Antimicrobial susceptibility of urinary Klebsiella pneumoniae and the emergence of carbapenem-resistant strains: A retrospective study from a university hospital in Morocco, North Africa

Bouamri, M.C. El; Arsalane, Lamiae; Kamouni, Youssef El; Zouhair, Said

doi:10.1016/j.afju.2014.10.004

Cited by 44 publications

(41 citation statements)

References 27 publications

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“…than non-ESBL producing Klebsiella spp (Schwaber et al, 2006;Kim et al, 2002). ESBL producing Klebsiella pneumoniae isolated were 17.5% almost the same results were obtained in the other studies (Romero et al, 2007;El Bouamri et al, 2015). This study shows that 91.2% of isolates were susceptible to Imipenem.…”

Section: Resultssupporting

confidence: 78%

A Study on Prevalence and Antimicrobial Resistance Pattern of Urinary Klebsiella pneumoniae in a Tertiary Care Centre in South India

Vedachalam¹,

Suresh²

2018

Int.J.Curr.Microbiol.App.Sci

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Section: Resultssupporting

confidence: 78%

A Study on Prevalence and Antimicrobial Resistance Pattern of Urinary Klebsiella pneumoniae in a Tertiary Care Centre in South India

Vedachalam¹,

Suresh²

2018

Int.J.Curr.Microbiol.App.Sci

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“…Levofoxacin after culture sensitivity testing. Study performed by Bouamri et al also shows similar results 18. …”

supporting

confidence: 64%

Antibiotic sensitivity profile of Klebsiella isolates and it’s impact on clinical outcome

Damor

Kubavat

2019

Int J Basic Clin Pharmacol

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Background: Antimicrobials are the greatest discovery of the twentieth century. To limit the emergence and spread of resistance, antibiotic therapy should be adjusted according to the results of microbiological culture. Klebsiella isolates causes various types of infections and the incidence of antibiotic resistance is also high in Klebsiella infections. So, Authors plan this study to analyze how the results of microbiological cultures influence the antibiotic use in the treatment of Klebsiella infections.Methods: It is a record based observational prospective study which assessed the impact of Klebsiella positive culture results on antibiotic prescribing pattern and its impact on clinical outcome. Patients with empirical antibiotic therapy and Klebsiella positive were included and patients with inadequate data were excluded in this study and the data were recorded. Recorded data were entered and analyzed in Microsoft Office Excel-2013. Unpaired student t-test was used to compare the mean duration of hospital stay using Past software (version 3.20).Results: There were total 400 patients in our study. Amikacin was the most common drug (n=202) used as empirical therapy. Empirical antibiotic therapy was changed in 161(40.25%) patients. Meropenem was the most commonly used definitive drug. Mean duration of hospital stay is less in empirical sensitive antibiotic therapy as compared to empirical resistance antibiotic therapy having p value <0.0001 which shows significant difference between two groups showing better clinical outcome.Conclusion: Initial empirical therapy with broad-spectrum antimicrobials is a treatment strategy for severe Klebsiella infections.

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“…22 Nitrofurantoin has remained successful after many decades of extensive use worldwide with very low resistance rate. 76 Nitrofurantoin ESBL production (24%)…”

Section: Acute Reactionmentioning

confidence: 99%

Role of Nitrofurantoin in the Management of Urinary Tract Infection - A Systematic Review

Alam¹,

Rana²,

Bhardwaj³

et al. 2019

jemds

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BACKGROUND Urinary tract infections are often caused by bacteria resistant to antibiotics which have evolved to be a major health issue in recent years. Often, urinary tract infections are very hard to treat and if not appropriately treated in time, may result in serious consequences, particularly, when it spreads to kidneys ultimately resulting in an increase in morbidity and mortality. Nitrofurantoin, a first line agent and has bactericidal action, frequently used to treat uncomplicated urinary tract infection. The literature was searched with published sources from Medline, PubMed and Embase search engines. Published articles were searched, of which 81 articles were eligible to be included for this systematic review. Nitrofurantoin is reduced by the action of bacterial flavoproteins to reactive intermediate compounds that non-specifically inactivate ribosomal proteins resulting in inhibition of protein synthesis. Various mechanisms seem to be responsible for the reduced capability of microorganism to acquire resistance in a faster manner. Nitrofurantoin exhibits high quality success against most bacteria anticipated in urinary tract infection. Nitrofurantoin has been recommended for prophylaxis in the treatment of reinfection in case of recurrent uncomplicated urinary tract infections in many western countries. Nitrofurantoin is one of the treatment options for urinary tract infection due to extended spectrum beta lactamase producing Escherichia coli. In pregnant women with urinary tract infection, nitrofurantoin can be appropriate treatment. Also, nitrofurantoin associated reactions have been reported in many studies. This review updates the clinical use of nitrofurantoin, including new facts about the role of nitrofurantoin in the therapy of community acquired urinary tract infection, adverse outcomes, complications, interactions and antibiotic resistance mechanism against different uropathogens.

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Antimicrobial susceptibility of urinary Klebsiella pneumoniae and the emergence of carbapenem-resistant strains: A retrospective study from a university hospital in Morocco, North Africa

Cited by 44 publications

References 27 publications

A Study on Prevalence and Antimicrobial Resistance Pattern of Urinary Klebsiella pneumoniae in a Tertiary Care Centre in South India

A Study on Prevalence and Antimicrobial Resistance Pattern of Urinary Klebsiella pneumoniae in a Tertiary Care Centre in South India

Antibiotic sensitivity profile of Klebsiella isolates and it’s impact on clinical outcome

Role of Nitrofurantoin in the Management of Urinary Tract Infection - A Systematic Review

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