In this paper, we report a novel approach to fabricate a low cost, large area and flexible mould and its applications in large area roller embossing. A liquid crystal polymer (LCP) film, which had a high glass transition temperature of 280°C, was clad with copper foils on both sides, was used as a starting material for mould fabrication. The LCP film and the copper foils were 50 and 36 lm thick, respectively. The LCP-Cu flexible mould was obtained through photolithographic patterning and wet etching of the copper foil on top surface of the LCP film. Using this proposed method, a polymer-metal hybrid flexible mould with an area of 150 mm 9 150 mm was fabricated. The fabricated mould has a minimum feature size of 25 lm, and has been successfully used to demonstrate large area micro roller embossing. Micro channels, micro dots and micro mixers were embossed on polymeric as well as ceramic green substrates.