The Impact of Diabetes on Acute Post-Infectious Glomerulonephritis in Rats: An Experimental Study with Literature Review

Kfoury, Hala; Alsuwaida, Abdulkareem; Alghonaim, Mohammed; Husain, Sufia; Aljuhani, Tariq; Hagar, Hanan; Moussa, Safia; Ginawi, Ibrahim Abdelmajeed

doi:10.21767/2472-5056.100050

Cited by 1 publication

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kfoury et al postulated that dysglycemia is associated with more aggressive histological lesions of IRGN based on animal studies 34 . However, we did not observe any difference in renal histology nor outcomes in patients with and without dysglycemia at presentation.…”

Section: Discussioncontrasting

confidence: 77%

See 1 more Smart Citation

Bacterial infection‐related glomerulonephritis in patients with diabetes

et al. 2023

View full text Add to dashboard Cite

AimDiabetic patients are prone to infections, thus making them a unique cohort at risk of developing bacterial infection‐related glomerulonephritis (IRGN).MethodsIn total, 1693 adult diabetic patients underwent kidney biopsy between 2005 and 2021 at our tertiary care hospital in South India. Of these, 121 consecutive cases which met criteria of bacterial IRGN were included in this study.ResultsThe mean age of the cohort was 53.1 ± 10.1 years and 83/121 (68.5%) were males. Majority (98.3%) had type 2 diabetes for a median duration of 6 (IQR, 2–12) years. The most common sites of infection were skin (47/121, 38.8%) and urinary tract (15/121, 12.4%). Fifty percent (58/121) of patients had underlying advanced diabetic kidney disease (DKD). Isolated C3 deposits (without immunoglobulin) occurred in 66/121 (54.5%) patients predominantly in advanced DKD patients. IgA‐dominant glomerulonephritis occurred in only 9/121 (7.4%) patients. Short‐course oral steroid was given to 86/121 (71.1%) patients. Steroid related dysglycemia and immunosuppression related infections occurred in 9/61 (14.8%) and 16/61 (26.2%) patients respectively. Of the 90 patients with follow up details >3 months, 46 (51.1%) progressed to kidney failure over a median period of 0.5 (IQR, 0–7.2) months. Patients diagnosed in the latter half of our study period (2013–2021) were older, less commonly presented with fever, had more pronounced hypocomplementemia and severe renal histology predominantly with a ‘starry sky’ immunofluorescence pattern.ConclusionSuperimposed bacterial IRGN on underlying DKD is associated with poor renal outcomes. Use of short course steroid was associated with significant toxicity.

show abstract

Section: Discussioncontrasting

confidence: 77%

“…34 However, we did not observe any difference in renal histology nor outcomes in patients with and without dysglycemia at presentation. Nasr et al reported IgA-dominant IRGN as the predominant histopathological pattern in diabetic patients (50%-75%) 32.…”

contrasting

confidence: 63%