Resolution of inflammation-related apoptotic processes by the synthetic tellurium compound, AS101 following liver injury

Multifunctional Activity of a Small Tellurium Redox Immunomodulator Compound, AS101, on Dextran Sodium Sulfate-induced Murine Colitis

“…Furthermore, the proteolytic activity of the inactivated cysteine proteases could be recovered by reducing agents such as NaBH4, further supporting the suggestion that the inactivation process involves oxidation of the catalytic thiol to a disulfide (34). In light of its chemical activities, AS101 has been shown to exert anti-inflammatory and anti-apoptotic effects in different in vivo models (35)(36)(37)(38), through inhibition of caspase 1, 3, and 8 activities and by its ability to induce GDNF production (38,39).…”

“…4C). We previously showed that AS101 is a novel inhibitor of caspase-1 and that it reduces IL-1␤ levels both in vitro and in vivo (35,36). Of note, Siegmund et al (49) found that caspase-1 KO mice exhibit a reduction in clinical manifestations, histology score, and colonic cytokine production in acute or chronic DSS-induced colitis.…”

The effect of the novel tellurium compound AS101 on autoimmune diseases

“…1), currently being evaluated in Phase II clinical trials in psoriasis patients (unpublished data) and in the prevention of bone marrow toxicity induced by chemotherapy in cancer patients [17]. This compound is a potent immunomodulator both in vitro and in vivo with a variety of potential therapeutic applications [7,11,13,14,16,17,25,26]. Accumulated evidence suggests that much of the biological activity of AS101 and other Te IV compounds such as SAS is directly related to its specific chemical interactions with cysteine thiol residues.…”

“…In light of its chemical properties, AS101 has been shown to exert anti-inflammatory activity in various in vivo models [10][11][12][13]28], through the downregulation of IL-1β, IL-17 and IL-6 cytokine levels.…”

“…Anti-inflammatory activity [10][11][12][13] Anti-viral activity [14,15] Chemosensitization of cancer cells [16] Prevention of chemotherapy induced toxicity [17] SAS…”