Résistance plasmidique aux quinolones

Evolution of Resistance to Fluoroquinolones of Uropathogenic Strains of <i></i>Escherichia coli Isolated at the University Hospital of Marrakesh, Morocco

“…The acquired resistance to these antibiotics is the result of the combination of several mechanisms: The mechanisms of resistance most frequently found are related to impermeability of the bacterial wall by reducing the expression or inactivation of the gene coding for porins. Chromosomal point mutations in antibiotic targets, gyrase (encoded by gyrA / B genes) and topoisomerase IV (parC / E gene), or the acquisition or over expression of an efflux pump reducing concentration of fluoroquinolones in bacteria [20].…”