The effect of the novel tellurium compound AS101 on autoimmune diseases

Halpert, Gilad; Sredni, Benjamin

doi:10.1016/j.autrev.2014.08.003

Cited by 61 publications

(38 citation statements)

References 79 publications

(114 reference statements)

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“…Due to the chemical similarities to tellurium, selenium's heavier congener, tellurium compounds have also attracted interest in the pharmaceutical context [11,12]. Thus, tellurium compounds have shown promise since they are an immunomodulator in organisms [13] and display anti-oxidant [14][15][16], anti-parasitic [17,18] and anti-inflammatory [19] activities, are known to be neuroprotective [20,21] and have potential to be developed as anti-cancer agents [22][23][24]. The most notable tellurium compound that exerts biological activity is found in the salt ammonium trichlorido (dioxyethylene-O,Oꞌ)tellurate, known as AS-101 ( Figure 1a) [25].…”

Section: Introductionmentioning

confidence: 99%

Crystallographic and docking (Cathepsins B, K, L and S) studies on bioactive halotelluroxetanes

Caracelli

Maganhi

Cardoso

et al. 2017

Zeitschrift Für Kristallographie - Crystalline Materials

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Abstract. The molecular structures of the halotelluroxetanes pMeOC6H4Te(X)[C(=C(H)Xꞌ)C(CH2)nO], X = Xꞌ = Cl and n = 6 (1) and X = Cl, Xꞌ = Br and n = 5 (4), show similar binuclear aggregates sustained by { … Te-O}2 cores comprising covalent Te-O and secondary Te⋯O interactions. The resulting C2ClO2(lone-pair) sets define pseudo-octahedral geometries. In each structure, C-X⋯(arene) interactions lead to supramolecular layers. Literature studies have shown these and related compounds (i.e. 2: X = Xꞌ = Cl and n = 5; 3: X = Xꞌ = Br and n = 5) to inhibit Cathepsins B, K, L and S to varying extents. Molecular docking calculations have been conducted on ligands (i.e. cations derived by removal of the telluriumbound X atoms) 1ꞌ-3ꞌ (note 3ꞌ = 4ꞌ) enabling correlations between affinity for sub-sites and inhibition. The common feature of all docked complexes was the formation of a Te-S covalent bond with cysteine residues, the relative stability of the ligands with an E-configuration and the formation of a C-O … π interaction with the phenyl ring; for 1ꞌ the Te-S covalent bond was weak, a result correlating with its low inhibition profile. At the next level differences are apparent, especially with respect to the interactions formed by the organic-ligand-bound halides.

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Section: Introductionmentioning

confidence: 99%

Crystallographic and docking (Cathepsins B, K, L and S) studies on bioactive halotelluroxetanes

Caracelli

Maganhi

Cardoso

et al. 2017

Zeitschrift Für Kristallographie - Crystalline Materials

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“…1,2 Tellurium was considered to be a poison for many years; however, non-toxic substances with high biological activity have been recently found among tellurium compounds including ones with anti-viral, anti-epileptic, antimalarial and glutathione peroxidase-like action. [3][4][5][6][7][8][9] Several discoveries have been recently made which renewed interest in organotellurium chemistry. [3][4][5][6][7][8][9] Bioincorporation of telluromethionine provides a new approach to add heavy atoms to selected sites in proteins.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9] Several discoveries have been recently made which renewed interest in organotellurium chemistry. [3][4][5][6][7][8][9] Bioincorporation of telluromethionine provides a new approach to add heavy atoms to selected sites in proteins. 7 Ammonium trichloro-dioxoethylene-O,O'-tellurate, also known as AS-101 (Figure 1), which can be prepared from tellurium tetrachloride, shows high immune modulating activity.…”

