Resistance to infection in the alloxan‐diabetic rabbit

Ah, Cruickshank

doi:10.1002/path.1700670205

Cited by 25 publications

(9 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Upon completion of the experiment, we noted that histopathological as well as the immunofluorescence and ultrastructural studies showed more prominent pathological changes with earlier onset of the features. Experimental models of infections in rabbits, rats, and mice with chemically induced diabetes have shown increased susceptibility to various bacterial and fungal infections [3,[5][6][7]. Some studies to the contrary have shown no increased susceptibility to infection [8].…”

Section: Discussionmentioning

confidence: 99%

“…Classically, APIGN develops following streptococcal upper respiratory tract or skin infections [1,2]. More recently, other organisms, particularly Staphylococcus and Gram-negative bacteria, have been linked to APIGN in adults and elderly patients [3][4][5]. In the developed countries, Staphylococcus has become three times more common than Streptococcus as the responsible infectious agent for APIGN in the elderly population [3].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Diabetes on Acute Post-Infectious Glomerulonephritis in Rats: An Experimental Study with Literature Review

Kfoury¹,

Alsuwaida²,

Alghonaim³

et al. 2017

J Clin Exp Nephrol

View full text Add to dashboard Cite

Background: The concurrence of diabetes and nephritogenic infections may have a tremendous impact on the kidney. The approach to the two concurrent diseases is based on histological, immunofluorescence findings and most importantly on ultrastructural features. In this experiment our aim was to compare the pattern of injury seen in the kidney in animals with induced post-infectious glomerulonephritis with and without associated diabetes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Impact of Diabetes on Acute Post-Infectious Glomerulonephritis in Rats: An Experimental Study with Literature Review

Kfoury¹,

Alsuwaida²,

Alghonaim³

et al. 2017

J Clin Exp Nephrol

View full text Add to dashboard Cite

show abstract

“…In in vivo studies, diabetic animals have shown an increased susceptibility to bacterial infections due to various impaired host defense mechanisms (4,7,13). Same researchers reported, in contrast, that diabetic animals did not always have increased susceptibility to bacterial infections (3,8). The discrepancy in these studies may be caused by using different animal models in each of the experiments.…”

mentioning

confidence: 99%

Bacterial Translocation from the Gastrointestinal Tract in Various Mouse Models for Human Diabetes

Ohsugi

Maejima

Urano

1991

Microbiology and Immunology

View full text Add to dashboard Cite

Bacterial translocation from the gastrointestinal (GI) tract to other internal organs was examined in multiple low-dose streptozotocin-injected (M-STZ), single large-dose streptozotocin-injected (S-STZ), alloxan-injected (Alloxan), and non-obese diabetic (NOD) mice. The incidence of bacterial translocation from the GI tract to the tested organs among diabetic mice was in the order of M-STZ mice> S-STZ mice>NOD, Alloxan, and control mice. The injections of insulin to M-STZ mice did not decrease the incidence of translocation.These results suggest that bacterial translocation from the GI tract in diabetic mice is not induced by diabetes.

show abstract

“…In most experiments only a few cells were noted to be sticking to vascular endothelium within 9 to 12 hr (Fig. 5), and no sticking was to be found in a few chambers by 12 lhr. In other experiments very light sticking of white blood cells was observed during the entire 24 hr of stud,.…”

Section: Chronic Experimentsmentioning

confidence: 90%

“…It is remarkable that no systematic effort has been made, to the best of the authors' knowledge, to determine in vivo whether the osmolality attending hyperglycemia in itself will modify the exudative aspects of acute inflammation in extrarenal loci. There is evidence, however, that hyperglycemia complicated by ketoacidosis in uncontrolled diabetes mellitus is associated with an impaired inflammatory reaction (3)(4)(5)12).…”

Section: Introductionmentioning

confidence: 99%

Studies on the pathogenesis of acute inflammation

Ainsworth¹,

Allison²

1970

J. Clin. Invest.

View full text Add to dashboard Cite

A B STR A CT The inflammatory reaction induced in ear chambers of rabbits by heat injury was studied in nondiabetic animals made hyperglycemic with continuous infusions of glucose. Hypertonic solutions of glucose administered intravenously to rabbits induced the following triad: hyperglycemia, hyperosmolality, and metabolic lactic acidosis. It was found that relatively short periods of this metabolic abnormality were associated with a significant reduction in the intensity of the inflammatory reaction.There was no evidence microscopically of circulatory impairment within ear chambers; and since neither arterial hypotension nor oxygen deficit was recorded during experiments, it appeared most likely that decreased leucocytic margination per se best explained the inhibited exudative response.Hyperglycemia seemed the dominant factor responsible for this anti-inflammatory effect. It was found subsequently that hyperglycemia and hyperosmolality without metabolic acidosis impaired cellular exudation just as well.

show abstract

Resistance to infection in the alloxan‐diabetic rabbit

Cited by 25 publications

References 16 publications

The Impact of Diabetes on Acute Post-Infectious Glomerulonephritis in Rats: An Experimental Study with Literature Review

The Impact of Diabetes on Acute Post-Infectious Glomerulonephritis in Rats: An Experimental Study with Literature Review

Bacterial Translocation from the Gastrointestinal Tract in Various Mouse Models for Human Diabetes

Studies on the pathogenesis of acute inflammation

Contact Info

Product

Resources

About