Resistance to Erythromycin and Telithromycin in
            <i>Streptococcus pyogenes</i>
            Isolates Obtained between 1999 and 2002 from Greek Children with Tonsillopharyngitis: Phenotypic and Genotypic Analysis

Grivea, Ioanna N.; Al‐Lahham, Adnan; Katopodis, George D.; Syrogiannopoulos, George A.; Reinert, Ralf René

doi:10.1128/aac.50.1.256-261.2006

Cited by 51 publications

(45 citation statements)

References 23 publications

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“…28 Telithromycin resistance has particularly been reported in erm(B)-positive (cMLS) S. pyogenes isolates, although telithromycin retained activity against strains possessing the other macrolide resistance genotypes, such as erm(A) and mef(A). 17,20,30 This explains the full susceptibility to telithromycin in all of the isolates we studied, in which erythromycin resistance was due to erm(TR).…”

Section: Discussionmentioning

confidence: 99%

Macrolide and Tetracycline Resistance andemmType Distribution ofStreptococcus pyogenesIsolates Recovered from Turkish Patients

Dündar

Sayan

Tamer

2010

Microbial Drug Resistance

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The aims of this study were to determine the susceptibilities to macrolide and tetracycline antibiotics and emm type distribution of Streptococcus pyogenes strains isolated in the Kocaeli University Hospital, Turkey. A total of 127 S. pyogenes clinical isolates were tested. Eleven (9%) isolates were resistant to erythromycin, and 23 (18%) isolates were resistant to tetracycline. Ten of the erythromycin-resistant isolates were also resistant to tetracycline. By the triple-disk test, all erythromycin-resistant isolates showed the inducible macrolide-lincosamidestreptogramin-C phenotype and harbored erm(TR) gene. tet(O) was the most common tetracycline resistance gene. Among erythromycin-tetracycline coresistant isolates, seven harbored the tet(O) gene. emm 4, emm 1, emm 2,114, and emm 89 were the most common emm types. These isolates were more susceptible to erythromycin. There was considerable emm type heterogeneity in macrolide or tetracycline resistant isolates. According to our knowledge, this is the first study in which emm type distribution is investigated in Turkey. More comprehensive studies are needed to obtain true information about the epidemiology of macrolide and tetracycline resistance and emm type distribution in Turkey.

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Section: Discussionmentioning

confidence: 99%

Macrolide and Tetracycline Resistance andemmType Distribution ofStreptococcus pyogenesIsolates Recovered from Turkish Patients

Dündar

Sayan

Tamer

2010

Microbial Drug Resistance

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“…GAS resistance to macrolides is increasing in many countries, ranging from 6.2% in North America to more than 20% in some European countries [4]. However, great variability across different areas has been reported [5] and scarce data are available for GAS isolated in South America [6][7][8][9]. GAS tetracycline resistance is also reported in many countries and data from South America show a proportion of resistant isolates ranging from 8 to 70% [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Polyclonal dissemination of tetracycline resistance among Streptococcus pyogenes paediatric isolates from Brazil

Smeesters

Cadar

Dreze

et al. 2010

J Infect Dev Ctries

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Introduction: Scarce data are available on Group A Streptococcus (GAS) antibiotic resistance in South America. Methodology: The antibiotic susceptibility patterns of GAS recovered from symptomatic children living in the central part of Brazil during a prospective epidemiological study were analyzed. Results: No isolates were resistant to penicillin or macrolides. Sixty-one percent of the isolates were highly resistant to tetracycline, of which 85% harboured the tetM resistance gene. Ninety-five percent of these tetracycline resistant isolates were also resistant to minocycline. Thirty different emm-types were associated with tetracycline resistance. Phylogenetic analysis indicates that tetracycline resistance arose independently in distantly related emm-types. Conclusions: A high level of GAS tetracycline resistance has been observed in the central part of Brazil due to the polyclonal dissemination of resistant emm-types.

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“…The distribution of emm genotypes during a defined period can be used to understand the dynamic changes in GAS strains in the region. Several reports have been published on the correlation between emm genotypes and antibiotic resistance, but the distributions of antibiotic-resistant emm genotypes vary geographically [13,14]. In general, antibiotic resistance is closely associated with the consumption of drugs.…”

Section: Introductionmentioning

confidence: 99%

Decline in Erythromycin Resistance in Group A Streptococci from Acute Pharyngitis due to Changes in theemmGenotypes Rather Than Restriction of Antibiotic Use

Koh

Kim

2010

Ann Lab Med

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Resistance to Erythromycin and Telithromycin in Streptococcus pyogenes Isolates Obtained between 1999 and 2002 from Greek Children with Tonsillopharyngitis: Phenotypic and Genotypic Analysis

Cited by 51 publications

References 23 publications

Macrolide and Tetracycline Resistance andemmType Distribution ofStreptococcus pyogenesIsolates Recovered from Turkish Patients

Macrolide and Tetracycline Resistance andemmType Distribution ofStreptococcus pyogenesIsolates Recovered from Turkish Patients

Polyclonal dissemination of tetracycline resistance among Streptococcus pyogenes paediatric isolates from Brazil

Decline in Erythromycin Resistance in Group A Streptococci from Acute Pharyngitis due to Changes in theemmGenotypes Rather Than Restriction of Antibiotic Use

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