Section: Introductionmentioning

confidence: 99%

“…7 Ammonium trichloro-dioxoethylene-O,O'-tellurate, also known as AS-101 (Figure 1), which can be prepared from tellurium tetrachloride, shows high immune modulating activity. [3][4][5][6][7] It is known that AS-101 is potentially useful in the treatment of clinical immunosuppression conditions including cancer and AIDS. [3][4][5][6][7] A number of addition products of tellurium tetrachloride to unsaturated compounds exhibit high antioxidant, anti-leishmanial (RT-01), anti-epileptic (RF-07) activities, as well as the property of potent inactivation of recombinant human cathepsin B (RT-04) (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6][7] It is known that AS-101 is potentially useful in the treatment of clinical immunosuppression conditions including cancer and AIDS. [3][4][5][6][7] A number of addition products of tellurium tetrachloride to unsaturated compounds exhibit high antioxidant, anti-leishmanial (RT-01), anti-epileptic (RF-07) activities, as well as the property of potent inactivation of recombinant human cathepsin B (RT-04) (Figure 1). [3][4][5][6][7] The distinguishing property of tellurium reagents to react with high regio-and stereo-selectivity finds increasing application in organic synthesis.…”

Section: Introductionmentioning

confidence: 99%

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Highly efficient regioselective synthesis of organotellurium compounds based on the reactions of tellurium tetrachloride with 1-alkenes

Потапов¹,

Мусалова²,

Udalova³

et al. 2017

Arkivoc

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Efficient regioselective syntheses of trichloro-(2-chloroalkyl)-λ 4 -tellanes, trichloro-(2-alkoxyalkyl)-λ 4 -tellanes, bis-(2-alkoxyalkyl)ditellanes and dichlorobis-(2-chloroalkyl)-λ 4 -tellanes in quantitative yields were developed based on tellurium tetrachloride and 1-alkenes (1-hexene and 1-heptene). Favorable conditions for selective preparation of both mono-and bis-adducts of tellurium tetrachloride with 1-alkenes were established. Methoxytelluration was accomplished by the reaction of tellurium tetrachloride with 1-alkenes in CH2Cl2/MeOH at room temperature. Ethoxytelluration was carried out in CH2Cl2/EtOH at reflux. Trichloro-(2-alkoxyalkyl)-λ 4 -tellanes were also obtained by nucleophilic substitution of chlorine atom in trichloro-(2-chloroalkyl)-λ 4 -tellanes with alcohols under unusually mild conditions.

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GeTe Nanosheets as Theranostic Agents for Multimodal Imaging and Therapy of Inflammatory Bowel Disease

Song

Yoon

Lee

et al. 2021

Adv Funct Materials

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Recently, 2D nanomaterials have received considerable attention in nanomedi cine due to their intrinsic optical properties, biocompatibility, and therapeutic effect. Here, 2D germanium telluride (GeTe) nanosheets coated with polyvinyl pyrrolidone (PVP) (GeTePVP NSs) developed as theranostic agents are reported that can be used for multispectral optoacoustic tomography (MSOT) and fluorescence imaging and therapy of inflammatory bowel disease (IBD). GeTePVP NSs, fabricated by simple sonication in ethanol and PVP, show broad optical absorption in visible and nearinfrared (NIR) ranges (400-1200 nm) and have intrinsic fluorescence properties. Thus, they provide deeper ex vivo and in vivo MSOT tissue images than gold nanorods or indocyanine green with strong optical absorption in the first NIR window (700-900 nm). In addition, when orally administered to IBD mice, GeTePVP NSs exhibit therapeutic efficacy similar to or higher than sulfasalazine, with strong accumulation at inflamma tory colon sites. This demonstrates that oral administration of GeTePVP NSs may be used to treat inflammatory diseases in the gastrointestinal tract.

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The effect of the novel tellurium compound AS101 on autoimmune diseases

Cited by 61 publications

References 79 publications

Crystallographic and docking (Cathepsins B, K, L and S) studies on bioactive halotelluroxetanes

Crystallographic and docking (Cathepsins B, K, L and S) studies on bioactive halotelluroxetanes

Highly efficient regioselective synthesis of organotellurium compounds based on the reactions of tellurium tetrachloride with 1-alkenes

GeTe Nanosheets as Theranostic Agents for Multimodal Imaging and Therapy of Inflammatory Bowel Disease

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