Resolution of Cox mediated inflammation by Se supplementation in mouse experimental model of colitis

Kaur, Ramanpreet; Thakur, Shivani; Rastogi, Pulkit; Kaushal, Naveen

doi:10.1371/journal.pone.0201356

Cited by 19 publications

(6 citation statements)

References 57 publications

(65 reference statements)

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“…It appears to be an effective, easy and inexpensive procedure ( 5 ); however, studies on the treatment of IBD have been limited to partial case reports and studies, and the specific mechanism of the anti-inflammatory effect remains elusive ( 6 ). A previous study that established an experimental UC model in mice with dextran sulfate sodium (DSS) revealed an intestinal flora disturbance similar to that observed in human IBD ( 7 ). The animal model of FMT is an invaluable complement to the clinical study of the efficacy of FMT due to the controllability of various variables.…”

Section: Introductionmentioning

confidence: 79%

Effect of fecal microbiota transplantation on experimental colitis in mice

Zhou

et al. 2019

Exp Ther Med

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The aim of the present study was to investigate the effect of fecal microbiota transplantation (FMT) on the acute inflammatory response in a murine model of dextran sulfate sodium (DSS)-induced colitis, and to delineate the putative underlying mechanism(s). Mice were divided into four groups, namely the normal control, DSS, 5-aminosalicylic acid (5-ASA) and FMT group. Mice in the DSS, 5-ASA and FMT groups were orally administered 3% DSS (w/v) solution for 7 days to induce colitis. On days 1, 3, 5 and 7, mice in the DSS, 5-ASA and FMT groups were respectively administered 0.5% carboxymethylcellulose sodium, 5-ASA suspension and fecal suspension by enema. The disease activity index of each mouse was calculated on a daily basis. All mice were sacrificed on day 8, and the length of their colons was measured. Myeloperoxidase (MPO) activity, and the levels of tumor necrosis factor α (TNF-α), interleukin (IL)-1β and IL-10 in the colon tissues of each group were also measured. Compared with that in the DSS group, FMT ameliorated the severity of inflammation due to ulcerative colitis in mice, which was accompanied by a significantly decreased MPO activity, reduced levels of TNF-α and IL-1β, and an increased level of IL-10 in colon tissue (all P<0.05). Taken together, these results demonstrated that FMT exerted a therapeutic effect on experimental colitis in mice, and the associated mechanism is likely to involve the remodeling of the intestinal flora and regulation of intestinal T-cell immunity homeostasis.

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Section: Introductionmentioning

confidence: 79%

Effect of fecal microbiota transplantation on experimental colitis in mice

Zhou

et al. 2019

Exp Ther Med

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“…Selenium supplementation in the context of IBD has not been documented in the literature outside of murine models. In these models, supplementation ameliorated cox-dependent inflammation by altering the PGE2 pathway [143,144]. Given the abundance of animal data, and the strong physiological link between selenium and immune function, the study of selenium therapy should be a future focus.…”

Section: Literature Reviewmentioning

confidence: 99%

Micronutrient Absorption and Related Outcomes in People with Inflammatory Bowel Disease: A Review

Kilby

Mathias

Boisvenue³

et al. 2019

Nutrients

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Inflammatory Bowel Disease (IBD) is a chronic disorder associated with immune dysregulation and chronic inflammation of the digestive tract. While it is poorly understood, the role of nutrition and nutrient status in the etiology of IBD and its associated outcomes has led to increased research relating to micronutrient deficiency. This review offers an overview of recent literature related to micronutrient absorption and outcomes in adults with IBD. Although the absorption and IBD-related outcomes of some micronutrients (e.g., vitamin D and iron) are well understood, other micronutrients (e.g., vitamin A) require further research. Increased research and clinician knowledge of the relationship between micronutrients and IBD may manifest in improved nutrient screening, monitoring, treatment, and outcomes for people living with IBD.

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“…However, the specific mechanisms by which the FMT protocol alleviates UC are still unclear, and most of what has been reported so far are partial case reports and studies. Although a recent study using a UC mouse model induced with dextran sulfate sodium (DSS) showed that the intestinal flora was similar to that of IBD in humans, more in vivo studies are needed to further validate previous claims [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation

Zhang

Zou

et al. 2020

J. Microbiol. Biotechnol.

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Inflammatory bowel disease (IBD) is an increasing global burden and a predisposing factor to colorectal cancer. Although a number of treatment options are available, the side effects could be considerable. Studies on fecal microbiota transplantation (FMT) as an IBD intervention protocol require further validation as the underlying mechanisms for its attenuating effects remain unclear. This study aims to demonstrate the ameliorative role of FMT in an ulcerative colitis (UC) model induced by dextran sulfate sodium (DSS) and elucidate its relative mechanisms in a mouse model. It was shown that FMT intervention decreased disease activity index (DAI) levels and increased the body weight, colon weight and colon length of experimental animals. It also alleviated histopathological changes, reduced key cytokine expression and oxidative status in the colon. A down-regulated expression level of genes associated with NF-κB signaling pathway was also observed. The results of 16S rRNA gene sequencing showed that FMT intervention restored the gut microbiota to the pattern of the control group by increasing the relative abundance of Firmicutes and decreasing the abundances of Bacteroidetes and Proteobacteria. The relative abundances of the genera Lactobacillus, Butyricicoccus, Lachnoclostridium, Olsenella and Odoribacter were upregulated but Helicobacter, Bacteroides and Clostridium were reduced after FMT administration. Furthermore, FMT administration elevated the concentrations of SCFAs in the colon. In conclusion, FMT intervention could be suitable for UC control, but further validations via clinical trials are recommended.

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Resolution of Cox mediated inflammation by Se supplementation in mouse experimental model of colitis

Cited by 19 publications

References 57 publications

Effect of fecal microbiota transplantation on experimental colitis in mice

Effect of fecal microbiota transplantation on experimental colitis in mice

Micronutrient Absorption and Related Outcomes in People with Inflammatory Bowel Disease: A Review

Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation

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