Resin Hemoperfusion for Unconjugated Bilirubin Removal

Sideman, S.; Mor, L.; Mihich, M; Mordohovich, D.; Lupovich, S; Brandes, Joseph M.; Zeltzer, M.

doi:10.1159/000406181

Cited by 24 publications

(26 citation statements)

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“…33 Sideman et al reported bilirubin-adsorption capacities between 2 and 24 mg/ leased from the albumin conjugates to attain this equilibrium, which, we believe, was also the case g with a macroreticular resin. 12 Kanai et al developed an improved model of an anion-exchange in our system. This process will continuously strip bilirubin molecules from the protein conjugate unresin and they obtained a maximum amount of bilirubin of 7.7 mg/g.…”

Section: Resultsmentioning

confidence: 99%

“…Large concentrapatients suffering from hyperbilirubinemia by hetions of bilirubin in the blood have, therefore, been moperfusion treatment, that is, the circulation of associated with hepatic failure and with neurologblood through an extracorporeal unit containing ical brain damage of newborn babies suffering an adsorbent system for bilirubin. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Albuminfrom hemolysing diseases. 1 Bilirubin is a yellowimmobilized agarose, 4 activated charcoal, 5 and agar 6 have been used as sorbents in hemoperfusion columns.…”

Section: Introductionmentioning

confidence: 99%

“…Toluene (Merck AG, Darnewborn babies using albumin-deposited macromstadt, Germany) was utilized as the diluent and reticular resin. 12 Brown prepared oligopeptideused as received. The dispersion medium was disfunctionalized polyacrylamide beads as an affinity tilled water.…”

Section: Introductionmentioning

confidence: 99%

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Specific sorbents for bilirubin removal from human plasma: Congo red-modified poly(EGDMA/HEMA) microbeads

Denizli¹,

Kocakulak²,

Pi̇şki̇n³

1998

J. Appl. Polym. Sci.

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Congo Red-modified poly(EGDMA-HEMA) microbeads were investigated as a specific sorbent for bilirubin removal from human plasma. Poly(EGDMA-HEMA) microbeads were prepared by a modified suspension copolymerization technique. Congo Red was covalently incorporated into the poly(EGDMA-HEMA) microbeads via condensation reactions between the aromatic amine groups of the dyes and the hydroxyl groups of the HEMA, under alkaline conditions. Bilirubin adsorption was investigated from hyperbilirubinemic human plasma on the poly(EGDMA-HEMA) microbeads containing different amounts of attached Congo Red (between 2.5 and 14.6 mmol/g). The nonspecific bilirubin adsorption on the unmodified poly(EGDMA-HEMA) microbeads were 0.32 mg/g from human plasma. High adsorption rates were observed at the beginning, and the adsorption equilibrium was then gradually achieved in about 30-60 min. Much higher bilirubin adsorption values, up to 11.7 mg/g, were obtained with the Congo Red-modified microbeads especially at 37ЊC. The numbers (as mmol) of bilirubin molecules to albumin molecules adsorbed on the sorbent microbeads were in the range of 15-20, which showed that bilirubin molecules were preferentially adsorbed to the Congo Red-modified microbeads. Bilirubin adsorption increased with increasing temperature.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Specific sorbents for bilirubin removal from human plasma: Congo red-modified poly(EGDMA/HEMA) microbeads

Denizli¹,

Kocakulak²,

Pi̇şki̇n³

1998

J. Appl. Polym. Sci.

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“…The adsorbents should naturally have high adsorption capacity, good bio compatibility and blood compatibility, plus adequate chemical, mechanical and physical stability. Ion-exchange resins [5][6][7] are employed as the adsorbents in plasma perfusion columns, while polyHEMA-coated active carbon [8][9][10][11] is used for hemoperfusion columns. In Europe, liver support systems, e.g.…”

Section: Introductionmentioning

confidence: 99%

Bilirubin adsorption property of sol–gel-derived titania particles for blood purification therapy

et al. 2008

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“…However, when its conjugation with glucuronic acid is inhibited, as in neonatal jaundice and in hereditary forms of congenital jaundice, excess BR deposits to various tissues, giving rise to severe hyperbilirubinemia and neurotoxicity. Now-a-days, conventional treatments for severe hyperbilirubinemia include phototherapy, 7 haemoperfusion, 8 haemodialysis, 9 and exchange blood transfusion 10 methodology. To date, phototherapy is the most effective treatment for severe jaundice.…”

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confidence: 99%

Research Update: Facile synthesis of CoFe2O4 nano-hollow spheres for efficient bilirubin adsorption

et al. 2015

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Herein, we report an unprecedented bilirubin (BR) adsorption efficiency of CoFe2O4 (CFO) nanostructures in contrast to the commercially available activated carbon and resin which are generally used for haemoperfusion and haemodialysis. We have synthesized CFO nanoparticles of diameter 100 nm and a series of nano-hollow spheres of diameter 100, 160, 250, and 350 nm using a simple template free solvothermal technique through proper variation of reaction time and capping agent, oleylamine (OLA), respectively, and carried out SiO2 coating by employing Stöber method. The comparative BR adsorption study of CFO and SiO2 coated CFO nanostructures indicates that apart from porosity and hollow configuration of nanostructures, the electrostatic affinity between anionic carboxyl group of BR and cationic amine group of OLA plays a significant role in adsorbing BR. Finally, we demonstrate that the BR adsorption capacity of the nanostructures can be tailored by varying the morphology as well as size of the nanostructures. We believe that our developed magnetic nanostructures could be considered as a potential material towards therapeutic applications against hyperbilirubinemia.

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Resin Hemoperfusion for Unconjugated Bilirubin Removal

Cited by 24 publications

References 0 publications

Specific sorbents for bilirubin removal from human plasma: Congo red-modified poly(EGDMA/HEMA) microbeads

Specific sorbents for bilirubin removal from human plasma: Congo red-modified poly(EGDMA/HEMA) microbeads

Bilirubin adsorption property of sol–gel-derived titania particles for blood purification therapy

Research Update: Facile synthesis of CoFe2O4 nano-hollow spheres for efficient bilirubin adsorption

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