3,4 Whereas isotachophoresis (ITP), 5,6 capillary gel electrophoresis (CGE), 7,8 micellar electrokinetic chromatography (MEKC), 9,10 and capillary electrochromatography (CEC) 11,12 are only occasionally employed for the separation of enantiomers, capillary zone electrophoresis (CZE) 13,14 contributes 74% of the documents, as retrieved from Chirbase/CE (vide infra).…”