Residual metabolic tumor activity after chemo-radiotherapy is mainly located in initially high FDG uptake areas in rectal cancer

Bogaard, J. van den; Janssen, M.; Janssens, Guillaume; Buijsen, Jeroen; Reniers, Brigitte; Lambin, Philippe; Lammering, Guido; Öllers, Michel

doi:10.1016/j.radonc.2011.04.004

Cited by 28 publications

(29 citation statements)

References 29 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, a subvolume defined on baseline PET with the 60 % of SUV max threshold appears to be an acceptable choice for dose escalation since it avoids missing the nidus of recurrence (as shown by the A x ∩R 9 0/R 90 index and OF) and it limits the irradiation of areas with a low risk of relapse (as shown by the A x ∩R 40 / A x index). Similar results (threshold=50 % of SUV max ) have been reported in lung cancer and rectal cancers [19][20][21].…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

High FDG uptake areas on pre-radiotherapy PET/CT identify preferential sites of local relapse after chemoradiotherapy for locally advanced oesophageal cancer

Calais

Dubray

Nkhali

et al. 2015

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 87%

“…It is also superior to CT to identify tumour extension in the oesophagus, facilitating the delineation of RT target volumes [17,18]. High FDG uptake (hotspot) on pre-RT FDG PET/CT has been reported to identify intra-tumour sites at increased risk of relapse after RT in non-small cell lung cancer (NSCLC) and in rectal cancer [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

High FDG uptake areas on pre-radiotherapy PET/CT identify preferential sites of local relapse after chemoradiotherapy for locally advanced oesophageal cancer

Calais

Dubray

Nkhali

et al. 2015

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

show abstract

“…Consensus guidelines reports try to help clinicians but still large areas of controversies exist [23][24][25].…”

Section: Practice Pointsmentioning

confidence: 99%

VATE: VAlidation of high TEchnology based on large database analysis by learning machine

Meldolesi

Soest²,

Alitto

et al. 2014

Colorect. Cancer

View full text Add to dashboard Cite

SummaryThe interaction between implementation of new technologies and different outcomes can allow a broad range of researches to be expanded. The purpose of this paper is to introduce the VAlidation of high TEchnology based on large database analysis by learning machine (VATE) project that aims to combine new technologies with outcomes related to rectal cancer in terms of tumor control and normal tissue sparing. Using automated computer bots and the knowledge for screening data it is possible to identify the factors that can mostly influence those outcomes. Population-based observational studies resulting from the linkage of different datasets will be conducted in order to develop predictive models that allow physicians to share decision with patients into a wider concept of tailored treatment. KeywordSOver the past decade, remarkable advances in cancer care with the adoption of newest diagnostic and treatment technologies has created new challenges [1].The use and role of medical imaging technologies in clinical oncology has greatly expanded from a primarily diagnostic tool to award a central role in the context of individualized medicine. Multiple imaging features involving descriptors of intensity distribution, spatial relationships between the various intensity levels, texture heterogeneity patterns, descriptors of shape and the relations of the tumor with the surrounding tissues have been analyzed for their relationship with treatment outcomes or Practice points• Progress in individualized medicine has created new challenges.• New technology implementation.• Necessity to develop systems that allow shared decision making by the physicians and the patients and chose a tailored treatment.• Standardization of the data collection -ontology.• Sharing data: Semantic Web and Resource Description Framework.• Statistical analysis.• Privacy protection of individual patients.• Development of predictive models based on individual patients features which complement existing consensus or guidelines.For reprint orders, please contact: reprints@futuremedicine.com

show abstract

“…Dabei ist die Methode jedoch kostenintensiver als CT oder MRT. Die Response-Evaluation und die präzise Zielvolumendefinition für die Strahlentherapie sind interessante Einsatzfelder für die PET/CT [3,11,34].…”

Section: Rolle Der Pet/ctunclassified

Bedeutung der Schnittbildverfahren für das Staging des Rektumkarzinoms

Schäfer

Langer

Baumann

2012

Chirurg

View full text Add to dashboard Cite

The ongoing diversification of treatment strategies for rectal cancer justifies the demand for highly specialized radiological imaging. Currently, numerous studies have underlined the ability of magnetic resonance imaging (MRI) to determine those parameters that are critical for therapeutic decision-making and prognosis in rectal cancer. Computed tomography (CT) does not meet the criteria of a first line diagnostic procedure with regard to local staging but will remain the workhorse in the search for distant metastases. The increasing acceptance of extended MRI-based concepts will, however, improve cost-effectiveness and simplify patient management. Response evaluation and detection of recurrent disease are the major indications for positron emission tomography (PET)/CT, which is currently not routinely recommended.

show abstract

Residual metabolic tumor activity after chemo-radiotherapy is mainly located in initially high FDG uptake areas in rectal cancer

Abstract: This study presents areas in rectal tumors with an initially high FDG uptake to be most likely to show residual disease after CRT. This could indicate a higher (C)RT-resistance for tumor regions with a high FDG uptake prior to treatment.

Cited by 28 publications

References 29 publications

High FDG uptake areas on pre-radiotherapy PET/CT identify preferential sites of local relapse after chemoradiotherapy for locally advanced oesophageal cancer

High FDG uptake areas on pre-radiotherapy PET/CT identify preferential sites of local relapse after chemoradiotherapy for locally advanced oesophageal cancer

VATE: VAlidation of high TEchnology based on large database analysis by learning machine

Bedeutung der Schnittbildverfahren für das Staging des Rektumkarzinoms

Contact Info

Product

Resources

About