Resistin increases with obesity and atherosclerotic risk factors in patients with myocardial infarction

Association of Adiponectin, Resistin, and Vascular Inflammation

“…27 In men with acute myocardial infarction, a multivariate model revealed that obesity and C-reactive protein were independent variables associated with higher resistin levels. 28 Moreover, Weikert et al 29 reported that among 26 490 middle-aged subjects, individuals in the highest quartile of resistin level, compared with those in the lowest quartile of resistin level, had a significantly increased risk of myocardial infarction after adjustment for cardiovascular risk factors, including C-reactive protein (relative risk, 2.09; 95% confidence interval, 1.01 to 4.31). Recently, in 397 Korean patients with acute myocardial infarction, high resistin levels were predictors for all-cause mortality, independent of other risk factors.…”

Adipose Tissue as an Endocrine Organ: An Update on Pro-inflammatory and Anti-inflammatory Microenvironment

“…In humans, resistin is more expressed in preadipocytes during adipogenesis than in mature adipocytes, in which its expression is negligible (McTernan et al, 2002). Some authors documented that plasma resistin levels are elevated in obese humans (Piestrzeniewicz et al, 2008), whereas other authors reported that high insulin-sensitive athletes have higher plasma resistin levels than obese subjects (Perseghin et al, 2006). In this vein, it was observed that testosterone increases the expression of resistin (Fonseca-Alaniz et al, 2007).…”

Relationships between Serum Resistin and Fat Intake, Serum Lipid Concentrations and Adiposity in the General Population

“…Inflammasomes have been defined as intracytoplasmic, multiprotein "scaffolding" components in which the enzyme caspase-1 functions via IL-1 and IL-18 production 11) in the process of atherogenesis and the induction of insulin resistance and obesity 10,12) . However, the relationship between resistin and adipose tissue remains unclear; although the resistin levels are increased in obese patients with a history of myocardial infarction 13) , they are not decreased in obese patients who lose weight 14) . The evidence available to date regarding the relationship between resistin and adiposity in humans thus remains inconclusive 15) .…”