Resistant starch from green banana (Musa sp.) attenuates non-alcoholic fat liver accumulation and increases short-chain fatty acids production in high-fat diet-induced obesity in mice

Rosado, Carolyne Pimentel; Rosa, Victor Hugo Cordeiro; Martins, Bruna Cadete; Soares, Aruanna Cajaty; Santos, Izabelle Barcellos; Monteiro, Elisa Bernardes; Moura‐Nunes, Nathália; Costa, Cristiane Aguiar da; Mulder, Alessandra da Rocha Pinheiro; Daleprane, Julio Beltrame

doi:10.1016/j.ijbiomac.2019.09.199

Cited by 53 publications

(39 citation statements)

References 28 publications

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“…Some studies have showed that HFD up-regulated the expression or activity of FAS. 16,17 In our study, we observed that a HFD for 20 weeks led to an obvious lipid accumulation in liver, but the hepatic Fas was down-regulated and even DHA supplementation had no effect on its expression, which was in line with our in vitro data ( Figure 4A and B). This discrepancy might be attributed to compensatory response of hepG2 cells.…”

Section: Discussionsupporting

confidence: 89%

<p>DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model</p>

Luo

Sun

et al. 2020

DMSO

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Docosahexaenoic acid (DHA; C22; n-3) shows beneficial effects on Non-alcoholic fatty liver disease (NAFLD). Deacetylase Sirtuin1 (Sirt1) was reported to increase energy metabolism and decrease lipogenesis. Here, we investigated whether DHA plays a role in protecting against hepatic steatosis via Sirt1. Main Methods: Both in vivo and in vitro hepatic steatosis models were used: diet-induced obesity (DIO) model (middle-aged C57BL/6 mice fed a high-fat diet (HFD)) and palmitic acid (PA)-induced lipid accumulation cell model (HepG2 cells). Key Findings: In DIO mice, treatment with DHA (gavage supplementation) for 8 weeks not only inhibited the lipid accumulation, but also increased fatty acids (FA) oxidation and induced triglyceride export in liver. These changes were accompanied by attenuation of inflammation. Moreover, DHA reversed the HFD-induced reduction of Sirt1 in liver. Interestingly, the beneficial effects of DHA were reversed by lentivirus-mediated Sirt1 knockdown, accompanied with increased expression of markers of lipogenesis, inflammation and reduced FA oxidation. In HepG2 cells, DHA prevented the accumulation of PA-induced lipid droplets, the decrease of FA oxidation and the reduction of Sirt1 level. Inhibition of Sirt1 by sirtinol partially reversed the beneficial effects of DHA on PA-treated cells. Significance: DHA alleviated hepatic steatosis and reduced inflammation of liver in obese middle-aged mice by mechanisms involving Sirt1 activation.

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Section: Discussionsupporting

confidence: 89%

<p>DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model</p>

Luo

Sun

et al. 2020

DMSO

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“…SCFAs can enter the systemic circulation and activate AMPK in intestinal epithelial (28), skeletal muscle (29), and liver cells (30) either directly or indirectly. It is suggested that activation of AMPK through increased SCFA production is the main mechanism underlying the beneficial effects of a high-fiber diet on metabolic syndrome (31)(32)(33)(34). In agreement with previous studies (32-34), SDF treatment not only resulted in SCFA production but was also accompanied by the activation of AMPK in the liver (Figs.…”

Section: Discussionsupporting

confidence: 91%

Anti-diabetic effects of the soluble dietary fiber from tartary buckwheat bran in diabetic mice and their potential mechanisms

Wu¹,

Qin

et al. 2021

Food & Nutrition Research

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Background: Tartary buckwheat has beneficial effects on glucose and lipid metabolism of patients with type 2 diabetes mellitus. However, the physiological effects of a soluble dietary fiber (SDF) from tartary buckwheat have rarely been studied, especially in vivo. Objective: This study aimed to examine the hypoglycemic and hypolipidemic effects of SDF from tartary buckwheat bran on high-fat diet/streptozotocin-induced diabetic mice. Design: The SDF of tartary buckwheat bran was collected according to the Association of Official Analytical Chemists method 991.43. Diabetic mice were treated with high-fat diets supplemented with 0.5, 1, and 2% SDF for 8 weeks. Parameters related to glucose and lipid metabolism and relevant mechanisms, including the excretion of short-chain fatty acids and the glycemic signaling pathway in the liver, were investigated. In addition, the structural characterization of a purified polysaccharide from SDF of tartary buckwheat bran was illustrated. Result: Supplementation with SDF in the diet resulted in reduced levels of fasting blood glucose, improved oral glucose tolerance, increased levels of liver glycogen and insulin, as well as improved lipid profiles in both the serum and liver, in diabetic mice. The amelioration of glucose and lipid metabolism by SDF was accompanied by an increase in the short-chain fatty acid levels in the cecum and co-regulated by hepatic adenosine-5′-monophosphate-activated protein kinase (AMPK) phosphorylation. A neutral tartary buckwheat polysaccharide with an average molecular weight of 19.6 kDa was purified from the SDF, which consisted mainly of glucose with α-glycosidic bonds. Conclusions: The SDF of tartary buckwheat bran exhibits hypoglycemic and hypolipidemic effects in diabetic mice, contributing to the anti-diabetic mechanisms of tartary buckwheat.

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“…They also observed an almost 30% reduction in liver steatosis and 93% in triacylglycerol in the liver. Besides, they found the down regulation of AMPKp/AMPK (phosphorylated adenosine monophosphate activated protein kinase) and 3-hydroxy-3-methylglutaryl-coenzyme a reductase that is related to the regulation of lipids in the liver (Rosado et al, 2020;Silva et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, fibers can decrease the appetite both in obese and non-obese subjects. For these reasons, these dietetic compounds are associated with the reduction of obesity, diabetes, and cardiovascular complications (Fornari et al, 2020;Rosado et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Metabolic profile of wistar rats after consumption of flour prepared with grains and fruits

Bucalem¹,

Amaro²,

Prado³

et al. 2021

J. Med. Plants Res.

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The occurrence of chronic and degenerative diseases, such as obesity, diabetes, cardiovascular disease (CVD), and cancer is increasing sharply. In the last years, there has been an increase in interest in the consumption of foods with functional properties that are related to weight loss and disease prevention. For these reasons, this study aimed to evaluate the effects of flour prepared with grains and fruits on the metabolic profile of Wistar rats. Female rats were randomly divided into four groups: G1: control group; G2: Animals that received condensed milk and sugar; G3: Animals that received food supplemented with a mixture of powdered grains and fruits; G4: Animals that received condensed milk, sugar and rat food supplemented with a mixture of powdered grains and fruits. The authors results showed that the use of the flour of grains and fruits promoted a significant reduction in abdominal circumference, visceral fat, and triglycerides levels in the animals from G3 compared with G1. However, the use of the flour of grains and fruits can be beneficial in association with a balanced diet. When the association is carried out at the same time that there is the consumption of foods rich in sugars, the beneficial effects was not observed.

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Resistant starch from green banana (Musa sp.) attenuates non-alcoholic fat liver accumulation and increases short-chain fatty acids production in high-fat diet-induced obesity in mice

Cited by 53 publications

References 28 publications

<p>DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model</p>

<p>DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model</p>

Anti-diabetic effects of the soluble dietary fiber from tartary buckwheat bran in diabetic mice and their potential mechanisms

Metabolic profile of wistar rats after consumption of flour prepared with grains and fruits

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