Resistant Starch Modified Cassava Flour (MOCAF) Improves Insulin Resistance

Firdaus, Jauhar; Sulistyani, Erma; Subagio, Achmad

doi:10.3923/ajcn.2018.32.36

Cited by 15 publications

(18 citation statements)

References 12 publications

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“…Starch is a high-molecular-weight plant-derived polysaccharide that consists of amylose and amylopectin and occurs in many crops, such as potato tubers, corn kernels, and cassava roots [1,2]. Starch is an affordable biologically renewable source of feedstock for the food, paper, pharmaceutical, and chemical industries [3][4][5]. Enzymes hydrolyze starch to its monomer glucose, which is an important and promising platform molecule employed in modern bioengineering [6].…”

Section: Introductionmentioning

confidence: 99%

Changes in the Crystallinity Degree of Starch Having Different Types of Crystal Structure after Mechanical Pretreatment

et al. 2020

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This paper examines the effect of mechanical activation on the amorphization of starch having different types of crystalline structure (A-type corn starch; B-type potato starch; and C-type tapioca starch). Structural properties of the starches were studied by X-ray diffraction analysis. Mechanical activation in a planetary ball mill reduces the degree of crystallinity in proportion to pretreatment duration. C-type tapioca starch was found to have the highest degree of crystallinity. Energy consumed to achieve complete amorphization of the starches having different types of crystalline structure was measured. The kinetic parameters of the process (the effective rate constants) were determined. The rate constant and the strongest decline in the crystallinity degree after mechanical activation change in the following series: C-type starch, A-type starch, and B-type starch.

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Section: Introductionmentioning

confidence: 99%

Changes in the Crystallinity Degree of Starch Having Different Types of Crystal Structure after Mechanical Pretreatment

et al. 2020

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“…The RS [18,19] and fiber [10] cannot be digested; then, it will be fermented by the microbiota in the intestine [18][19][20] and generated short-chain fatty acid (SCFA) [17,20]. SCFA can stimulate intestinal L cells which result in an increase on GLP-1 secretion of the cells [17,18].…”

Section: The Effects Of Ar On Glp-1 Serum Level In Diabetic Ratsmentioning

confidence: 99%

“…RS [20] and fiber [11] in the large intestine will be fermented by microbiota and produce SCFA [27,28]. Furthermore, SCFA stimulates GLP-1 secretion, hereafter, GLP-1 stimulates insulin secretion.…”

Section: The Effects Of Ar On Fbg Level In Diabetic Ratsmentioning

confidence: 99%

“…SCFA also has the effect of inhibiting activity of hormone-sensitive lipase in the blood [28] so that there was a decrease in lipolysis; furthermore, the free fatty acid (FFA) will decrease. Decreasing levels of FFA in the blood will increase insulin sensitivity [28] and reduce resistance to hexokinase enzyme activity; thereby, glycolysis and glycogenesis will increase so that the blood glucose levels decrease [20,27,29]. Because AR1 and AR1 contain high RS and fiber, it will be absorbed more slowly.…”

Section: The Effects Of Ar On Fbg Level In Diabetic Ratsmentioning

confidence: 99%

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Hypoglycemic Effect of High-Resistant Starch Analog Rice Through GLP-1 and Insulin or High-Resistant Starch Analog Rice Attenuates Blood Glucose Level Through Enhancement of GLP-1 and Insulin

Hairrudin

Soetjipto

Handajani

2019

Asian J Pharm Clin Res

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Objective: This study was to investigate the effect of analog rice (AR) on glucagon-like peptide-1 (GLP-1) and insulin serum levels, glucose transporter-2 (GLUT-2) expression, and fasting blood glucose (FBG) level in diabetic rats. Methods: Fifty male Wistar rats divided into the control group (n=10) and the experimental group. High-fat diet and streptozotocin were administered in experimental groups, which then divided into four equal groups (n=10, each) (negative control group, rice group, AR1 and AR2 group, given standard pellet, rice pellet, AR1 and AR2 pellet, respectively, for 6 weeks). GLP-1 and insulin serum levels were measured by enzyme-linked immunosorbent assay. The expression of GLUT-2 and the number of pancreatic β-cells observed using an immunohistochemistry method. Results: FBG levels in the AR1 and AR2 groups decreased, while the rice group remained. GLP-1 serum levels of the negative control and rice groups were not significantly different from the control group, while the AR1 and AR2 groups higher than the control group (p≤0.05). All the treatment groups had insulin serum levels significantly lower than control group (p≤0.05), except the AR1 group. The expression of GLUT-2 and the number of pancreatic β-cells in the treatment groups were less than the control group, but between treatment groups were not significantly different. Conclusion: AR significantly effective in reducing FBG level in diabetic rats through stimulation of increased GLP-1 and insulin serum levels serum levels but AR did not affect on the expression of GLUT-2.

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“…Penelitian yang dilakukan pada tikus membuktikan bahwa pemberian diet tinggi serat dapat meningkatkan short chain fatty acid (SCFA) atau asam lemak rantai pendek di usus besar dan di sirkulasi darah (12). Pemberian mocaf pada tikus terbukti dapat meningkatkan SCFA yang memiliki atom karbon kurang dari enam, meliputi asam asetat, asam propionat, dan asam butirat (13). Peningkatan SCFA tersebut berhubungan dengan aktifitas mikrobiota di usus besar (12,13).…”

Section: Pendahuluanunclassified

Efek kandungan serat beras analog terhadap ekspresi GLUT4 otot rangka tikus diabetes

Darajat

Sakinah

Hairrudin

2019

Jurnal Gizi Klinik Indonesia

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Effect of analog rice’s fiber on skeletal muscles GLUT4 expression in diabetic rats Background: Disruption of glucose transportation in skeletal muscle through GLUT4 becomes a problem in diabetes. Analog rice that had been modified by adding dietary fiber could improve the expression of GLUT4.Objective: This study aims to know the effect of dietary fiber toward GLUT4 expression and to know the dietary fiber percentage in analog rice.Method: The research type is true experimental with post-test only group design. The samples consist of 24 male Wistar rats that are group into 4 groups (n=6 each group). Three groups were induced by giving a high-fat diet for 40 days and streptozotocin (STZ) 35 mg/kg BW was given at 33th day and one group was not induced. After the blood glucose level exceeded 135 mg/dl, the treatment was given. After 3 weeks, the rats were terminated and quadriceps femoris muscle tissue was taken for immunohistochemistry examination using rat GLUT4 polyclonal antibody. GLUT4 expression was quantified using an immunoreactive score (IRS-GLUT4). The data were analyzed using the Kruskal-Wallis test and Spearman test.Results: Statistical analyses showed that there were significant differences between groups with a moderate positive correlation (correlation coefficient=0,651; p=0,003).Conclusion: Dietary fiber in analog rice could improve skeletal muscle GLUT4 expression in Wistar rat diabetic model.

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Resistant Starch Modified Cassava Flour (MOCAF) Improves Insulin Resistance

Cited by 15 publications

References 12 publications

Changes in the Crystallinity Degree of Starch Having Different Types of Crystal Structure after Mechanical Pretreatment

Changes in the Crystallinity Degree of Starch Having Different Types of Crystal Structure after Mechanical Pretreatment

Hypoglycemic Effect of High-Resistant Starch Analog Rice Through GLP-1 and Insulin or High-Resistant Starch Analog Rice Attenuates Blood Glucose Level Through Enhancement of GLP-1 and Insulin

Efek kandungan serat beras analog terhadap ekspresi GLUT4 otot rangka tikus diabetes

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