Residues of Ceftiofur Sodium in Rabbit Tissues

Abstract

This study was designed to determine ceftiofur sodium residues of different rabbit tissues after intramuscular injection at a dose of 2.2 mg/kg BW. A total of twenty-four healthy male New Zealand White rabbits were divided into two groups; the first group (n = 21) was injected with ceftiofur for five successive days, while the second group (n = 3) untreated (control). Liver, kidney, pectoral and thigh muscles, spleen, heart, blood and lung from each rabbit were collected at the 1st, 3rd, 5th, 7th, 9th, 15th and 21st day post ceftiofur sodium treatment. Tissues were extracted and ceftiofur residues were analyzed using high-performance liquid chromatography (HPLC). Ceftiofur remained within the detectable level till the 5th day in most of the investigated tissues (liver, kidney, lung, heart, pectoral and thigh muscles) and serum, but still detected till the 7th and 9th day post treatment in lung and kidney, respectively. It can be concluded that rabbit muscles and livers could be consumed safely at the 3rd day post treatment with that dose, while, rabbit kidneys could be consumed safely at the 1st day post treatment with that dose without any hazards on consumers because the residual level is below the recommended MRL.

Effect of Dietary Microalgae on Growth Performance, Profiles of Amino and Fatty Acids, Antioxidant Status, and Meat Quality of Broiler Chickens

“…Antibiotics have been widely used in diets of livestock for many years to control disease and improve production performance [2]. However, there is a global trend to reducing their use in poultry feeds to avoid the risk of antibiotic residues in meat and minimize the development of antibiotic resistance [3][4][5][6]. Therefore, the addition of antibiotics as growth promotersin animal diet has been prohibited [7] Hence, searching for potential growth promoting alternatives with no side effects is very essential [8].…”

Carcass yields, muscle amino acid and fatty acid profiles, and antioxidant indices of broilers supplemented with synbiotic and/or organic acids

“…In the past decades, antibiotics were applied as growth promoters to improve the feed utilization and health condition in poultry species (Gollnisch, Wald, & Berk, ). The supplementation of antibiotics to poultry diets had resulted in major troubles such as drug residues in poultry meat and imbalance of microbial population dynamics in the intestine (Sorum & Sunde, ), as well as the hazard of antibiotic resistance (Abdel Aziz, El‐Nabtity, Barawy, & Saleh, ). Therefore, several candidates, such as synbiotics, plant extracts and organic acids (OA), have been utilized to replace the antibiotic additives (Mehdipour, Afsharmanesh, & Sami, ).…”

Evaluation of the Comparative Effect of Irradiated and Controlled Feed on the Body Growth of Broiler Chicken

“…Antibiotics have been widely used in diets of livestock for many years to control disease and improve production performance (Gaskin et al, 2002). However, there is a global trend to reducing their use in poultry feeds to avoid the risk of antibiotic residues in meat and minimize the development of antibiotic resistance (Abdel-Aziz et al, 2017;Founou et al, 2016;Thanner et al, 2016;Venter et al, 2017). Therefore, the addition of antibiotics as growth promoters in animal diet has been prohibited.…”