Resistin as potential biomarker for chronic periodontitis: A systematic review and meta-analysis

Akram, Zohaib; Rahim, Zubaidah Haji Abdul; Taiyeb-Ali, Tara B.; Shahdan, Mohd Shahril Amin; Baharuddin, Nor Adinar; Vaithilingam, Rathna Devi; Safii, Syarida Hasnur

doi:10.1016/j.archoralbio.2016.08.016

Cited by 44 publications

(31 citation statements)

References 36 publications

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“…The present study assessed bone loss around dental implants in relation to the metabolic parameter HbA1c, and the findings corroborate with other studies which demonstrated that chronic hyperglycemia may lead to changes in bone function [22, 23]. A possible explanation for increased crestal bone resorption may be explained by excessive proinflammatory responses through the expression of increased proinflammatory cytokines such as interleukin (IL)-6 and IL-1β, matrix metalloproteinase and tumor necrosis factor alpha in the gingival crevicular fluid and saliva in systemic diseases including T2DM patients [24, 25]. …”

Section: Discussionsupporting

confidence: 80%

Crestal Bone Loss Around Submerged and Non-Submerged Dental Implants in Individuals with Type-2 Diabetes Mellitus: A 7-Year Prospective Clinical Study

Zahrani

Mutairi

2018

Med Princ Pract

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Objective: In establishing an evidence-based rationale for the optimal use of implant therapy in patients with type 2 diabetes mellitus (T2DM), it is essential to first understand the impact of glycemic control on early healing and the success of dental implants. The objective of this study was to evaluate crestal bone loss (CBL) and stability around submerged and non-submerged dental implants in Saudi patients with well- and poorly controlled T2DM. Subject and Methods: Thirty-five patients with well-controlled T2DM (24 males and 11 females) and 32 poorly controlled T2DM patients (19 males and 13 females) were included. CBL was measured on digital radiographs; resonance frequency analysis (RFA) measurements were made for each implant at the time of fixture placement and at 3 months in both the groups. A p value less than 0.05 was considered statistically significant. Results: A total of 124 dental implants were placed. Mean RFA values between baseline and 3 months in poorly controlled T2DM patients was statistically significant (p = 0.048). CBL at first year (p = 0.047), second year (p = 0.041), third year (p = 0.046), and seventh year (p = 0.035) was significantly worse in poorly controlled T2DM. CBL around non-submerged dental implants showed statistically significant differences at all time-intervals (p < 0.05). Conclusion: Poorly controlled T2DM patients present worse peri-implant bone outcomes as compared to patients with well-controlled T2DM. We suggest that the predictability of successful dental implant therapy outcomes depends on the maintenance of optimal haemoglobin A1c levels.

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Section: Discussionsupporting

confidence: 80%

Crestal Bone Loss Around Submerged and Non-Submerged Dental Implants in Individuals with Type-2 Diabetes Mellitus: A 7-Year Prospective Clinical Study

Zahrani

Mutairi

2018

Med Princ Pract

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“…5 Substantial research in implant dentistry has led researchers to investigate several variations in implant therapy in terms of dental biomaterials, surface modifications, and various techniques. [15][16][17] Ample research on T2DM and clinical periodontal outcomes has been peformed, 18,19 Research suggests that poor glycemic control may demonstrate poor periodontal status and that periodontal therapy may have a significant effect on the glycemic status. 9,10 Nowadays, considerable research indicates that NDIs are also indicated in areas of narrow alveolar ridges, eluding complicated surgical interventions such as bone grafts and restoring geriatric patients with minimal invasive and cost-effective treatments.…”

Section: Introductionmentioning

confidence: 99%

Clinical and radiographic indices around narrow diameter implants placed in different glycemic‐level patients

Alsahhaf

Alshiddi

Alshagroud

et al. 2019

Clin Implant Dent Rel Res

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Background: Studies assessing peri-implant clinical and marginal bone resorption (MBR) around narrow diameter implants (NDIs) placed in different glycemic levels are uninvestigated. Objective: The present 3-year retrospective follow-up investigation was designed to explore clinical and radiographic status of NDIs placed in individuals with different glycemic control levels. Materials and Methods: Patients with serum hemoglobin A1c (HbA1c) levels ≥6.5% (Group-1), 5.7%-6.4% (Group-2), and 4.0%-5.0% (Group-3) were included. Clinical indices evaluating bleeding on probing (BOP), plaque scores (PI), peri-implant probing depth (PD), and MBR were recorded around NDIs at 1-, 2-, and 3-year follow-up. Serum HbA1c test was carried out for all patients to assess the profile of glycosylated hemoglobin at 1 and 3 years of follow-up. Results: A significant reduction in mean HbA1c levels from year 1 to year 3 followup period was seen in Group-1 only. PI varied from 0.40 in Group 1 at 2 year and 0.42 at 3-year follow-up to 0.18 at 2-year (P = 0.032) and 0.17 at 3-year (P = 0.018) follow-up, respectively. Greater BOP was noted in Group 1 (0.53) as compared with Group 2 (0.42) and Group 3 (0.21) (P = 0.048) at 3-year follow-up. PD after 3 year ranged from 2.04 mm in Group 3 to 2.32 mm in Group 1 that showed statistically significant difference (P = 0.037). No statistical significant differences were observed in MBR at any time point between the groups. Conclusion: The results of this short-term follow-up study indicate that NDIs show clinical and radiographic stability, provided oral cleanliness and glycemic levels are relatively maintained. Further long-term clinical studies are needed to evaluate implant stability over the period along with controlled glycemic status. K E Y W O R D S crestal bone levels, hyperglycemia, narrow implants, radiographs

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“…The possible pathological mechanisms involved in the peri-implant inflammation around dental implants can be explained by the increased systemic inflammatory burden in overweight subjects. [19][20][21] It should be noted that despite of patients being instructed on meticulous oral hygiene instructions at the time of implant surgery and at follow-ups, obese individuals showed increased values of PI and BOP. [19][20][21] It should be noted that despite of patients being instructed on meticulous oral hygiene instructions at the time of implant surgery and at follow-ups, obese individuals showed increased values of PI and BOP.…”

Section: Discussionmentioning

confidence: 99%

Comparison of clinical and radiographic peri‐implant parameters among obese and non‐obese patients: A 5‐year study

Alkhudhairy

Vohra

Al‐Kheraif

et al. 2018

Clin Implant Dent Rel Res

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Resistin as potential biomarker for chronic periodontitis: A systematic review and meta-analysis

Cited by 44 publications

References 36 publications

Crestal Bone Loss Around Submerged and Non-Submerged Dental Implants in Individuals with Type-2 Diabetes Mellitus: A 7-Year Prospective Clinical Study

Crestal Bone Loss Around Submerged and Non-Submerged Dental Implants in Individuals with Type-2 Diabetes Mellitus: A 7-Year Prospective Clinical Study

Clinical and radiographic indices around narrow diameter implants placed in different glycemic‐level patients

Comparison of clinical and radiographic peri‐implant parameters among obese and non‐obese patients: A 5‐year study

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