Residual periosteum tension is insufficient to directly modulate bone growth

Elucidating Multiscale Periosteal Mechanobiology: A Key to Unlocking the Smart Properties and Regenerative Capacity of the Periosteum?

“…Characterization of the the periosteum's material and mechanical properties will allow for a better understanding of the periosteum's role as the barrier membrane, 38,[51][52][53] PDCs are commonly used for bone and cartilage tissue engineering applications due to their ability to differentiate into tissues of mesodermal origin, specifically bone and cartilage. [16][17][18][19][54][55][56] Current methods for isolating PDCs from periosteum include enzymatic digestion or explant culture. 38 The choice of isolation protocol has not only practical, but also potentially important mechano-chemo-biological consequences; digestion liberates cells from the entire periosteum and exposes cells to collagenase (with unknown downstream effects) and explant culture favors the isolation of motile cells, which are capable of egressing from the cambium layer.…”

“…In addition, these biophysical and chemical effects are likely to interact at multiple length scales, that is, tissue-, cell-, and molecular-length scales. While previous studies have addressed specific aspects of the mechanobiological structure and function within the periosteum, for example, cellular changes in the periosteum subjected to mechanical loading, [16][17][18][19] structural changes in developing 20 and in aging periosteum, 21 as well as mechanical properties of periosteum from different species, 22 and anatomic sampling sites, 23 relatively little is known with regard to periosteum's multiscale mechanobiology.…”

European Society of Biomechanics S.M. Perren Award 2010: An adaptation mechanism for fibrous tissue to sustained shortening

“…Mineralized bone tissue could then be extracted with the periosteum held at in vivo length (method is illustrated in Fig. 1, and previously described Foolen et al, 2009). …”

Mechanics of chondrocyte hypertrophy

“…An alternative explanation is that fibrils partly turn over and adjust to the level of strain they experience by increasing the number of serial monomers, theoretically resulting in a longer fibril under unloaded conditions. Such mechanism is likely to keep stresses in growing soft tissues low (Foolen et al 2009). The present simulations are indifferent to the exact mechanism of collagen adaptation.…”