Resistance of Salmonellae Isolated in 1959 and 1960 to Tetracyclines and Chloramphenicol

Ramsey, Carolyn H.; Edwards, P. R.

doi:10.1128/aem.9.5.389-391.1961

Cited by 18 publications

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References 6 publications

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“…The clinical problem posed by bacterial resistance to penicillin and streptomycin has led to intensive research into the mechanism of resistance to these drugs. Bacterial resistance to the tetracycline antibiotics has not generally been common, but recent evidence (Ramsey & Edwards, 1961) suggests that it may now be an increasing problem with a need for closer investigation of the mechanism of resistance to these drugs. Studies on resistance to the tetracyclines have been hindered by inadequate knowledge of the mode of their antibiotic action.…”

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confidence: 99%

RESISTANCE OF ESCHERICHIA COLI TO TETRACYCLINES

Franklin¹,

Godfrey²

1965

Biochemical Journal

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1. A strain of Escherichia coli highly resistant to chlortetracycline and partially cross-resistant to tetracycline has been isolated. 2. The nitro-reductase system of the resistant cells was inhibited to a smaller extent by chlortetracycline than was the corresponding enzyme of sensitive cells. 3. The incorporation of leucine in vitro into the ribosomal protein of cell-free preparations from sensitive and resistant cells was equally inhibited by chlortetracycline. 4. Resistant cells accumulated much less chlortetracycline and tetracycline than did sensitive cells when both were cultured in the presence of these drugs. 5. The uptake of tetracycline by both sensitive and resistant E. coli was dependent on the presence of glucose in the medium. 6. Fractionation of cells cultured in medium containing [(14)C]chlortetracycline indicated that the largest proportion of radioactivity in sensitive cells was in the fraction consisting mainly of cell-wall material. There was no concentration of radioactivity in any one fraction of the resistant cells. 7. No evidence could be obtained for a specific tetracycline-excretion system in the resistant cells. 8. The significance of these results in relation to current theories of the antibiotic action of and resistance to the tetracycline drugs is discussed.

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RESISTANCE OF ESCHERICHIA COLI TO TETRACYCLINES

Franklin¹,

Godfrey²

1965

Biochemical Journal

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“…The investigations of Ramsey & Edwards (1961) show that over the years from 1948 to 1960 there was a gradual increase from 0 to 29-0 % in the resistance of S. typhimurium to tetracycline. Manten, Kampelmacher & Guinee (1964) found a similar increase of from 2-1 % in 1959 to 24-4 % in 1962.…”

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confidence: 99%

Salmonellae and shigellae in a group of urban South African Bantu school children

Richardson

Koornhof

Hayden-Smith

1966

J. Hyg.

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1. Faeces from apparently healthy Bantu children from schools in Soweto township near Johannesburg were examined eight times at fairly regular intervals over a period of 1 year.2. Only fifty-five children were present for all eight investigations and, of these, 36·4% yielded salmonellae and 9·1% shigellae. Taking the group as a whole, 26·2% of the children had salmonella infections and 6·2% shigella infections.3. Parasites were shown to be present in sixty-four of the 130 children during the period of the investigation.4. As in other surveys, there were more isolations in summer than in winter.5.S. labadiandS. typhimuriumwere most frequently isolated, with the group B–E constituting 75% of the total isolations.S. typhi, S. paratyphi A, BandCwere not found.6. Water supplied to each house by the Johannesburg municipality was of good quality, yet it did not affect the incidence of salmonellosis and shigellosis.7. In spite of better socio-economic conditions the incidence of salmonellosis is comparable to the two previously mentioned surveys. These findings indicate a lack of instruction on personal hygiene and the importance of public health measures.

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“…Les premières études crédibles sur les salmonelles non-typhiques, c'est-à-dire avec une méthodologie fiable et avec des souches représentatives, datent de la fin des années 1940 aux États-Unis. Ces études menées de 1948 à 1962 par l'ancêtre des Centers for Disease Control (CDC) d'Atlanta sur des souches collectées dans tout le pays ne testaient que deux antibiotiques, les cyclines et le chloramphénicol (C) (tableau 1) (Ramsey & Edwards, 1961;McWhorter et al 1963). Les études de 1948 et 1956-1957 n'analysaient que le sérotype majoritaire, Typhimurium.…”

Section: Données Internationales (à L'exception De La France)unclassified

“…Une étude néerlandaise révélait que les souches de sérotype Typhimurium d'origine humaine (60 % de l'ensemble des souches de Salmonella) ou d'origine porcine (80 % de l'ensemble des souches de Salmonella) étaient sensibles à la Te en 1960 mais étaient devenues résistantes à 80 % en 1974 (Van Leeuwen et al1979 Ramsey & Edwards, 1961 ;McWhorter et al 1963 ;Schroeder et al 1968 ;Ryder et al 1980 ;Riley et al 1984 ;MacDonald et al 1987). (Glynn et al 1998).…”

Section: Données Internationales (à L'exception De La France)unclassified

Salmonelles non-typhiques d'origine animale et résistance aux antibiotiques

Weill¹

2008

bavf

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Le genre Salmonella est divisé en deux espèces (S. enterica et S. bongori). L'espèce S. enterica est elle-même subdivisée en six sous-espèces. Ces différents taxons sont ensuite subdivisés en plus de 2500 sérotypes. En France, le nombre de cas confirmés de salmonellose chez l'homme entre 1995 et 1999 a été estimé entre 32000 et 43000 par an, avec 6000 à 10700 hospitalisations et 100 à 560 décès. Deux sérotypes Enteritidis et Typhimurium sont ultra-prédominants dans notre pays. Ils représentent environ 70 % de tous les isolements de Salmonella chez l'homme. Parallèlement à ce qui se passe dans la plupart des pays développés, en France, le nombre d'isolats humains de salmonelles non-typhiques multirésistantes aux antibiotiques et en particulier, aux céphalosporines de 3 e génération et aux quinolones, n'a cessé de croître depuis ces cinq dernières années. La sélection de telles souches est souvent consécutive à l'utilisation de ces familles d'antibiotiques chez l'animal. Mots-clés : Salmonella, résistance aux antibiotiques. RÉSUMÉ The Salmonella genus is divided into two species : enterica and bongori. S. enterica itself is subdivided into six subspecies. These different taxons represent over 2,500 serotypes. In France, the number of salmonellosis cases confirmed between 1995 and 1999 is estimated between 32 000 and 43,000 per annum, with 6,000 to 10,700 hospitalisations (and 100 to 560 deaths). Two serotypes are ultra predominant in our country : Typhimurium and Enteritidis. They represent about 70 % of all Salmonella strains isolated in man each year. As observed in most developed countries, the number of non-typhoïdal Salmonella strains isolated in humans in France, multiresistant to antibiotics, and in particular to 3rd generation cephalosporins and quinolones, has been rising steadily over the past five years. The selection of such strains is often due to the use of these classes of antibiotics on animals.

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Resistance of Salmonellae Isolated in 1959 and 1960 to Tetracyclines and Chloramphenicol

Cited by 18 publications

References 6 publications

RESISTANCE OF ESCHERICHIA COLI TO TETRACYCLINES

RESISTANCE OF ESCHERICHIA COLI TO TETRACYCLINES

Salmonellae and shigellae in a group of urban South African Bantu school children

Salmonelles non-typhiques d'origine animale et résistance aux antibiotiques

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