Residence characteristics and risk of nasopharyngeal carcinoma in southern China: A population-based case-control study

Chen, Yufeng; Chang, Ellen T.; Liu, Zhiwei; Liu, Qing; Cai, Yonglin; Zhe, Zhang; Chen, Guomin; Huang, Qihong; Xie, Shiwei; Cao, Su‐Mei; Jia, Wei‐Hua; Zheng, Yuming; Li, Yancheng; Lin, Longde; Ernberg, Ingemar; Zhao, Hongwei; Feng, Ruimei; Huang, Guangwu; Zeng, Yi; Zeng, Yi‐Xin; Adami, Hans‐Olov; Ye, Weimin

doi:10.1016/j.envint.2021.106455

Cited by 15 publications

(13 citation statements)

References 23 publications

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“…We also found that occupational exposure to smoke or exhaust from diesel, firewood, asphalt/tar, vehicle, and welding was associated with an elevated risk of NPC, with positive duration-response trends. These consistent results, along with previous evidence demonstrating positive associations between household exposure to indoor air pollutants and the risk of NPC, 52,53,54 support a causal role of inhaled combustion products in NPC development.…”

Section: Discussionsupporting

confidence: 86%

Occupational exposures and risk of nasopharyngeal carcinoma in a high‐risk area: A population‐based case‐control study

Chen

Chang

Liu

et al. 2021

Cancer

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BACKGROUND:The potential role of occupational exposures in the development of nasopharyngeal carcinoma (NPC) remains unclear, particularly in high-incidence areas. METHODS: The authors conducted a population-based case-control study, consisting of 2514 incident NPC cases and 2586 randomly selected population controls, in southern China from 2010 to 2014. Occupational history and other covariates were self-reported using a questionnaire. Multivariate logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for the risk of NPC associated with occupational exposures. Restricted cubic splines were used to evaluate potentially nonlinear duration-response relations. RESULTS: Individuals who had exposure to occupational dusts (

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Section: Discussionsupporting

confidence: 86%

Occupational exposures and risk of nasopharyngeal carcinoma in a high‐risk area: A population‐based case‐control study

Chen

Chang

Liu

et al. 2021

Cancer

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“…Nasopharyngeal carcinoma (NPC) occurs with a high incidence rate in East and Southeast Asia, especially in southern China, including Guangdong, Guangxi, and Hong Kong [1][2][3]. Some NPC patients are difficult to diagnose in early clinical stages, because they show no obvious symptoms.…”

Section: Introductionmentioning

confidence: 99%

Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase

et al. 2021

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Our previous studies have elucidated a possible connection between long intergenic non-protein coding RNA 2570 (LINC02570) and nasopharyngeal carcinoma (NPC). However, the precise mechanism by which LINC02570 promotes NPC remains unknown. We used quantitative polymerase chain reaction (qPCR) to detect LINC02570 expression in nasopharyngeal cell lines, NPC tissues, and chronic rhinitis tissues. Subcellular LINC02570 localization was confirmed by fluorescence in situ hybridization (FISH). The effects of LINC02570 stable knockdown and overexpression on viabillity, proliferation, migration, and invasion were analyzed using 3-(4,5-Dimethyl-2-Thiazolyl)-2,5-Diphenyl-2-H-Tetrazolium bromide (MTT), a colorimetric focus-formation assay, a wound healing assay, and transwell assays. RNA crosstalk analysis in silico predicted microRNA-4649-3p (miR-4649-3p) binding to LINC02570 or sterol regulatory element binding transcription factor 1 (SREBF1). A dual luciferase reporter assay was used to confirm potential interactions. Sterol regulatory element binding protein 1 (SREBP1) and fatty acid synthase (FASN) expression were detected by western blotting. The results suggest that LINC02570 is upregulated in late clinical stage NPC patients, and promotes NPC progression by adsorbing miR-4649-3p to up-regulate SREBP1 and FASN. This study elucidates a potential chemotherapeutic target involved in lipid metabolism in NPC.

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“…Other environmental factors, such as household indoor air pollution, early-life salted-fish consumption, and residential and occupational exposures, have also been linked to the development of NPC [ 3 , 31–33 ]. Our population-based study plus prior hospital-based studies [ 11 , 18 ], however, found no relationship between a broad range of environmental factors and EBV reactivation.…”

Section: Discussionmentioning

confidence: 99%

Environmental Factors for Epstein-Barr Virus Reactivation in a High-Risk Area of Nasopharyngeal Carcinoma: A Population-Based Study

Chen

Chang

Liu

et al. 2022

Open Forum Infectious Diseases

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Background Epstein-Barr virus (EBV) reactivation from latent to lytic infection has been considered as a key step in nasopharyngeal carcinoma oncogenesis. However, epidemiological evidence regarding environmental risk factors for EBV reactivation on a population level remains largely lacking. Methods We enrolled 1,916 randomly selected adults from the general population of Guangdong and Guangxi, China, from 2010 to 2014. Information on environmental factors was collected via a structured interview. Serum IgA antibodies against EBV viral capsid antigen and nuclear antigen 1 were measured by ELISA to evaluate EBV reactivation status. We used logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs) for the associations of EBV reactivation with various environmental factors. Results No associations were observed between EBV reactivation and extensive environmental factors, including alcohol or tea drinking, a history of chronic ear/nose/throat diseases, use of medications or herbs, consumption of salted fish or preserved foods, oral hygiene, sibship structure, and various residential and occupational exposures. Only cigarette smoking was associated with EBV reactivation (current smokers vs. never smokers, OR = 1.37, 95% CI = 1.02-1.83), with positive exposure-response trends with increasing intensity, duration, and pack-years of smoking. Conclusions Consistent with previous studies, we found an association between cigarette smoking and EBV reactivation. Other examined exposures were not associated with EBV reactivation. These null results could suggest either more complex interactions between exposures and EBV reactivation or a predominant role of host and/or viral genetic variation.

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Residence characteristics and risk of nasopharyngeal carcinoma in southern China: A population-based case-control study

Cited by 15 publications

References 23 publications

Occupational exposures and risk of nasopharyngeal carcinoma in a high‐risk area: A population‐based case‐control study

Occupational exposures and risk of nasopharyngeal carcinoma in a high‐risk area: A population‐based case‐control study

Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase

Environmental Factors for Epstein-Barr Virus Reactivation in a High-Risk Area of Nasopharyngeal Carcinoma: A Population-Based Study

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